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Authors Neher E, Taschenberger H Journal Neuroscience Citation Neuroscience. 2021 Mar 15;458:182-202. Abstract Synaptic vesicles (SVs) undergo multiple steps of functional maturation (priming) before being fusion competent. We present an analysis technique, which decomposes the time course of quantal release during repetitive stimulation as a sum of contributions of SVs,

Authors Weber M, Leutenegger M, Stoldt S, Jakobs S, Mihaila TS, Butkevich AN, Hell SW Journal Nature Photonics Citation Nat. Photonics 15, 361–366 (2021). Abstract We introduce MINSTED, a fluorophore localization and super-resolution microscopy concept based on stimulated emission depletion (STED) that provides spatial precision and resolution down to the

Authors Huet AT, Dombrowsik T, Rankovic V, Thirumalai A, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 14:635897. Abstract Optogenetic stimulation of type I spiral ganglion neurons (SGNs) promises an alternative to the electrical stimulation by current cochlear implants (CIs) for improved hearing restoration by future optical

Authors Hoffmann S, Schmitteckert S, Raedecke K, Rheinert D, Diebold S, Roeth R, Weiss B, Granzow M, Niesler B, Griesbeck A, Eckstein V, Zimmermann WH, Just S, Rappold GA Journal Biochimica et Biophysica Acta – Gene Regulatory Mechanisms Citation Biochim Biophys Acta Gene Regul Mech. 2021 Mar 8:194702. Abstract The

Authors Reshetniak S, Rizzoli SO Journal Current Opinion in Cell Biology Citation Curr Opin Cell Biol. 2021 Mar 8;71:63-68. Abstract For decades, the synaptic vesicle cluster has been thought of as a storage space for synaptic vesicles, whose obvious function is to provide vesicles for the depolarization-induced release of neurotransmitters;

Authors Martinez-Sanchez A, Laugks U, Kochovski Z, Papantoniou C, Zinzula L, Baumeister W, Lučić V Journal Science Advances Citation Sci Adv. 2021 Mar 5;7(10):eabe6204. Abstract   Synaptic transmission is characterized by fast, tightly coupled processes and complex signaling pathways that require a precise protein organization, such as the previously reported

Authors Bartsch A, Ives CM, Kattner C, Pein F, Diehn M, Tanabe M, Munk A, Zachariae U, Steinem C, Llabrés S Journal Biochimica et Biophysica Acta – Biomembranes Citation Biochim Biophys Acta Biomembr. 2021 Mar 3:183601. Abstract Gram-negative bacteria cause the majority of highly drug-resistant bacterial infections. To cross the

Authors Medina L, González-Lizárraga F, Dominguez-Meijide A, Ploper D, Parrales V, Sequeira S, Cima-Omori MS, Zweckstetter M, Del Bel E, Michel PP, Outeiro TF, Raisman-Vozari R, Chehín R, Socias SB Journal Frontiers in Aging Neuroscience Citation Front Aging Neurosci. 2021 Mar 22;13:635760. Abstract Tauopathies are neurodegenerative disorders with increasing incidence

Authors Sakata E, Eisele MR, Baumeister W Journal Biochimica et Biophysica Acta – Proteins and Proteomics Citation Biochim Biophys Acta Proteins Proteom. 2021 Mar;1869(3):140583. Epub 2020 Dec 13. Abstract In eukaryotic cells, the ubiquitin-proteasome system serves to remove proteins that are either dysfunctional or no longer needed. The 26S proteasome

Authors Outeiro TF Journal Acta Neuropathologica (Editorial) Citation Acta Neuropathol. 2021 Feb 24. Abstract No abstract available DOI 10.1007/s00401-021-02290-7 Pubmed Link