Moser, Tobias

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19.05.2026

Optogenetic cochlear stimulation evokes midbrain activity with near-physiological temporal fidelity

Authors Koert E, Götz J, Albrecht N, Vavakou A, Wolf BJ, Moser T Journal BioRxiv Citation bioRxiv 2026.05.16.724905 Abstract When hearing fails, stimulation of the auditory nerve by electrical cochlear implants (eCIs) partially restores hearing, with most eCI users achieving open speech understanding. However, the broad current spread from each
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19.05.2026

Multichannel optical cochlear implants enable spectrally distinct auditory activity

Authors Albrecht N, Koert E, Vavakou A, Roos L, Jablonski L, Marcoleta JP, Cardona Audi J, Alfken J, Aakhte M, Klein E, Salditt T, Huisken J, Ruther P, Mager T, Kusch K, Moser T Journal BioRxiv Citation bioRxiv 2026.05.15.725096 Abstract When hearing fails, cochlear implants (CIs) partially restore auditory perception.
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28.03.2026

Generation of marmoset monkeys with a non-mosaic disruption of the OTOF gene as a model of human deafness

Authors Kahland T, Lindenwald DL, Jeschke M, Kusch K, Tkachenko Eikel O, Uhl M, Rüger N, Drummer C, Wolf B, Benseler F, Brose N, Behr R, Moser T Journal Nature Communications Citation Nat Commun 17, 3033 (2026). Abstract Disabling hearing impairment is a common human sensory deficit. OTOF is a
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26.03.2026

Dysferlin stabilizes membrane nanodomains of cardiomyocytes after myocardial infarction

Authors Wegener JB, Zühlke Y, Fleischhacker C, Marks J, Foo B, Bader N, Riedemann GC, Wedemeyer J, Vu KC, Vergel Leon AM, Paulke NJ, Kohl T, Urlaub H, Schmidt C, Hasenfuß G, Moser T, Rog-Zielinska EA, Lenz C, Lehnart SE, Brandenburg S Journal Scientific Reports Citation Sci Rep. 2026 Mar
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13.01.2026

Establishing synthetic ribbon-type active zones in a heterologous expression system

Authors Kapoor R, Do TT, Schwenzer N, Petrovic A, Dresbach T, Lehnart SE, Fernández-Busnadiego R, Moser T Journal eLife Citation Elife. 2026 Jan 13;13:RP98254. Abstract Encoding of several sensory modalities into neural signals is mediated by ribbon synapses. The synaptic ribbon tethers synaptic vesicles at the presynaptic active zone (AZ)
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09.12.2025

Channelrhodopsin variants for high-rate optogenetic neurostimulation at low light intensities

Authors Roos L, Garrido-Charles A, Albrecht N, Vavakou A, Alekseev A, Bleyer M, Thirumalai A, Mittring A, Alvanos T, Huet AT, Bamberg E, Kusch K, Wolf BJ, Moser T, Mager T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2025 Dec 9. Abstract Optogenetics allows versatile control of excitable cell
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17.11.2025

CochleaNet: deep learning-based image analysis for cochlear connectomics and gene therapy

Authors Roos L, Meric Diniz A, Koert E, Schilling M, Uhl M, Thirumalai A, Aakhte M, Kusch K, Huisken J, Moser T, Pape C Journal BioRxiv Citation bioRxiv 2025.11.16.688700. Abstract With the emergence of gene and optogenetic therapies targeting deafness, the comprehensive analysis of the molecular anatomy and physiology of
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13.11.2025

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue

Authors Aakhte M, Müller GF, Roos L, Li J, Göpel T, Weiss KR, Diniz AM, Wenzel J, Schwaninger M, Moser T, Huisken J Journal Nature Biotechnology Citation Nat Biotechnol. 2025 Nov 13. Abstract Light-sheet microscopy is ideal for imaging large and cleared tissues, but achieving a high isotropic resolution for
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05.11.2025

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

Authors Kapoor R, Kim H, Garlick E, Lima MADRBF, Esch K, Ruhwedel T, Möbius W, Wolf F, Moser T Journal Science Advances Citation Sci. Adv.11,eady4344(2025). Abstract The cochlea encodes sounds into neural signals at the synapses of inner hair cells (IHCs) and spiral ganglion neurons (SGNs) with remarkable fidelity. To
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23.10.2025

International expert consensus on gene therapy for hereditary hearing loss: based on clinical trials

Authors Fan X, Gao Z, Zhong J, Chen Y, Chen X, Landegger LD, Moser T, Zeng FG, Sun Y, Jin X, Nash R, Chien WW, Jiang D, Greinwald JH, Bance M, Rodríguez MM, Lee SY, Feng G, Yang H, Wu CC, Xu L, Yuan W, Feng Y, Zhao Y, Vona
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