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19.08.2025

Developmental plasticity facilitates the structural maturation of cochlear inner hair cell ribbon synapses

Authors Voorn RA, Sternbach M, Bourien J, Komiyama N, Rankovic V, Wolf F, Grant SGN, Vogl C Journal BioRxiv Citation bioRxiv 2025.08.19.671016 Abstract Sound detection occurs in the cochlea, where sensory inner hair cells (IHC) accurately convert auditory stimuli into neurochemical signals. Presynaptically, IHCs harbor synaptic ribbons, specialized scaffolds that
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19.08.2025

Proteo-transcriptomic reprogramming and resource reallocation define the aging mammalian brain

Authors Kumar NH, Kluever V, Kaufmann SV, Bergmann C, Mousaei K, Tomas M, Marrero MC, Chopra A, Hirose M, Pallas M, Sanfeliu C, Ibrahim SM, Fischer A, Outeiro TF, Urlaub H, Tchumatchenko T, Lopez Otin C, Fornasiero EF Journal BioRxiv Citation bioRxiv 2025.08.14.669896 Abstract Brain aging is a major risk
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18.08.2025

Introduction to photoswitches and photopharmacology

Authors Cacciarini M, Woolley GA, Szymanski W, Simeth NA Journal Organic & Biomolecular Chemistry Citation Org Biomol Chem. 2025 Aug 18. Abstract No abstract available. DOI 10.1039/d5ob90098k   Pubmed Link  
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18.08.2025

Super-Resolution Axial Imaging for Quantifying Piconewton Traction Forces in Live Cells

Authors Wang DX, Gallea JI, Kong DM, Enderlein J, Chen T Journal Angewandte Chemie (International ed. in Engl.) Citation Angew Chem Int Ed Engl. 2025 Aug 18:e202506864. Abstract Cell mechanics play a pivotal role in regulating numerous biological processes. Although super-resolution microscopy enables the imaging of cellular forces in the
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18.08.2025

Direct mechanical communication of cellular to nuclear shape in oocytes

Authors Vos BE, Vadapalli Y, Muenker TM, Astad Jentoft IM, Todisco E, Eskandari MA, Schuh M, Lenart P, Betz T Journal Biophysical Journal Citation Biophys J. 2025 Aug 18:S0006-3495(25)00524-7. Abstract The mechanical properties of the cytoplasm and nucleoplasm are crucial for the correct and robust functioning of a cell and
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11.08.2025

Chemical crosslinking extends and complements UV crosslinking in analysis of RNA/DNA nucleic acid-protein interaction sites by mass spectrometry

Authors Welp LM, Wulf A, Chernev A, Horokhovskyi Y, Moshkovskii S, Dybkov O, Neumann P, Pašen M, Siraj A, Raabe M, Göthert H, Walshe JL, Infante DA, de A P Schwarzer AC, Dickmanns A, Johannsson S, Schmitzová J, Wohlgemuth I, Netz E, He Y, Fritzemeier K, Delanghe B, Viner R,
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08.08.2025

Update on Gastric Pacemaking: Relevance for Gastroparesis

Authors Riebeling J, Patejdl R, Zipf D, Conradi LC, Ghadimi M, Gundling F, Bruegmann T. Journal Zentralblatt für Chirurgie Citation Zentralbl Chir. 2025 Aug;150(4):337-345. German. Abstract Gastroparesis is a disease in which gastric emptying is significantly decreased in the absence of a mechanical obstruction of the gastric outlet. In addition
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06.08.2025

Microglia-neuron crosstalk via Hex-GM2-MGL2 maintains brain homeostasis

Authors Frosch M, Shimizu T, Wogram E, Amann L, Gruber L, Groisman AI, Fliegauf M, Schwabenland M, Chhatbar C, Zechel S, Rosewich H, Gärtner J, Quintana FJ, Buescher JM, Blank T, Binder H, Stadelmann C, Letzkus JJ, Hopf C, Masuda T, Knobeloch KP, Prinz M Journal Nature Citation Nature. 2025
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02.08.2025

Hierarchically ordered multi-timescale structural dynamics of the intrinsically disordered p53 transactivation domain

Authors Szöllősi D, Pratihar S, Mukhopadhyay D, Rout AK, Reddy GJ, Ebersberger N, Becker S, Nagy G, Rauscher S, Lee D, Klement R, Griesinger C, Grubmüller H Journal BioRxiv Citation bioRxiv 2025.08.01.668138 Abstract Intrinsically disordered proteins (IDPs) exhibit pronounced structural dynamics, which is crucial for their functional versatility. Yet their
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01.08.2025

Local Poisson Deconvolution for Discrete Signals

Authors Hundrieser S, Manole T, Litskevich D, Munk A Journal Arxiv Citation arXiv:2508.00824. Abstract We analyze the statistical problem of recovering an atomic signal, modeled as a discrete uniform distribution μ, from a binned Poisson convolution model. This question is motivated, among others, by super-resolution laser microscopy applications, where precise
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