2025

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30.05.2025

Sarcomere analysis in human cardiomyocytes by computing radial frequency spectra

Authors Habeck M, Saleem N, Plota D, Cheruiyot C, Kohl T, Lehnart S, Jakobs S, Ebert A Journal BioRxiv Citation bioRxiv 2025.05.28.655290. Abstract In cardiomyocytes, the basic contractile unit are sarcomeres, which are organized in a regular manner facilitating their function. Here, we present a new computational approach to assess
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28.05.2025

Continuous dynamics of cooperation and competition in social decision-making

Authors Lewen D, Ivanov V, Dehning J, Ruß J, Fischer A, Penke L, Schacht A, Gail A, Priesemann V, Kagan I Journal BioRxiv Citation bioRxiv 2025.05.28.655569. Abstract Real-life social interactions often unfold continuously and involve dynamic cooperation and competition, yet most studies rely on discrete games that do not capture
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28.05.2025

Myricetin-bound crystal structure of the SARS-CoV-2 helicase NSP13 facilitates the discovery of novel natural inhibitors

Authors Kloskowski P, Neumann P, Kumar P, Berndt A, Dobbelstein M, Ficner R Journal Acta Crystallographica Section D-Structural Biology Citation Acta Crystallogr D Struct Biol. 2025 Jun 1. Abstract The SARS-CoV-2 helicase NSP13 is a highly conserved and essential component of the viral replication machinery, making it a promising target
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28.05.2025

Structural insights into lipid membrane binding by human ferlins

Authors Cretu C, Chernev A, Szabo CZK, Pena V, Urlaub H, Moser T, Preobraschenski J Journal EMBO Journal Citation EMBO J. 2025 May 28. Abstract Ferlins are ancient membrane proteins with a unique architecture, and play central roles in crucial processes that involve Ca2+-dependent vesicle fusion. Despite their links to
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27.05.2025

Success rates of simulated multi-pulse defibrillation protocols are sensitive to application timing with individual, protocol-specific optimal timings

Authors Aron M, Luther S, Parlitz U Journal Frontiers in Network Physiology Citation Front Netw Physiol. 2025 May 27;5:1572834. Abstract Ventricular fibrillation is a lethal condition where the heartbeat becomes too disorganised to maintain proper circulation. It is treated with defibrillation, which applies an electric shock in an attempt to
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27.05.2025

Toward elucidating the mechanism of cochlear stimulation by infrared light

Authors Moser T, Roos L Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2025 Jun 3;122(22):e2507582122. Abstract No abstract available. DOI 10.1073/pnas.2507582122   Pubmed Link
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22.05.2025

Silencing mitochondrial gene expression in living cells

Authors Cruz-Zaragoza LD, Dahal D, Koschel M, Boshnakovska A, Zheenbekova A, Yilmaz M, Morgenstern M, Dohrke JN, Bender J, Valpadashi A, Henningfeld KA, Oeljeklaus S, Kremer LS, Breuer M, Urbach O, Dennerlein S, Lidschreiber M, Jakobs S, Warscheid B, Rehling P Journal Science Citation Science. 2025 May 22:eadr3498. Abstract Mitochondria
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22.05.2025

Endogenous SNAP-tagging of Munc13-1 for monitoring synapse nanoarchitecture

Authors Kowald M, Bachollet SPJT, Benseler F, Steinecker M, Boll M, Kaushik S, Soykan T, Sun S, Birke R, Ilic D, Brose N, Hörnberg H, Lehmann M, Rizzoli SO, Broichhagen J, Lipstein N Journal JACS Au Citation JACS Au 2025. Abstract Synaptic function is governed by highly regulated protein machineries,
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21.05.2025

SMIM20 promotes complex IV biogenesis and Ca2+ signaling in mice heart

Authors Boshnakovska A, Pronto JR, Gall T, Aich A, Prochazka J, Nichtova Z, Sedlacek R, Sobitov I, Ainatzi S, Lenz C, Katschinski DM, Urlaub H, Voigt N, Rehling P, Kremer LS Journal Cell Reports Citation Cell Reports, Volume 44, Issue 6, 115723. Abstract Mitochondria are key to cellular energetics, metabolism,
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20.05.2025

3D imaging of the human temporal bone by X-ray phase-contrast tomography

Authors Schaeper JJ, Tafforeau P, Kampshoff CA, Thomas C, Meyer A, Stadelmann C, Liberman MC, Moser T, Salditt T Journal npj Imaging Citation npj Imaging 3, 21 (2025). Abstract Studying the subtle and intricate three-dimensional structure of the human cochlea embedded in the temporal bone requires structure-preserving imaging approaches with
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