2022

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06.07.2022

Model-based prediction of optogenetic sound encoding in the human cochlea by future optical cochlear implants

Authors Khurana L, Keppeler D, Jablonski L, Moser T Journal Computational and Structural Biotechnology Journal Citation Comput Struct Biotechn J, 2022. Abstract When hearing fails, electrical cochlear implants (eCIs) partially restore hearing by direct stimulation of spiral ganglion neurons (SGNs). As light can be better confined in space than electrical
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06.07.2022

Single-Molecule Fluorescence Lifetime Imaging Using Wide-Field and Confocal-Laser Scanning Microscopy: A Comparative Analysis

Authors Oleksiievets N, Mathew C, Thiele JC, Gallea J, Nevskyi O, Gregor I, Weber A, Tsukanov R, Enderlein J Journal Nano Letters Citation Nano Lett. 2022. Abstract A recent addition to the toolbox of super-resolution microscopy methods is fluorescence-lifetime single-molecule localization microscopy (FL-SMLM). The synergy of SMLM and fluorescence-lifetime imaging
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05.07.2022

WARS1 and SARS1: two tRNA synthetases implicated in autosomal recessive microcephaly

Authors Bögershausen N, Krawczyk HE, Jamra RA, Lin SJ, Yigit G, Hüning I, Polo AM, Vona B, Huang K, Schmidt J, Altmüller J, Luppe J, Platzer K, Dörgeloh BB, Busche A, Biskup S, Mendes MI, Smith DEC, Salomons GS, Zibat A, Bültmann E, Nürnberg P, Spielmann M, Lemke JR, Li
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05.07.2022

An iodine-containing probe as a tool for molecular detection in secondary ion mass spectrometry

Authors Kabatas Glowacki S, Agüi-Gonzalez P, Sograte-Idrissi S, Jähne S, Opazo F, Phan NTN, Rizzoli SO Journal Chemical Communications Citation Chem. Commun., 2022,58, 7558-7561. Abstract We developed here an iodine-containing probe that can be used to identify the molecules of interest in secondary ion mass spectrometry (SIMS) by simple immunolabelling
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01.07.2022

MemBrain: A deep learning-aided pipeline for detection of membrane proteins in Cryo-electron tomograms

Authors Lamm L, Righetto RD, Wietrzynski W, Pöge M, Martinez-Sanchez A, Peng T, Engel BD Journal Computer Methods and Programs in Biomedicine Citation Comput Methods Programs Biomed. 2022 Jul 1;224:106990. Abstract Background and objective: Cryo-electron tomography (cryo-ET) is an imaging technique that enables 3D visualization of the native cellular environment
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30.06.2022

Distinct roles of the meningeal layers in CNS autoimmunity

Authors Merlini A, Haberl M, Strauß J, Hildebrand L, Genc N, Franz J, Chilov D, Alitalo K, Flügel-Koch C, Stadelmann C, Flügel A, Odoardi F Journal Nature Neuroscience Citation Nat Neurosci. 2022 Jun 30. Abstract The meninges, comprising the leptomeninges (pia and arachnoid layers) and the pachymeninx (dura layer), participate
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27.06.2022

Aromaticity at position 39 in α-synuclein: A modulator of amyloid fibril assembly and membrane-bound conformations

Authors Buratti FA, Boeffinger N, Garro HA, Flores JS, Hita FJ, Gonçalves PDC, Copello FDR, Lizarraga L, Rossetti G, Carloni P, Zweckstetter M, Outeiro TF, Eimer S, Griesinger C, Fernández CO Journal Protein Science Citation Protein Sci. 2022 Jul;31(7):e4360. Abstract Recent studies revealed that molecular events related with the physiology
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22.06.2022

Adventures and Advances in Time Travel With Induced Pluripotent Stem Cells and Automated Patch Clamp

Authors Rosholm KR, Badone B, Karatsiompani S, Nagy D, Seibertz F, Voigt N, Bell DC Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2022 Jun 22;15:898717. Abstract In the Hollywood blockbuster “The Curious Case of Benjamin Button” a fantastical fable unfolds of a man’s life that travels through time
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22.06.2022

Not the classical serendipity: does doxapram treat atrial fibrillation?

Authors Liutkute, A, Brundel BJ, Voigt, N Journal Cardiovascular Research Citation Cardiovasc Res. 2022 Jun 22;118(7):1613-1614. Abstract No abstract available DOI 10.1093/cvr/cvac044   Pubmed Link  
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21.06.2022

Aging-Associated Changes in Cognition, Expression and Epigenetic Regulation of Chondroitin 6-Sulfotransferase Chst3

Authors Baidoe-Ansah D, Sakib S, Jia S, Mirzapourdelavar H, Strackeljan L Fischer A, Aleshin S, Kaushik R, Dityatev A Journal Cells Citation Cells 2022, 11(13), 2033. Abstract Understanding changes in the expression of genes involved in regulating various components of the neural extracellular matrix (ECM) during aging can provide an
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