Latest Publications

Authors Flores-León M, Outeiro TF Journal Movement Disorders Citation Mov Disord. 2025 Dec 26. Abstract Neurodegenerative diseases are pathological states characterized by progressive alterations in brain homeostasis during aging. Synucleinopathies, including Parkinson’s disease and dementia with Lewy bodies, are defined neuropathologically by the accumulation of inclusions known as Lewy bodies

Authors Landt C, Held F, Kolotourou K, Guranda M, Vakrakou AG, Franz J, Thomas C, Schmiedeknecht MUH, Bergann K, Wrzos C, Endmayr V, Tsaktanis T, Zechel S, Ancău M, Misgeld T, Hakroush S, Hametner S, Rothhammer V, Höftberger R, Hemmer B, Stadelmann C, Nessler S Journal Neurology: Neuroimmunology and Neuroinflammation

Authors Dvoretskii S, Archit A, Pape C, Moore J, Nolden M Journal Arxiv Citation arXiv:2512.15820. Abstract Modern bioimage analysis approaches are data hungry, making it necessary for researchers to scavenge data beyond those collected within their (bio)imaging facilities. In addition to scale, bioimaging datasets must be accompanied with suitable, high-quality

Authors Basak S, Inamdar K, Pollack YG, Albert L, Jans DC, Jakobs S, Enderlein J, Tsukanov R, Opazo F Journal BioRxiv Citation bioRxiv 2025.12.17.694880 Abstract Direct STORM relies on robust fluorophore blinking; observations suggest that AlexaFluor647 underperforms when coupled to nanobodies, thereby undermining the advantages of nanobodies. We show that

Authors Archit A, Freckmann L, Pape C Journal IEEE Transactions on Medical Imaging Citation IEEE Trans Med Imaging. 2025 Dec 17;PP. Abstract Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models

Authors Svennberg E, Merino JL, Andrade J, Anselmino M, Arbelo E, Boersma E, Boriani G, Breithardt G, Chung M, Chyou J, Cohen A, Nielsen JC, Dichtl W, Diederichsen SZ, Dobrev D, Doehner W, Dworatzek E, Fabritz L, Filgueiras-Rama D, Gimpelewitz C, Hack G, Hatem S, Healey J, Heidbuchel H, Hijazi

Authors Müller L, Sartori F, Dehning J, Eggl MF, Priesemann V Journal Arxiv Citation arXiv:2512.11454. Abstract Mitigation measures are essential for controlling the spread of infectious diseases during pandemics and epidemics, but they impose considerable societal, individual, and economic costs. We developed a general optimization framework to balance costs related

Authors Suchan L, Li H, Munk A Journal Electronic Journal of Statistics Citation Electron. J. Statist. 19(2): 5925-5978 (2025). Abstract Graph cuts are among the most prominent tools for clustering and classification analysis. While intensively studied from geometric and algorithmic perspectives, graph cut-based statistical inference still remains elusive to a

Authors Enderlein J Journal eLight Citation eLight 5, 34 (2025). Abstract Historically constrained by the low throughput of traditional Time-Correlated Single-Photon Counting (TCSPC), a new method utilizes an optimized, time-gated single-photon camera acquisition scheme for achieving single-molecule lifetime precision comparable to TCSPC, but across a wide field of view simultaneously.

Authors Roos L, Garrido-Charles A, Albrecht N, Vavakou A, Alekseev A, Bleyer M, Thirumalai A, Mittring A, Alvanos T, Huet AT, Bamberg E, Kusch K, Wolf BJ, Moser T, Mager T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2025 Dec 9. Abstract Optogenetics allows versatile control of excitable cell