Research Alliance

Authors Reichmann J, Franz J, Eckermann M, Schulz K, Mollenhauer B, Stadelmann C, Salditt T   Journal MedRxiv   Citation medRxiv 2024.03.26.24304193.   Abstract This study leverages X-ray Phase-Contrast Tomography (XPCT) for detailed analysis of neurodegenerative diseases like Alzheimer’s and Parkinson’s, focusing on the 3D visualization and quantification of neuropathological

Authors Saleem HN, Ignatyeva N, Stuut C, Jakobs S, Habeck M, Ebert A Journal Cells Citation Cells. 2024 May 27;13(11):923. Abstract Intracellular cargo delivery via distinct transport routes relies on vesicle carriers. A key trafficking route distributes cargo taken up by clathrin-mediated endocytosis (CME) via early endosomes. The highly dynamic

Authors Velychko T, Mohammad E, Ferrer-Vicens I, Parfentev I, Werner M, Studniarek C, Schwalb B, Urlaub H, Murphy S, Cramer P, Lidschreiber M Journal Molecular Cell Citation Mol Cell. 2024 May 27:S1097-2765(24)00400-3. Abstract Cyclin-dependent kinase 7 (CDK7), part of the general transcription factor TFIIH, promotes gene transcription by phosphorylating the

Authors Schwenzer N, Teiwes NK, Kohl T, Pohl C, Giller MJ, Lehnart SE, Steinem C Journal Communications Biology Citation Commun Biol. 2024 May 23;7(1):620. Abstract A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3. In the heart, it is required for voltage-dependent

Authors Vučković A, Freyer C, Wredenberg A, Hillen HS Journal Human Molecular Genetics Citation Hum Mol Genet. 2024 May 22;33(R1):R19-R25. Abstract Human mitochondria harbour a circular, polyploid genome (mtDNA) encoding 11 messenger RNAs (mRNAs), two ribosomal RNAs (rRNAs) and 22 transfer RNAs (tRNAs). Mitochondrial transcription produces long, polycistronic transcripts that

Authors Kremer LS, Rehling P Journal Human Molecular Genetics Citation Hum Mol Genet. 2024 May 22;33(R1):R47-R52. Abstract The mitochondrial oxidative phosphorylation (OXPHOS) system produces the majority of energy required by cells. Given the mitochondrion’s endosymbiotic origin, the OXPHOS machinery is still under dual genetic control where most OXPHOS subunits are

Authors Lesmann H, Hustinx A, Moosa S, Klinkhammer H, Marchi E, Caro P, Abdelrazek IM, Pantel JT, Ten Hagen M, Thong MK, Binti Mazlan RA, Tae SK, Kamphans T, Meiswinkel W, Li JM, Javanmardi B, Knaus A, Uwineza A, Knopp C, Tkemaladze T, Elbracht M, Mattern L, Jamra RA, Velmans

Authors Herwerth M, Wyss MT, Schmid NB, Condrau J, Ravotto L, Mateos Melero JM, Kaech A, Bredell G, Thomas C, Stadelmann C, Misgeld T, Bennett JL, Saab AS, Jessberger S, Weber B Journal BioRxiv Citation bioRxiv 2024.05.18.594292. Abstract Mature astrocytes become activated upon non-specific tissue damage and contribute to glial

Authors Zhao DY, Bäuerlein FJB, Saha I, Hartl FU, Baumeister W, Wilfling F Journal Molecular Cell Citation Mol Cell. 2024 May 16;84(10):1980-1994.e8. Abstract Aggregation of proteins containing expanded polyglutamine (polyQ) repeats is the cytopathologic hallmark of a group of dominantly inherited neurodegenerative diseases, including Huntington’s disease (HD). Huntingtin (Htt), the

Authors Zung N, Aravindan N, Boshnakovska A, Valenti R, Preminger N, Jonas F, Yaakov G, Willoughby M, Homberg B, Keller J, Kupervaser M, Dezorella N, Dadosh T, Wolf SG, Itkin M, Malitsky S, Brandis A, Barkai N, Fernandez-Busnadiego R, Reddi A, Rehling P, Rapaport D, Schuldiner M Journal BioRxiv Citation