Moser, Tobias

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17.01.2024

CryoRhodopsins: a comprehensive characterization of a new clade of microbial rhodopsins from cold environments

Authors Lamm GHU, Marin E, Schellbach AV, Stetsenko A, Alekseev A, Bourenkov G, Borshchevskiy V, Asido M, Agthe M, Engilberge S, Rose SL, Caramello N, Royant A, Schneider TR, Bateman A, Mager T, Moser T, Wachtveitl J, Guskov A, Kovalev K Journal BioRxiv Citation bioRxiv 2024.01.15.575777. Abstract Microbial rhodopsins are
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19.12.2023

Proteomic analysis reveals the composition of glutamatergic organelles of auditory inner hair cell

Authors Cepeda AP, Ninov M, Neef J, Parfentev I, Kusch K, Reisinger E, Jahn R, Moser T, Urlaub H Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2023 Dec 19:100704. Abstract In the ear, inner hair cells (IHCs) employ sophisticated glutamatergic ribbon synapses with afferent neurons to transmit auditory
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12.12.2023

Probing the role of the C2F domain of otoferlin

Authors Chen H, Fang Q, Benseler F, Brose N, Moser T Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2023 Dec 12;16:1299509. Abstract Afferent synapses of cochlear inner hair cells (IHCs) employ a unique molecular machinery. Otoferlin is a key player in this machinery, and its genetic defects cause
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08.12.2023

Ca2+-binding to the C2E domain of otoferlin is required for hair cell exocytosis and hearing

Authors Chen H, Monga M, Fang Q, Slitin L, Neef J, Chepurwar SS, Mingroni Netto RC, Lezirovitz K, Tabith A Jr, Benseler F, Brose N, Kusch K, Wichmann C, Strenzke N, Vona B, Preobraschenski J, Moser T Journal Protein & Cell Citation Protein & Cell. 2023 Dec 8:pwad058. accepted manuscript.
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29.11.2023

Ca2+ regulation of glutamate release from inner hair cells of hearing mice

Authors Jaime Tobón LM, Moser T Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2023 Dec 5;120(49):e2311539120. Abstract In our hearing organ, sound is encoded at ribbon synapses formed by inner hair cells (IHCs) and spiral
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18.11.2023

Efficient and sustained optogenetic control of nervous and cardiac systems

Authors Zerche M, Hunniford V, Alekseev A, El May F, Vavakou A, Siegenthaler D, Hueser MA, Kiehn SM, Garrido-Charles A, Alvanos T, Witzke I, Trenholm S, Macé E, Kusch K, Bruegmann T, Wolf BJ, Mager T, Moser T Journal BioRxiv Citation bioRxiv 2023.11.17.567544. Abstract Optogenetic control of cells is a
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06.10.2023

Diversity matters – extending sound intensity coding by inner hair cells via heterogeneous synapses

Authors Moser T, Karagulyan N, Neef J, Jaime Tobon LM Journal EMBO Journal Citation EMBO J. 2023.e114587. Abstract Our sense of hearing enables the processing of stimuli that differ in sound pressure by more than six orders of magnitude. How to process a wide range of stimulus intensities with temporal
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22.09.2023

Devising a framework of optogenetic coding in the auditory pathway: insights from auditory midbrain recordings

Authors Micheal M, Wolf BJ, Klinge-Strahl A, Jeschke M, Moser T, Dieter A Journal Brain Stimulation Citation Brain Stimul. 2023 Sep 29:S1935-861X(23)01920-4. Abstract Cochlear implants (CIs) restore activity in the deafened auditory system via electrical stimulation of the auditory nerve. As the spread of electric current in biological tissues is
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06.09.2023

Synaptic activity is not required for establishing heterogeneity of inner hair cell ribbon synapses

Authors Karagulyan N, Moser T Journal Frontiers in Molecular Neuroscience – Molecular Signalling and Pathways Citation Front Mol Neurosci. 2023 Sep 6;16:1248941. Abstract Neural sound encoding in the mammalian cochlea faces the challenge of representing audible sound pressures that vary over six orders of magnitude. The cochlea meets this demand
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25.08.2023

En route to sound coding strategy for optical cochlear implants

Authors Khurana L, Harczos T, Moser T, Jablonski L Journal iScience Citation iScience (2023). Abstract In 2019, disabling hearing loss affected 430 million people worldwide and will reach over 700 million by 2050. Severe-to-complete sensorineural hearing loss is often treated by electrical cochlear implants (eCIs) bypassing dysfunctional or lost hair
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