Research Alliance

Authors Paternoga H, Crowe-McAuliffe C, Bock LV, Koller TO, Morici M, Beckert B, Myasnikov AG, Grubmüller H, Nováček J, Wilson DN Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol (2023). Abstract The ribosome is a major target for clinically used antibiotics, but multidrug resistant pathogenic bacteria are

Authors Chopra A, Outeiro TF Journal Brain Citation Brain. 2023 Aug 1:awad260. Abstract Parkinson’s disease is clinically known for the loss of dopaminergic neurons in the substantia nigra pars compacta and accumulation of intraneuronal cytoplasmic inclusions rich in alpha-synuclein called ‘Lewy bodies’ and ‘Lewy neurites’. Together with dementia with Lewy

Authors Warth Perez Arias CC, Silbern I, Caldi Gomes L, Wartmann H, Dambeck V, Fanz J, Neuenroth L, Bähr M, Outeiro TF, Bonn S, Stadelmann-Nessler C, Rizzoli SO, Lenz C, Urlaub H, Lingor P Journal Journal of Neurochemistry Citation J Neurochem. 2023 Jul 28. Abstract Parkinson’s disease (PD) affects a

Authors Zelená A, Blumberg J, Probst D, Gerasimaitė R, Lukinavicius G, Schwarz US, Köster S Journal Biophysical Journal Citation Biophys J. 2023 Jul 19:S0006-3495(23)00461-7. Abstract Blood platelets are central elements of the blood clotting response after wounding. Upon vessel damage, they bind to the surrounding matrix and contract the forming

Authors Wong KM, Wegener E, Baradaran-Heravi A, Huppke B, Gärtner J, Huppke P Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2023 Jul 19;24(14):11665. Abstract Rett syndrome (RTT), a severe X-linked neurodevelopmental disorder, is primarily caused by mutations in the methyl CpG binding protein 2 gene (MECP2).

Authors Pohlmann M, Werner F, Munk A Journal Information and Inference: A Journal of the IMA Citation Information and Inference: A Journal of the IMA, Volume 12, Issue 3, September 2023, iaad026. Abstract We investigate minimax testing for detecting local signals or linear combinations of such signals when only indirect

Authors Toy S, Dietz J, Naumann P, Trothe J, Thomas F, Diederichsen U, Steinem C, Janshoff A Journal Chemistry Citation Chemistry. 2023 Jul 11;29(39):e202203904. Abstract Cell adhesion molecules are crucial for a variety of biological processes, including wound healing, barrier formation and tissue homeostasis. One of them is E-cadherin which

Authors Toy S, Dietz J, Naumann P, Trothe J, Thomas F, Diederichsen U, Steinem C, Janshoff A Journal Chemistry – A European Journal Citation Chemistry. 2023 Jul 11;29(39):e202203904 Abstract Cell adhesion molecules are crucial for a variety of biological processes, including wound healing, barrier formation and tissue homeostasis. One of

Authors Markus MA, Ferrari DP, Alves F, Ramos-Gomes F Journal Biomedical Optics Express Citation Biomed. Opt. Express 14, 3988-4002 (2023). Abstract Fixation methods such as formalin are commonly used for the preservation of tissue with the aim of keeping their structure as close as possible to the native condition. However,

Authors Flores-Leon M, Outeiro TF Journal Acta Neuropathologica Citation Acta Neuropathol. 2023 Jul 8. Abstract The accumulation of proteinaceous inclusions in the brain is a common feature among neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease (PD), and dementia with Lewy bodies (DLB). The main neuropathological hallmark of PD and