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04.04.2022

The small aromatic compound SynuClean-D inhibits the aggregation and seeded polymerization of multiple α-synuclein strains

Authors Peña-Díaz S, Pujols J, Vasili E, Pinheiro F, Santos J, Manglano-Artuñedo Z, Outeiro TF, Ventura S Journal Journal of Biological Chemistry Citation J Biol Chem. 2022 Apr 4;298(5):101902. Abstract Parkinson’s disease is a neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra, as well as
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01.04.2022

Optimal transfer functions for bandwidth-limited imaging

Authors Stallinga S, Radmacher N, Delon A, Enderlein J Journal Physical Review Research Citation Phys. Rev. Research 4, 023003. Abstract One of the fundamental limits of classical optical microscopy is the diffraction limit of optical resolution. It results from the finite bandwidth of the optical transfer function (or OTF) of
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01.04.2022

Selective optogenetic control of Gq signaling using human Neuropsin

Authors Wagdi A, Malan D, Sathyanarayanan U, Beauchamp JS, Vogt M, Zipf D, Beiert T, Mansuroglu B, Dusend V, Meininghaus M, Schneider L, Kalthof B, Wiegert JS, König GM, Kostenis E, Patejdl R, Sasse P, Bruegmann T Journal Nature Communications Citation Nat Commun. 2022 Apr 1;13(1):1765. Author Correction: Nat Commun.
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31.03.2022

Extracellular Matrix Recycling as a Novel Plasticity Mechanism With a Potential Role in Disease

Authors Dankovich TM, Rizzoli SO Journal Frontiers in Cellular Neuroscience Citation Front Cell Neurosci. 2022 Mar 31;16:854897. Abstract The extracellular matrix (ECM) stabilizes neural circuits and synapses in the healthy brain, while also retaining the ability to be remodeled, to allow synapses to be plastic. A well-described mechanism for ECM
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29.03.2022

Roles and dynamics of 3-methylcytidine in cellular RNAs

Authors Bohnsack KE, Kleiber N, Lemus-Diaz N, Bohnsack MT Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2022 Mar 29:S0968-0004(22)00063-9. Abstract Modified nucleotides within cellular RNAs significantly influence their biogenesis, stability, and function. As reviewed here, 3-methylcytidine (m3C) has recently come to the fore through the identification of the
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28.03.2022

Flexible auditory training, psychophysics, and enrichment of common marmosets with an automated, touchscreen-based system

Authors Calapai A, Cabrera-Moreno J, Moser T, Jeschke M Journal Nature Communications Citation Nat Commun. 2022 Mar 28;13(1):1648. Abstract Devising new and more efficient protocols to analyze the phenotypes of non-human primates, as well as their complex nervous systems, is rapidly becoming of paramount importance. This is because with genome-editing
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12.03.2022

Autosomal dominant non-syndromic hearing loss maps to DFNA33 (13q34) and co-segregates with splice and frameshift variants in ATP11A, a phospholipid flippase gene

Authors Pater JA, Penney C, O’Rielly DD, Griffin A, Kamal L, Brownstein Z, Vona B, Vinkler C, Shohat M, Barel O, French CR, Singh S, Werdyani S, Burt T, Abdelfatah N, Houston J, Doucette LP, Squires J, Glaser F, Roslin NM, Vincent D, Marquis P, Woodland G, Benoukraf T, Hawkey-Noble
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11.03.2022

Methods for multiscale structural and functional analysis of the mammalian cochlea

Authors Vogl C, Neef J, Wichmann C Journal Molecular and Cellular Neuroscience Citation Mol Cell Neurosci. 2022 Mar 11;120:103720. Abstract The mammalian cochlea is a snail-shaped structure deeply that is embedded in the temporal bone and harbors the auditory sensory epithelium – the organ of Corti. Since the discovery of
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10.03.2022

A mathematical model for electrical activity in pig atrial tissue

Authors Peris-Yagüe V, Rubio T, Fakuade FE, Voigt N, Luther S, Majumder R Journal Frontiers in Physiology Citation Front Physiol. 2022 Mar 10;13:812535. Abstract State of the art mathematical models are currently used to bridge the gap between basic research conducted in the laboratory and preclinical research conducted on large
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09.03.2022

Modeling charge separation in charged nanochannels for single-molecule electrometry

Authors Enderlein J, Sakhapov D, Gregor I, Croci M, Karedia N Journal The Journal of Chemical Physics Citation J. Chem. Phys. 156, 105104 (2022) Abstract We model the transport of electrically charged solute molecules by a laminar flow within a nanoslit microfluidic channel with electrostatic surface potential. We derive the governing
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