Communications Biology

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02.04.2025

Power-law adaptation in the presynaptic vesicle cycle

Authors Mikulasch FA, Georgiev SV, Rudelt L, Rizzoli SO, Priesemann V Journal Communications Biology Citation Commun Biol. 2025 Apr 2;8(1):542. Abstract After synaptic transmission, fused synaptic vesicles are recycled, enabling the synapse to recover its capacity for renewed release. The recovery steps, which range from endocytosis to vesicle docking and
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26.03.2025

Microtubules as a versatile reference standard for expansion microscopy

Authors Chowdhury R, Mimoso T, Chouaib AA, Mougios N, Krah D, Opazo F, Köster S, Rizzoli SO, Shaib AH Journal Communications Biology Citation Commun Biol. 2025 Mar 26;8(1):499. Abstract Expansion microscopy (ExM) is continually improving, and new ExM variants need to be validated on well-defined biological structures. There is no
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30.11.2024

Observation of E-cadherin adherens junction dynamics with metal-induced energy transfer imaging and spectroscopy

Authors Chen T, Karedla N, Enderlein J Journal Communications Biology Citation Commun Biol. 2024 Nov 30;7(1):1596. Abstract Epithelial cadherin (E-cad) mediated cell-cell junctions play a crucial role in the establishment and maintenance of tissues and organs. In this study, we employed metal-induced energy transfer imaging and spectroscopy to investigate variations
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17.09.2024

Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation

Authors Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, Brose N, Taschenberger H, Krueger-Burg D Journal Communications Biology Citation Commun Biol. 2024 Sep 17;7(1):1157. Abstract Neuroligin-2 (Nlgn2) is a key synaptic adhesion protein at virtually all
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13.09.2024

MultiMatch: Geometry-Informed Colocalization in Multi-Color Super-Resolution Microscopy

Authors Naas J, Nies G, Li H, Stoldt S, Schmitzer B, Jakobs S, Munk A Journal Communications Biology Citation Commun Biol 7, 1139 (2024). Abstract With recent advances in multi-color super-resolution light microscopy, it is possible to simultaneously visualize multiple subunits within biological structures at nanometer resolution. To optimally evaluate
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23.05.2024

CaV1.3 channel clusters characterized by live-cell and isolated plasma membrane nanoscopy

Authors Schwenzer N, Teiwes NK, Kohl T, Pohl C, Giller MJ, Lehnart SE, Steinem C Journal Communications Biology Citation Commun Biol. 2024 May 23;7(1):620. Abstract A key player of excitable cells in the heart and brain is the L-type calcium channel CaV1.3. In the heart, it is required for voltage-dependent
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21.06.2023

Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues

Authors Nakhaei-Rad S, Haghighi F, Bazgir F, Dahlmann J, Busley AV, Buchholzer M, Kleemann K, Schänzer A, Borchardt A, Hahn A, Kötter S, Schanze D, Anand R, Funk F, Kronenbitter AV, Scheller J, Piekorz RP, Reichert AS, Volleth M, Wolf MJ, Cirstea IC, Gelb BD, Tartaglia M, Schmitt JP, Krüger
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21.01.2023

Single-cell transcriptomics reveal extracellular vesicles secretion with a cardiomyocyte proteostasis signature during pathological remodeling

Authors Schoger E, Bleckwedel F, Germena G, Rocha C, Tucholla P, Sobitov I, Möbius W, Sitte M, Lenz C, Samak M, Hinkel R, Varga ZV, Giricz Z, Salinas G, Gross JC, Zelarayán LC Journal Communications Biology Citation Commun Biol. 2023 Jan 21;6(1):79. Abstract Aberrant Wnt activation has been reported in failing
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15.09.2022

A modern automated patch-clamp approach for high throughput electrophysiology recordings in native cardiomyocytes

Authors Seibertz F, Rapedius M, Fakuade FE, Tomsits P, Liutkute A, Cyganek L, Becker N, Majumder R, Clauß S, Fertig N, Voigt N. Journal Communications Biology Citation Commun Biol 2022 Sep 15;5(1):969. Abstract Crucial conventional patch-clamp approaches to investigate cellular electrophysiology suffer from low-throughput and require considerable experimenter expertise. Automated
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11.01.2022

Fluorescence lifetime DNA-PAINT for multiplexed super-resolution imaging of cells

Authors Oleksiievets N, Sargsyan Y, Thiele JC, Mougios N, Sograte-Idrissi S, Nevskyi O, Gregor I, Opazo F, Thoms S, Enderlein J, Tsukanov R Journal Communications Biology Citation Commun Biol 5, 38 (2022). Abstract DNA point accumulation for imaging in nanoscale topography (DNA-PAINT) is a powerful super-resolution technique highly suitable for
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