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09.12.2022

Free-Breathing Liver Fat, R*2 and B0 Field Mapping Using Multi-Echo Radial FLASH and Regularized Model-based Reconstruction

Authors Tan Z, Unterberg-Buchwald C, Blumenthal M, Scholand N, Schaten P, Holme C, Wang X, Raddatz D, Uecker M   Journal IEEE Transactions on Medical Imaging   Citation IEEE Trans Med Imaging. 2022 Dec 9;PP. Abstract This work introduced a stack-of-radial multi-echo asymmetric-echo MRI sequence for free-breathing liver volumetric acquisition.
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08.12.2022

Postmortem quantitative MRI disentangles histological lesion types in multiple sclerosis

Authors Galbusera R, Bahn E, Weigel M, Schaedelin S, Franz J, Lu PJ, Barakovic M, Melie-Garcia L, Dechent P, Lutti A, Sati P, Reich DS, Nair G, Brück W, Kappos L, Stadelmann C, Granziera C. Journal Brain Pathology Citation Brain Pathol. 2022 Dec 8:e13136. Abstract Quantitative MRI (qMRI) probes the
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07.12.2022

Artificial peptides to induce membrane denaturation and disruption and modulate membrane composition and fusion

Authors Lāce I, Cotroneo ER, Hesselbarth N, Simeth NA Journal Journal of Peptide Science Citation J Pept Sci. 2022 Dec 7:e3466. Abstract Membranes consisting of phospholipid bilayers are an essential constituent of eukaryotic cells and their compartments. The alteration of their composition, structure and morphology plays an important role in
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06.12.2022

Targeting Mitochondrial Calcium Handling to Treat Atrial Fibrillation

Authors Voigt N, Maack C, Pronto JRD Journal Journal of the American College of Cardiology Citation J Am Coll Cardiol. 2022 Dec, 80 (23) 2220–2223. Abstract No abstract available DOI 10.1016/j.jacc.2022.09.043   Pubmed Link
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29.11.2022

Sampling effects and measurement overlap can bias the inference of neuronal avalanches

Authors Pinheiro Neto J, Spitzner FP, Priesemann V Journal PLoS Computational Biology Citation PLoS Comput Biol 18(11): e1010678. Abstract To date, it is still impossible to sample the entire mammalian brain with single-neuron precision. This forces one to either use spikes (focusing on few neurons) or to use coarse-sampled activity
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24.11.2022

Structural basis of SNAPc-dependent snRNA transcription initiation by RNA polymerase II

Authors Rengachari S, Schilbach S, Kaliyappan T, Gouge J, Zumer K, Schwarz J, Urlaub H, Dienemann C, Vannini A, Cramer P Journal Nature Structural and Molecular Biology Citation Nat Struct Mol Biol. 2022 Nov 24. Abstract RNA polymerase II (Pol II) carries out transcription of both protein-coding and non-coding genes.
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23.11.2022

Regulation of the mammalian-brain V-ATPase through ultraslow mode-switching

Authors Kosmidis E, Shuttle CG, Preobraschenski J, Ganzella M, Johnson PJ, Veshaguri S, Holmkvist J, Møller MP, Marantos O, Marcoline F, Grabe M, Pedersen JL, Jahn R, Stamou D Journal Nature Citation Nature. 2022 Nov;611(7937):827-834. Abstract Vacuolar-type adenosine triphosphatases (V-ATPases)1,2,3 are electrogenic rotary mechanoenzymes structurally related to F-type ATP synthases4,5.
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21.11.2022

Structures of transcription preinitiation complex engaged with the +1 nucleosome

Authors Wang H, Schilbach S, Ninov M, Urlaub H, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2022 Nov 21. Abstract The preinitiation complex (PIC) assembles on promoters of protein-coding genes to position RNA polymerase II (Pol II) for transcription initiation. Previous structural studies revealed
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20.11.2022

Free-Breathing Myocardial T1 Mapping using Inversion-Recovery Radial FLASH and Motion-Resolved Model-Based Reconstruction

Authors Wang X, Rosenzweig S, Roeloffs V, Blumenthal M, Scholand N, Tan Z, Holme HCM, Unterberg-Buchwald C, Hinkel R, Uecker M Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2022 Nov 20. Abstract Purpose: To develop a free-breathing myocardial T1 mapping technique using inversion-recovery (IR) radial fast low-angle shot
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18.11.2022

Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones

Authors Tan C, de Nola G, Qiao C, Imig C, Born RT, Brose N, Kaeser PS Journal eLife Citation eLife 11:e79077. Abstract Active zones consist of protein scaffolds that are tightly attached to the presynaptic plasma membrane. They dock and prime synaptic vesicles, couple them to voltage-gated Ca2+ channels, and
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