Moser, Tobias

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18.06.2025

Gating of hair cell Ca2+ channels governs the activity of cochlear neurons

Authors Karagulyan N, Thirumalai A, Michanski S, Qi Y, Fang Q, Wang H, Ortner NJ, Striessnig J, Strenzke N, Wichmann C, Hua Y, Moser T Journal Science Advances Citation Sci Adv. 2025 Jun 20;11(25):eadu7898. Abstract Our sense of hearing processes sound intensities spanning six orders of magnitude. In the ear,
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28.05.2025

Structural insights into lipid membrane binding by human ferlins

Authors Cretu C, Chernev A, Szabo CZK, Pena V, Urlaub H, Moser T, Preobraschenski J Journal EMBO Journal Citation EMBO J. 2025 May 28. Abstract Ferlins are ancient membrane proteins with a unique architecture, and play central roles in crucial processes that involve Ca2+-dependent vesicle fusion. Despite their links to
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27.05.2025

Toward elucidating the mechanism of cochlear stimulation by infrared light

Authors Moser T, Roos L Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2025 Jun 3;122(22):e2507582122. Abstract No abstract available. DOI 10.1073/pnas.2507582122   Pubmed Link
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20.05.2025

3D imaging of the human temporal bone by X-ray phase-contrast tomography

Authors Schaeper JJ, Tafforeau P, Kampshoff CA, Thomas C, Meyer A, Stadelmann C, Liberman MC, Moser T, Salditt T Journal npj Imaging Citation npj Imaging 3, 21 (2025). Abstract Studying the subtle and intricate three-dimensional structure of the human cochlea embedded in the temporal bone requires structure-preserving imaging approaches with
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15.05.2025

Combinatorial transcriptional regulation establishes subtype-appropriate synaptic properties in auditory neurons

Authors Bastille I, Lee L, Moncada-Reid C, Yu WM, Sitko A, Yung A, Zamani M, Christophersen N, Maroofian R, Galehdari H, Babai N, Vona B, Moser T, Goodrich L Journal Cell Reports Citation Cell Rep 2025. accepted manuscript. Abstract Neurons develop diverse synapses that vary in content, morphology, and size.
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13.05.2025

CryoRhodopsins: a comprehensive characterization of a new clade of microbial rhodopsins from cold environments

Authors Lamm GHU, Marin E, Schellbach AV, Stetsenko A, Alekseev A, Bourenkov G, Borshchevskiy V, Asido M, Agthe M, Engilberge S, Rose SL, Caramello N, Royant A, Schneider TR, Bateman A, Mager T, Moser T, Wachtveitl J, Guskov A, Kovalev K Journal Science Advances Citation Sci Adv. 2025 accepted manuscript.
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28.04.2025

Investigation of neuromodulation of the endbulb of Held synapse in the cochlear nucleus by serotonin and norepinephrine

Authors Groshkova MB, Alvanos T, Qi Y, Wang F, Wichmann C, Hua Y, Moser T Journal Frontiers in Cellular Neuroscience Citation Front. Cell. Neurosci., 28 April 2025 Abstract Introduction: Synapses vary greatly in synaptic strength and plasticity, even within the same circuitry or set of pre- and postsynaptic neurons. Neuromodulation
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25.04.2025

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

Authors Kapoor R, Kim H, Garlick E, Lima MARBF, Ruhwedel T, Moebius W, Wolf F, Moser T Journal BioRxiv Citation bioRxiv 2025.04.22.649963. Abstract For us to hear, the cochlea encodes sounds into neural signals at synapses of inner hair cells (IHCs) and the auditory nerve with remarkable fidelity. To achieve
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18.03.2025

Improved optogenetic modification of the spiral ganglion neurons for future optical cochlear implants

Authors Thirumalai A, Henseler J, Enayati M, Kusch K, Hessler R, Moser T, Huet AT Journal Theranostics Citation Theranostics 2025; 15(10):4270-4286. Abstract Optogenetic stimulation has become a promising approach for restoring lost body function. For example, partial restoration of vision has been achieved in a blind patient and preclinical proof-of-concept
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07.03.2025

3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography

Authors Schaeper JJ, Kampshoff CA, Wolf BJ, Roos L, Michanski S, Ruhwedel T, Eckermann M, Meyer A, Jeschke M, Wichmann C, Moser T, Salditt T Journal Scientific Reports Citation Sci Rep. 2025 Mar 7;15(1):7933. Abstract Multi-scale X-ray phase contrast tomography (XPCT) enables three-dimensional (3D), non-destructive imaging of intact small animal
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