Moser, Tobias

Authors Krinner S, Predoehl F, Burfeind D, Vogl C, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 14:651935. Abstract The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time. Here, we

Authors Keppeler D, Kampshoff C, Thirumalai A, Duque-Afonso CJ, Schaeper J, Quilitz T, Töpperwien M, Vogl C, Hessler R, Meyer A, Salditt T, Moser T Journal PNAS Citation PNAS May 4, 2021 118 (18) e2014472118. Abstract The cochlea of our auditory system is an intricate structure deeply embedded in the

Authors Huet AT, Dombrowsik T, Rankovic V, Thirumalai A, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 14:635897. Abstract Optogenetic stimulation of type I spiral ganglion neurons (SGNs) promises an alternative to the electrical stimulation by current cochlear implants (CIs) for improved hearing restoration by future optical

Authors Wrobel C, Zafeiriou MP, Moser T Journal EBioMedicine Citation EBioMedicine. 2021 Jan 7;63:103171. Abstract Sensorineural hearing impairment is the most frequent form of hearing impairment affecting 1–2 in 1000 newborns and another 1 in 1000 adolescents. More than 50% of congenital hearing impairment is of genetic origin and some

Authors Rankovic V, Vogl C, Dörje N M, Bahader I, Duque-Afonso C J, Thirumalai A, Weber T, Kusch K, Strenzke N, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 13:600051. Abstract Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf

Authors Hua Y, Ding X, Wang H, Wang F, Lu Y, Neef J, Gao Y, Moser T, Wu H Journal Cell Reports Citation Cell Rep. 2021 Jan 5;34(1):108551. Abstract Recent studies reveal great diversity in the structure, function, and efferent innervation of afferent synaptic connections between the cochlear inner hair

Authors Özcete Ö, Moser T Journal EMBO Journal Citation EMBO J (2020)e106010. Abstract The cochlea encodes sound pressures varying over six orders of magnitude by collective operation of functionally diverse spiral ganglion neurons (SGNs). The mechanisms enabling this functional diversity remain elusive. Here, we asked whether the sound intensity information,

Authors Kleinlogel S, Vogl C, Jeschke M, Neef J, Moser T Journal Physiological Reviews Citation Physiol Rev. 2020 Oct 1;100(4):1467-1525. Abstract Impairments of vision and hearing are highly prevalent conditions limiting the quality of life and presenting a major socioeconomic burden. For a long time, retinal and cochlear disorders have

Authors Keppeler D, Schwaerzle M, Harczos T, Jablonski L, Dieter A, Wolf B, Ayub S, Vogl C, Wrobel C, Hoch G, Abdellatif K, Jeschke M, Rankovic V, Paul O, Ruther P, Moser T Journal Science Translational Medicine Citation Sci. Transl. Med. 12, eabb8086 (2020). Abstract Cochlear implants provide the brain

Authors Dieter A, Klein E, Keppeler D, Jablonski L, Harczos T, Hoch G, Rankovic V, Paul O, Jeschke M, Ruther P, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2020 Jun 29;e12387. Abstract Electrical cochlear implants (eCIs) partially restore hearing and enable speech comprehension to more than half