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16.11.2022

Somatic mosaicism in STAG2-associated cohesinopathies: Expansion of the genotypic and phenotypic spectrum

Authors Schmidt J, Dreha-Kulaczewski S, Zafeiriou MP, Schreiber MK, Wilken B, Funke R, Neuhofer CM, Altmüller J, Thiele H, Nürnberg P, Biskup S, Li Y, Zimmermann WH, Kaulfuß S, Yigit G, Wollnik B. Journal Frontiers in Cell and Developmental Biology Citation Front Cell Dev Biol. 2022 Nov 16;10:1025332. Abstract STAG2
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12.11.2022

Inflammation and vascular remodeling in COVID-19 hearts

Authors Werlein C, Ackermann M, Stark H, Shah HR, Tzankov A, Haslbauer JD, von Stillfried S, Bülow RD, El-Armouche A, Kuenzel S, Robertus JL, Reichardt M, Haverich A, Höfer A, Neubert L, Plucinski E, Braubach P, Verleden S, Salditt T, Marx N, Welte T, Bauersachs J, Kreipe HH, Mentzer SJ,
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10.11.2022

The 3D structure of lipidic fibrils of α-synuclein

Authors Frieg B, Antonschmidt L, Dienemann C, Geraets JA, Najbauer EE, Matthes D, de Groot BL, Andreas LB, Becker S, Griesinger C, Schröder GF Journal Nature Communications Citation Nat Commun. 2022 Nov 10;13(1):6810. Abstract α-synuclein misfolding and aggregation into fibrils is a common feature of α-synucleinopathies, such as Parkinson’s disease,
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10.11.2022

Focused ion beam-scanning electron microscopy links pathological myelin outfoldings to axonal changes in mice lacking Plp1 or Mag

Authors Steyer AM, Buscham TJ, Lorenz C, Hümmert S, Eichel-Vogel MA, Schadt LC, Edgar JM, Köster S, Möbius W, Nave KA, Werner HB Journal Glia Citation Glia. 2022 Nov 10. Abstract Healthy myelin sheaths consist of multiple compacted membrane layers closely encasing the underlying axon. The ultrastructure of CNS myelin
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09.11.2022

Generation of bright autobioluminescent bacteria by chromosomal integration of the improved lux operon ilux2

Authors Gregor C Journal Scientific Reports Citation Sci Rep. 2022 Nov 9;12(1):19039. Abstract The bacterial bioluminescence system enables the generation of light by living cells without the requirement of an external luciferin. Due to the relatively low light emission, many applications of bioluminescence imaging would benefit from an increase in
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07.11.2022

Kantorovich–Rubinstein Distance and Barycenter for Finitely Supported Measures: Foundations and Algorithms

Authors Heinemann F, Klatt M, Munk A Journal Applied Mathematics & Optimization Citation Appl Math Optim 87, 4 (2023). Abstract The purpose of this paper is to provide a systematic discussion of a generalized barycenter based on a variant of unbalanced optimal transport (UOT) that defines a distance between general
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31.10.2022

Peptide Conjugated Dihydroazulene/Vinylheptafulvene Photoswitches in Aqueous Environment

Authors Corbet BP, Schlüter JM, Cotroneo ER, Crespi S, Simeth NA Journal European Journal of Organic Chemistry Citation Eur. J. Org. Chem. 2022, e202201140 Abstract Light-responsive molecules have seen a major advance in modulating biological functions in recent years. Especially photoswitches are highly attractive building blocks due to the reversible
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27.10.2022

Human mtRF1 terminates COX1 translation and its ablation induces mitochondrial ribosome-associated quality control

Authors Nadler F, Lavdovskaia E, Krempler A, Cruz-Zaragoza LD, Dennerlein S, Richter-Dennerlein R Journal Nature Communications Citation Nat Commun. 2022 Oct 27;13(1):6406. Abstract Translation termination requires release factors that read a STOP codon in the decoding center and subsequently facilitate the hydrolysis of the nascent peptide chain from the peptidyl
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25.10.2022

Cochlear Hair Cell Innervation is Dependent on a Modulatory Function of Semaphorin-3A

Authors Cantu-Guerra HL, Papazian MR, Gorsky AL, Alekos NS, Caccavano A, Karagulyan N, Neef J, Vicini S, Moser T, Coate TM Journal Developmental Dynamics Citation Dev Dyn. 2022 Oct 25. Abstract Background: Proper connectivity between type I spiral ganglion neurons (SGNs) and inner hair cells (IHCs) in the cochlea is
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22.10.2022

Lost in promiscuity? An evolutionary and biochemical evaluation of HSD10 function in cardiolipin metabolism

Authors Wohlfarter Y, Eidelpes R, Yu RD, Sailer S, Koch J, Karall D, Scholl-Bürgi S, Amberger A, Hillen HS, Zschocke J, Keller MA Journal Cellular and Molecular Life Sciences Citation Cell Mol Life Sci. 2022 Oct 22;79(11):562. Abstract Multifunctional proteins are challenging as it can be difficult to confirm pathomechanisms
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