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10.01.2023

Translation Factor Accelerating Peptide Bond Formation on the Ribosome: EF-P and eIF5A as Entropic Catalysts and a Potential Drug Targets

Authors Mudryi V, Peske F, Rodnina M Journal BBA Advances Citation BBA Adv. 2023 Jan 10;3:100074. Abstract Elongation factor P (EF-P) and its eukaryotic homolog eIF5A are auxiliary translation factors that facilitate peptide bond formation when several sequential proline (Pro) residues are incorporated into the nascent chain. EF-P and eIF5A
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10.01.2023

Trafficking proteins show limited differences in mobility across different postsynaptic spines

Authors Mougios N, Opazo F, Rizzoli SO, Reshetniak S Journal iScience Citation iScience (2023). Abstract The function of the postsynaptic compartment is based on the presence and activity of postsynaptic receptors, whose dynamics are controlled by numerous scaffolding, signaling and trafficking proteins. While the receptors and the scaffolding proteins have
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04.01.2023

Multimodal epigenetic changes and altered NEUROD1 chromatin binding in the mouse hippocampus underlie FOXG1 syndrome

Authors Akol I, Izzo A, Gather F, Strack S, Heidrich S, Ó hAilín D, Villarreal A, Hacker C, Rauleac T, Bella C, Fischer A, Manke T, Vogel T Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A.
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28.12.2022

Expanding the spectrum of EEF1D neurodevelopmental disorders: Biallelic variants in the Guanine Exchange Domain

Authors Averdunk L, Al-Thihli K, Surowy H, Lüdecke HJ, Drechsler M, Yigit G, Smorag L, Hallak BA, Li Y, Altmüller J, Guthoff T, Wallot M, Nürnberg P, Wollnik B, Abou Jamra R, Al-Maawali A, Wieczorek D Journal Clinical Genetics Citation Clin Genet. 2022 Dec 28. Abstract Protein translation is an
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27.12.2022

Multi-color live-cell STED nanoscopy of mitochondria with a gentle inner membrane stain

Authors Liu T, Stephan T, Chen P, Keller-Findeisen J, Chen J, Riedel D, Yang Z, Jakobs S, Chen Z Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2022 Dec 27;119(52):e2215799119. Abstract Capturing mitochondria’s intricate and dynamic
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23.12.2022

Dystrophin is a mechanical tension modulator

Authors Hofemeier AD, Muenker TM, Herkenrath F, Ristau M, Brandt M, Shahriyari M, Tiburcy M, Zimmermann WH, Lenz C, Mamchaoui K, Bigot A, Gilbert PM, Betz T Journal BioRxiv Citation bioRxiv 2022.12.23.521750. Abstract Duchenne muscular dystrophy (DMD) represents the most common inherited muscular disease, where increasing muscle weakness leads to
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23.12.2022

Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses

Authors Chakrabarti R, Jaime Tobón LM, Slitin L, Redondo-Canales M, Hoch G, Slashcheva M, Fritsch E, Bodensiek K, Özçete ÖD, Gültas M, Michanski S, Opazo F, Neef J, Pangrsic T, Moser T, Wichmann C Journal elife Citation Elife. 2022 Dec 23;11:e79494. Abstract RRibbon synapses of cochlear inner hair cells (IHCs)
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22.12.2022

On the Fabrication and Characterization of Polymer-Based Waveguide Probes for Use in Future Optical Cochlear Implants

Authors Helke C, Reinhardt M, Arnold M, Schwenzer F, Haase M, Wachs M, Goßler C, Götz J, Keppeler D, Wolf B, Schaeper J, Salditt T, Moser T, Schwarz UT, Reuter D Journal Materials (Basel) Citation Materials (Basel). 2022 Dec 22;16(1):106. Abstract Improved hearing restoration by cochlear implants (CI) is expected
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16.12.2022

Molecular Mechanisms Mediating the Transfer of Disease-Associated Proteins and Effects on Neuronal Activity

Authors Brás IC, Khani MH, Vasili E, Möbius W, Riedel D, Parfentev I, Gerhardt E, Fahlbusch C, Urlaub H, Zweckstetter M, Gollisch T, Outeiro TF Journal Journal of Parkinson’s Disease Citation J Parkinsons Dis. 2022;12(8):2397-2422. Abstract Background: Various cellular pathways have been implicated in the transfer of disease-related proteins between
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12.12.2022

Mono- and Intralink Filter (Mi-Filter) To Reduce False Identifications in Cross-Linking Mass Spectrometry Data

Authors Chen X, Sailer C, Kammer KM, Fürsch J, Eisele MR, Sakata E, Pellarin R, Stengel F Journal Analytical Chemistry Citation Anal. Chem. 2022, 94, 51, 17751–17756. Abstract Cross-linking mass spectrometry (XL-MS) has become an indispensable tool for the emerging field of systems structural biology over the recent years. However,
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