2024

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11.07.2024

Early mutational signatures and transmissibility of SARS-CoV-2 Gamma and Lambda variants in Chile

Authors Oróstica KY, Mohr SB, Dehning J, Bauer S, Medina-Ortiz D, Iftekhar EN, Mujica K, Covarrubias PC, Ulloa S, Castillo AE, Daza-Sánchez A, Verdugo RA, Fernández J, Olivera-Nappa Á, Priesemann V, Contreras S Journal Scientific Reports Citation Sci Rep. 2024 Jul 11;14(1):16000. Abstract Genomic surveillance (GS) programmes were crucial in
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11.07.2024

Neurofilament Light Chain Serum Levels Mirror Age and Disability in Secondary Progressive Multiple Sclerosis: A Cross-Sectional Study

Authors Husseini L, Jung J, Boess N, Kruse N, Nessler S, Stadelmann C, Metz I, Haupts M, Weber MS Journal Neurology: Neuroimmunology & Neuroinflammation Citation Neurol Neuroimmunol Neuroinflamm. 2024 Sep;11(5):e200279. Abstract Objectives: To assess neurofilament light chain serum (sNfL) levels in patients with secondary progressive multiple sclerosis (SP-MS). Methods: Using
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08.07.2024

Polycystin-1 loss of function increases susceptibility to atrial fibrillation through impaired DNA damage response

Authors Hendrickson T, Giese A, Fiedler M, Perez W, Reyes-Sanchez E, Reyes-Lozano M, Wang S, Venegas-Zamora L, Provasek V, El-Essawi A, Breitenbach I, Fakuade F, Kutschka I, Schiattarella GG, Voigt N, Valderrábano M, Altamirano F Journal BioRxiv Citation bioRxiv 2024.07.08.602618. Abstract Background: The increasing prevalence of atrial fibrillation (AF) and
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05.07.2024

Synthesis and Semi-Synthesis of Alpha-Synuclein: Insight into the Chemical Complexity of Synucleinopathies

Authors Gatzemeier LM, Meyer F, Outeiro TF Journal ChemBioChem Citation Chembiochem. 2024 Jul 5:e202400253. Abstract The chemical rules governing protein folding have intrigued generations of researchers for decades. With the advent of artificial intelligence (AI), prediction of protein structure has improved tremendously. However, there is still a level of analysis
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02.07.2024

Targeting calpain-2-mediated junctophilin-2 cleavage delays heart failure progression following myocardial infarction

Authors Lahiri SK, Lu J, Aguilar-Sanchez Y, Li H, Moreira LM, Hulsurkar MM, Mendoza A, Turkieltaub Paredes MR, Navarro-Garcia JA, Munivez E, Horist B, Moore OM, Weninger G, Brandenburg S, Lenz C, Lehnart SE, Sayeed R, Krasopoulos G, Srivastava V, Zhang L, Karch JM, Reilly S, Wehrens XHT Journal Journal
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02.07.2024

Interfering with aggregated α-synuclein in advanced melanoma leads to a major upregulation of MHC class II proteins

Authors Fokken C, Silbern I, Shomroni O, Pan KT, Ryazanov S, Leonov A, Winkler N, Urlaub H, Griesinger C, Becker D Journal Melanoma Research Citation Melanoma Res. 2024 Jul 2. Abstract Melanoma is the most serious and deadly form of skin cancer and with progression to advanced melanoma, the intrinsically
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29.06.2024

Single-nucleus transcriptomics reveals adrenergic and STAT3 signaling in paradoxical low-flow low-gradient -specific cardiomyocyte subclusters: implications for aortic stenosis pathogenesis and treatment

Authors Xu X, Tan X, Cui B, Paul NB, Elkenani M, Beuthner BE, Li W, Mohamed BA, Schnelle M, Puls M, Zeisberg EM, Zeisberg M, Beißbarth T, Toischer K, Hasenfuß G Journal Cardiovascular Research Citation Cardiovasc Res. 2024 Jun 29:cvae137. Abstract No abstract available. DOI 10.1093/cvr/cvae137   Pubmed Link
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25.06.2024

Structural insights into the regulation of RyR1 by S100A1

Authors Weninger G, Miotto MC, Tchagou C, Reiken S, Dridi H, Brandenburg S, Riedemann GC, Yuan Q, Liu Y, Chang A, Wronska A, Lehnart SE, Marks AR Journal Proceedings of the National Academy of Sciences of the United States of America Citation Proc Natl Acad Sci U S A. 2024
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24.06.2024

Impaired Intracellular Calcium Buffering Contributes to the Arrhythmogenic Substrate in Atrial Myocytes From Patients With Atrial Fibrillation

Authors Fakuade FE, Hubricht D, Möller V, Sobitov I, Liutkute A, Döring Y, Seibertz F, Gerloff M, Pronto JRD, Haghighi F, Brandenburg S, Alhussini K, Ignatyeva N, Bonhoff Y, Kestel S, El-Essawi A, Jebran AF, Großmann M, Danner BC, Baraki H, Schmidt C, Sossalla S, Kutschka I, Bening C, Maack
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22.06.2024

Aging and neurodegeneration: From molecular mechanisms to therapeutic interventions

Authors Outeiro TF, Brocardo PS, Gelain DP Journal Journal of Neurochemistry Citation J Neurochem. 2024 Jun 22. Abstract Protein aggregation is a common age-associated process and can be a pathological hallmark of various neurodegenerative conditions, possibly because of an age-associated decline in the activity of components of the proteostasis network.
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