Research Alliance

Authors Kleiber N, Lemus-Diaz N, Siller C, Heinrichs M, Mai MMQ, Hackert P, Richter-Dennerlein R, Höbartner C, Bohnsack KE, Bohnsack MT Journal Nature Communications Citation Nat Commun 13, 209 (2022). Abstract Modified nucleotides in tRNAs are important determinants of folding, structure and function. Here we identify METTL8 as a mitochondrial

Authors Oleksiievets N, Sargsyan Y, Thiele JC, Mougios N, Sograte-Idrissi S, Nevskyi O, Gregor I, Opazo F, Thoms S, Enderlein J, Tsukanov R Journal Communications Biology Citation Commun Biol 5, 38 (2022). Abstract DNA point accumulation for imaging in nanoscale topography (DNA-PAINT) is a powerful super-resolution technique highly suitable for

Authors Lehnart SE, Wehrens XHT Journal Physiological Reviews Citation Physiol Rev. 2022 Jan 10. Abstract Junctophilins (JPHs) comprise a family of structural proteins that connect the plasma membrane to intracellular organelles such as the endo/sarcoplasmic reticulum. Tethering of these membrane structures results in the formation of highly organized subcellular junctions

Authors Pavez-Giani MG, Cyganek L Journal Frontiers in Cell and Developmental Biology Citation Front Cell Dev Biol. 2022 Jan 10;9:800529. Abstract   Around one third of patients with mitochondrial disorders develop a kind of cardiomyopathy. In these cases, severity is quite variable ranging from asymptomatic status to severe manifestations including

Authors Hatton C, Ghanem SS, Koss DJ, Abdi IY, Gibbons E, Guerreiro R, Bras J, International DLB Genetics Consortium, Walker L, Gelpi E, Heywood W, Outeiro TF, Attems J, McFarland R, Forsyth R, El-Agnaf OM, Erskine D Journal Brain Citation Brain. 2022 May 24;145(4):1257-1263. Abstract Krabbe disease is an infantile

Authors Vasili E, Dominguez-Meijide A, Flores-León M, Al-Azzani M, Kanellidi A, Melki R, Stefanis L, Outeiro TF Journal Molecular Neurobiology Citation Mol Neurobiol. 2022 Jan 4. Abstract Parkinson’s disease is a progressive neurodegenerative disorder characterized by the accumulation of misfolded alpha-synuclein in intraneuronal inclusions known as Lewy bodies and Lewy

Authors Dietz J, Oelkers M, Hubrich R, Pérez-Lara A, Jahn R, Steinem C, Janshoff A Journal Nano Letters Citation Nano Lett. 2022, Jan 4 Abstract A mechanism for full-length synaptotagmin-1 (syt-1) to interact with anionic bilayers and to promote fusion in the presence of SNAREs is proposed. Colloidal probe force

Authors Michurina A, Sakib S, Kerimoglu C, Krüger DM, Kaurani L, Islam R, Joshi PD, Schröder S, Centeno TP, Zhou J, Pradhan R, Cha J, Xu X, Eichele G, Zeisberg EM, Kranz A, Stewart FA, Fischer A Journal EMBO Journal Citation EMBO J. 2022 Jan 4; 41(1): e106459. Abstract In

Authors Dennerlein S, Poerschke S, Oeljeklaus S, Wang C, Richter-Dennerlein R, Sattmann J, Bauermeister D, Hanitsch E, Stoldt S, Langer T, Jakobs S, Warscheid B, Rehling P Journal Elife Citation Elife. 2021 Dec 31;10:e68213. Abstract Human mitochondria express a genome that encodes thirteen core subunits of the oxidative phosphorylation system

Authors Riera-Tur I, Schäfer T, Hornburg D, Mishra A, da Silva Padilha M, Fernández-Mosquera L, Feigenbutz D, Auer P, Mann M, Baumeister W, Klein R, Meissner F, Raimundo N, Fernández-Busnadiego R, Dudanova I Journal Life Science Alliance Citation Life Sci Alliance. 2021 Dec 21;5(3):e202101185. Abstract The autophagy-lysosomal pathway is impaired