Hasenfuß, Gerd

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22.01.2024

Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants

Authors Knauer C, Haltern H, Schoger E, Kügler S, Roos L, Zelarayán LC, Hasenfuss G, Zimmermann WH, Wollnik B, Cyganek L Journal Molecular Therapy: Nucleic Acids Citation Mol Ther Nucleic Acids. 2024 Jan 23;35(1):102123. Abstract Gene variants in LZTR1 are implicated to cause Noonan syndrome associated with a severe and
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05.01.2024

Noninvasive analysis of contractility during identical maturations revealed two phenotypes in ventricular but not in atrial iPSC-CM

Authors Rapöhn M, Cyganek L, Voigt N, Hasenfuß G, Lehnart SE, Wegener JW Journal American Journal of Physiology. Heart and Circulatory Physiology Citation Am J Physiol Heart Circ Physiol. 2024 Jan 5. Abstract Patient-derived induced pluripotent stem cells (iPSC) can be differentiated into atrial and ventricular cardiomyocytes to allow for
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11.09.2023

Low levels of circulating methylated IRX3 are related to worse outcome after transcatheter aortic valve implantation in patients with severe aortic stenosis

Authors Kanwischer L, Xu X, Saifuddin AB, Maamari S, Tan X, Alnour F, Tampe B, Meyer T, Zeisberg M, Hasenfuss G, Puls M, Zeisberg EM Journal Clinical Epigenetics Citation Clin Epigenetics. 2023 Sep 11;15(1):149. Abstract Background: Aortic stenosis (AS) is one of the most common cardiac diseases and major cause
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14.06.2023

An Alternative Mechanism of Subcellular Iron Uptake Deficiency in Cardiomyocytes

Authors Dai Y, Ignatyeva N, Xu H, Wali R, Toischer K, Brandenburg S, Lenz C, Pronto J, Fakuade FE, Sossalla S, Zeisberg EM, Janshoff A, Kutschka I, Voigt N, Urlaub H, Rasmussen TB, Mogensen J, Lehnart SE, Hasenfuss G, Ebert A Journal Circulation Research Citation Circ Res. 2023 Jun 14.
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10.01.2023

LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

Authors Busley AV, Gutiérrez-Gutiérrez O, Hammer E, Steinegger M, Böhmer L, Schroeder H, Kleinsorge M, Altmüller J, Marbach F, Hasenfuss G, Zimmermann WH, Wollnik B, Cyganek L Journal BioRxiv Citation bioRxiv 2023.01.10.523203. Abstract Noonan syndrome patients harboring causative variants in LZTR1 are particularly at risk to develop severe and early-onset
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06.09.2022

Direct proteomic and high-resolution microscopy biopsy analysis identifies distinct ventricular fates in severe aortic stenosis

Authors Brandenburg S, Otto L, Schönberger HL, Jacob CF, Paulke NJ, Beuthner BE, Topci R, Kohl T, Neuenroth L, Kutschka I, Urlaub H, Kück F, Leha A, Friede T, Seidler T, Jacobshagen C, Toischer K, Puls M, Hasenfuß G, Lenz C, Lehnart SE Journal Journal of Molecular and Cellular Cardiology
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28.07.2022

Functional and structural reverse myocardial remodeling following transcatheter aortic valve replacement: a prospective cardiovascular magnetic resonance study

Authors Lange T, Backhaus SJ, Beuthner BE, Topci R, Rigorth KR, Kowallick JT, Evertz R, Schnelle M, Ravassa S, Díez J, Toischer K, Seidler T, Puls M, Hasenfuß G, Schuster A Journal Journal of Cardiovascular Magnetic Resonance Citation J Cardiovasc Magn Reson. 2022 Jul 28;24(1):45. Abstract Background: Since cardiovascular magnetic
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08.03.2022

Doxorubicin induces cardiotoxicity in a pluripotent stem cell model of aggressive B cell lymphoma cancer patients

Authors Haupt LP, Rebs S, Maurer W, Hübscher D, Tiburcy M, Pabel S, Maus A, Köhne S, Tappu R, Haas J, Li Y, Sasse A, Santos CCX, Dressel R, Wojnowski L, Bunt G, Möbius W, Shah AM, Meder B, Wollnik B, Sossalla S, Hasenfuss G, Streckfuss-Bömeke K Journal Basic Research
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13.01.2022

A junctional cAMP compartment regulates rapid Ca2+ signaling in atrial myocytes

Authors Brandenburg S, Pawlowitz J, Steckmeister V, Subramanian H, Uhlenkamp D, Scardigli M, Mushtaq M, Amlaz SI, Kohl T, Wegener JW, Arvanitis DA, Sanoudou D, Sacconi L, Hasenfuß G, Voigt N, Nikolaev VO, Lehnart SE Journal Journal of Molecular and Cellular Cardiology Citation J Mol Cell Cardiol. 2022 Jan 13;165:141-157.
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09.12.2021

The RyR2-R2474S Mutation Sensitizes Cardiomyocytes and Hearts to Catecholaminergic Stress-Induced Oxidation of the Mitochondrial Glutathione Pool

Authors Wegener JW, Wagdi A, Wagner E, Katschinski DM, Hasenfuss G, Bruegmann T, Lehnart SE Journal Frontiers in Physiology Citation Front Physiol. 2021 Dec 9;12:777770. Abstract Missense mutations in the cardiac ryanodine receptor type 2 (RyR2) characteristically cause catecholaminergic arrhythmias. Reminiscent of the phenotype in patients, RyR2-R2474S knockin mice develop
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