Moser, Tobias

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17.11.2025

CochleaNet: deep learning-based image analysis for cochlear connectomics and gene therapy

Authors Roos L, Meric Diniz A, Koert E, Schilling M, Uhl M, Thirumalai A, Aakhte M, Kusch K, Huisken J, Moser T, Pape C Journal BioRxiv Citation bioRxiv 2025.11.16.688700. Abstract With the emergence of gene and optogenetic therapies targeting deafness, the comprehensive analysis of the molecular anatomy and physiology of
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13.11.2025

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue

Authors Aakhte M, Müller GF, Roos L, Li J, Göpel T, Weiss KR, Diniz AM, Wenzel J, Schwaninger M, Moser T, Huisken J Journal Nature Biotechnology Citation Nat Biotechnol. 2025 Nov 13. Abstract Light-sheet microscopy is ideal for imaging large and cleared tissues, but achieving a high isotropic resolution for
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05.11.2025

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

Authors Kapoor R, Kim H, Garlick E, Lima MADRBF, Esch K, Ruhwedel T, Möbius W, Wolf F, Moser T Journal Science Advances Citation Sci. Adv.11,eady4344(2025). Abstract The cochlea encodes sounds into neural signals at the synapses of inner hair cells (IHCs) and spiral ganglion neurons (SGNs) with remarkable fidelity. To
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23.10.2025

International expert consensus on gene therapy for hereditary hearing loss: based on clinical trials

Authors Fan X, Gao Z, Zhong J, Chen Y, Chen X, Landegger LD, Moser T, Zeng FG, Sun Y, Jin X, Nash R, Chien WW, Jiang D, Greinwald JH, Bance M, Rodríguez MM, Lee SY, Feng G, Yang H, Wu CC, Xu L, Yuan W, Feng Y, Zhao Y, Vona
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20.10.2025

Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity

Authors Karagulyan N, Überegger M, Qi Y, Babai N, Hofer F, Johnson Chacko L, Wang F, Luque M, Glueckert R, Schrott-Fischer A, Hua Y, Moser T, Bandtlow C Journal eLife Citation Elife. 2025 Oct 20;14:RP103481 Abstract Sound encoding depends on the precise and reliable neurotransmission at the afferent synapses between
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17.10.2025

Structure and function of otoferlin, a synaptic protein of sensory hair cells essential for hearing

Authors Chen H, Cretu C, Trebilcock A, Evdokimova N, Babai N, Feldmann L, Leidner F, Benseler F, Mutschall S, Esch K, Szabo CZK, Pena V, Pape C, Grubmüller H, Strenzke N, Brose N, Wichmann C, Preobraschenski J, Moser T Journal Sciende Advances Citation Sci Adv. 2025 Oct 17;11(42):eady8532. Abstract Hearing
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08.09.2025

Is CABP2-Associated Hearing Loss (DFNB93) a Gene Therapy Target? Preclinical Progress and Patient Registry

Authors Vona B, Wollnik B, Strenzke N, Pangrsic T, Moser T Journal MedComm Citation MedComm 6, no. 9 (2025): 6, e70363. Abstract CABP2 modulates presynaptic CaV1.3 Ca2+ channel function in inner hair cells (IHCs) and is required for indefatigable synaptic sound encoding. Biallelic variants in CABP2 are associated with non-syndromic
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28.08.2025

SynapseNet: Deep Learning for Automatic Synapse Reconstruction

Authors Muth S, Moschref F, Freckmann L, Mutschall S, Hojas-Garcia-Plaza I, Bahr JN, Petrovic A, Do TT, Schwarze V, Archit A, Weyand K, Michanski S, Maus L, Imig C, Hintze A, Brose N, Wichmann C, Fernandez-Busnadiego R, Moser T, Rizzoli SO, Cooper BH, Pape C Journal Molecular Biology of the
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01.08.2025

Hearing restoration by a low-weight power-efficient multichannel optogenetic cochlear implant system

Authors Jablonski L, Harczos T, Wolf B, Hoch G, Khurana L, Dieter A, Roos L, Hessler R, Ayub S, Ruther P, Moser T Journal Journal of Neural Engineering Citation J Neural Eng. 2025 Aug 1;22(4). Abstract Objective. In case of deafness, electrical cochlear implants (eCIs) bypass dysfunctional or lost hair
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28.07.2025

Efficient and sustained optogenetic control of sensory and cardiac systems

Authors Alekseev A, Hunniford V, Zerche M, Jeschke M, El May F, Vavakou A, Siegenthaler D, Hüser MA, Kiehn SM, Garrido-Charles A, Meyer A, Rambousky A, Alvanos T, Witzke I, Rojas-Garcia KD, Draband MD, Cyganek L, Klein E, Ruther P, Huet A, Trenholm S, Macé E, Kusch K, Bruegmann T,
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