Authors
Petrovic A, Do TT, Fernández-Busnadiego R
Journal
Current Opinion in Neurobiology
Citation
Curr Opin Neurobiol. 2024 Dec 11;90:102939.
Abstract
Cryo-electron tomography (cryo-ET) visualizes natively preserved cellular ultrastructure at molecular resolution. Recent developments in sample preparation workflows and image processing tools enable growing applications of cryo-ET in cellular neurobiology. As such, cryo-ET is beginning to unravel the in situ macromolecular organization of neurons using samples of increasing complexity. Here, we highlight advances in cryo-ET technology and review its recent use to study neuronal architecture and its alterations under disease conditions.
