2025

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03.07.2025

Lamin variants cause cardiac arrhythmogenicity in Drosophila

Authors van Wijk SW, Vree P, Huiskes FG, van der Palen RL, Liutkute A, Voigt N, Wallrath LL, Brundel BJJM Journal Disease Models and Mechanism Citation Dis Model Mech. 2025 Jul 3:dmm.052424. Abstract Atrial fibrillation (AF), the most common progressive cardiac arrhythmia, is associated with serious complications such as stroke
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01.07.2025

Fluorinated Phenylazopyrazoles for Monitoring the Photoisomerization in Complex Systems

Authors Jakob L, van der Wal JJ, Tovtik R, Copko J, Iagatti A, Donato MD, Crespi S, Simeth NA Journal Chemistry – A European Journal Citation Chemistry. 2025 Jul 1:e202501856. Abstract Photoswitches have been impacting diverse areas of research, introducing means of dynamically regulating their environment through reversible photochemical isomerization.
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21.06.2025

Testosterone and atrial fibrillation: does the dose make the poison?

Authors Mason FE, Liutkute A, Voigt N Journal Cardiovascular Research Citation Cardiovasc Res. 2025 Jun 21:cvaf113. Abstract No abstract available. DOI 10.1093/cvr/cvaf113   Pubmed Link
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20.06.2025

The lincRNA Pantr1 is a FOXG1 target gene conferring site-specific chromatin binding of FOXG1

Authors Gather F, Rauleac T, Akol I, Arumugam G, Fullio CL, Müller T, Kleidonas D, Geiss-Friedlander R, Fischer A, Vlachos A, Backofen R, Vogel T Journal Nucleic Acids Research Citation Nucleic Acids Res. 2025 Jun 20;53(12):gkaf539. Abstract Derailed gene expression programs within the developing nervous system, encompassing both transcriptional and
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18.06.2025

Gating of hair cell Ca2+ channels governs the activity of cochlear neurons

Authors Karagulyan N, Thirumalai A, Michanski S, Qi Y, Fang Q, Wang H, Ortner NJ, Striessnig J, Strenzke N, Wichmann C, Hua Y, Moser T Journal Science Advances Citation Sci Adv. 2025 Jun 20;11(25):eadu7898. Abstract Our sense of hearing processes sound intensities spanning six orders of magnitude. In the ear,
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16.06.2025

Mitotic BLM functions are required to maintain genomic stability

Authors Hamann TE, Wieland A, Tirincsi A, Vukusic K, Mohseni F, Wardenaar R, Losito M, Goenenc II, Wollnik B, Foijer F, Tolic IM, Storchova Z, Raschle M Journal BioRxiv Citation bioRxiv 2025.06.16.659902. Abstract The BLM helicase is a critical genome maintenance protein involved in diverse cellular processes including DNA replication,
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12.06.2025

Role of Compensatory miRNA Networks in Cognitive Recovery from Heart Failure

Authors Gisa V, Islam MR, Lbik D, Hofmann RM, Pena T, Krüger DM, Burkhardt S, Schütz AL, Sananbenesi F, Toischer K, Fischer A Journal Non-coding RNA Citation Noncoding RNA. 2025 Jun 12;11(3):45. Abstract Background: Heart failure (HF) is associated with an increased risk of cognitive impairment and hippocampal dysfunction, yet
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11.06.2025

The amyloid precursor family of proteins in excitatory neurons are essential for regulating cortico-hippocampal circuit dynamics in vivo

Authors Harris SS, Rajani RM, Zünkler J, Ellingford R, Yang M, Rowland JM, Schmidt A, Lee BI, Kehring M, Hellmuth M, Lam FKW, Fässler D, Erdinger S, Wolfer DP, Sala Frigerio C, Wolf F, Hyman BT, Müller UC, Busche MA Journal Cell Reports Citation Cell Rep. 2025 Jun 11;44(6):115801. Abstract
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10.06.2025

Disease Severity Across Psychiatric Disorders Is Linked to Pro-Inflammatory Cytokines

Authors Solomon P, Budde M, Kohshour MO, Adorja K, Heilbronner M, Navarro-Flores A, Papiol S, Reich-Erkelenz D, Schulte EC, Senner F, Vogl T, Kaurani L, Krüger DM, Sananbenesi F, Pena T, Burkhardt S, Schütz AL, Anghelescu IG, Arolt V, Baune BT, Dannlowski U, Dietrich DE, Fallgatter AJ, Figge C, Juckel
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10.06.2025

Dual effect of alpha-synuclein disease variants on condensate formation

Authors Chandran A, Agarwal A, Wang T, Amaral L, Chaves SR, Outeiro TF, Lautenschlager J Journal BioRxiv Citation bioRxiv 2025.06.06.657340. Abstract Alpha-synuclein is a pre-synaptic protein implicated in synucleinopathies like Parkinson’s disease and Dementia with Lewy Bodies, where it accumulates in intracellular aggregates termed Lewy bodies and Lewy neurites. Recent
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