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02.02.2023

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

Authors Saha I, Yuste-Checa P, Da Silva Padilha M, Guo Q, Körner R, Holthusen H, Trinkaus VA, Dudanova I, Fernández-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Hartl FU, Hipp MS Journal Nature Communications Citation Nat Commun. 2023 Feb 2;14(1):560. Abstract Amyloid-like aggregates of the microtubule-associated protein Tau
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01.02.2023

miR-101a-3p Impairs Synaptic Plasticity and Contributes to Synucleinopathy

Authors Xylaki M, Paiva I, Al-Azzani M, Gerhardt E, Jain G, Islam MR, Vasili E, Wassouf Z, Schulze-Hentrich JM, Fischer A, Outeiro TF Journal Journal of Parkinson’s Disease Citation J Parkinsons Dis. 2023 Feb 1. Abstract Background: Synucleinopathies are disorders characterized by the abnormal accumulation of α-synuclein (aSyn). Synaptic compromise
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27.01.2023

Cholesterol-Induced Nanoscale Variations in the Thickness of Phospholipid Membranes

Authors Chen T, Ghosh A, Enderlein J Journal Nano Letters Citation Nano Lett. 2023 Jan 27. Abstract Graphene-induced energy transfer (GIET) is a recently developed fluorescence-spectroscopic technique that achieves subnanometric optical localization of fluorophores along the optical axis of a microscope. GIET is based on the near-field energy transfer from
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23.01.2023

Towards Unbiased Fluorophore Counting in Superresolution Fluorescence Microscopy

Authors Laitenberger O, Aspelmeier T, Staudt T, Geisler C, Munk A, Egner A Journal Nanomaterials Citation Nanomaterials 2023, 13(3), 459. Abstract With the advent of fluorescence superresolution microscopy, nano-sized structures can be imaged with a previously unprecedented accuracy. Therefore, it is rapidly gaining importance as an analytical tool in the
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23.01.2023

Patient perspectives on the need for improved hearing rehabilitation: A qualitative survey study of German cochlear implant users

Authors Hunniford V, Kühler R, Wolf B, Keppeler D, Strenzke N, Moser T Journal Frontiers in Neuroscience Citation Front. Neurosci. 17:1105562. Abstract Background The electrical cochlear implant (eCI) partially restores hearing in individuals affected by profound hearing impairment (HI) or deafness. However, the limited resolution of sound frequency coding with
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21.01.2023

Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling

Authors Schoger E, Bleckwedel F, Germena G, Rocha C, Tucholla P, Sobitov I, Möbius W, Sitte M, Lenz C, Samak M, Hinkel R, Varga ZV, Giricz Z, Salinas G, Gross JC, Zelarayán LC Journal Communications Biology Citation Commun Biol. 2023 Jan 21;6(1):79. Abstract Aberrant Wnt activation has been reported in failing
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21.01.2023

Simulation of Complex Biomolecular Systems: The Ribosome Challenge

Authors Bock LV, Gabrielli S, Kolá MH, Grubmüller H   Journal Annual Review of Biophysics   Citation Annu. Rev. Biophys. 2023. 52:15.1–15.30.   Abstract Large biomolecular systems are at the heart of many essential cellular processes. The dynamics and energetics of an increasing number of these systems are being studied
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19.01.2023

Graded optogenetic activation of the auditory pathway for hearing restoration

Authors Mittring A, Moser T, Huet AT Journal Brain Stimulation Citation Brain Stimul. 2023 Jan 23:S1935-861X(23)01673-X. Abstract Optogenetic control of neural activity enables innovative approaches to improve functional restoration of diseased sensory and motor systems. For clinical translation to succeed, optogenetic stimulation needs to closely match the coding properties of
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18.01.2023

Impact of the Euro 2020 championship on the spread of COVID-19

Authors Dehning J, Mohr SB, Contreras S, Dönges P, Iftekhar EN, Schulz O, Bechtle P, Priesemann V Journal Nature Communications Citation Nat Commun 14, 122 (2023). Abstract Large-scale events like the UEFA Euro 2020 football (soccer) championship offer a unique opportunity to quantify the impact of gatherings on the spread
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15.01.2023

Uncovering the molecular link between lead toxicity and Parkinson’s disease

Authors Shvachiy L, Geraldes V, Outeiro TF Journal Antioxidants & Redox Signaling Citation Antioxidants & Redox Signaling. 2023. Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder that affects millions around the world. The etiology of PD remains unknown, but environmental and ocuppational exposures to heavy metals are likely at
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