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13.12.2019

The small molecule inhibitor anle145c thermodynamically traps human islet amyloid peptide in the form of non-cytotoxic oligomers

Authors Saravanan MS, Ryazanov S, Leonov A, Nicolai J, Praest P, Giese A, Winter R, Khemtemourian L, Griesinger C, Killian JA Journal Scientific Reports Citation Sci Rep. 2019 Dec 13;9(1):19023. Abstract Type 2 diabetes (T2DM) is associated with aggregation of the human islet amyloid polypeptide (hIAPP) into cytotoxic amyloid species.
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27.08.2019

Live-cell STED nanoscopy of mitochondrial cristae

Authors Stephan T, Roesch A, Riedel D, Jakobs S Journal Scientific Reports Citation Sci Rep. 2019 Aug 27;9(1):12419. Abstract Mitochondria are highly dynamic organelles that exhibit a complex inner architecture. They exhibit a smooth outer membrane and a highly convoluted inner membrane that forms invaginations called cristae. Imaging cristae in
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04.02.2019

High-resolution experimental and computational electrophysiology reveals weak beta-lactam binding events in the porin PorB

Authors Bartsch A, Llabres S, Pein F, Kattner C, Schon M, Diehn M, Tanabe M, Munk A, Zachariae U, Steinem C Journal Scientific Reports Citation Sci Rep. 2019 Feb 4;9(1):1264. Abstract The permeation of most antibiotics through the outer membrane of Gram-negative bacteria occurs through porin channels. To design drugs
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15.11.2018

The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain

Authors Mandad S, Rahman RU, Centeno TP, Vidal RO, Wildhagen H, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Kirli K, Benito E, Fischer A, Yousefi RY, Dennerlein S, Rehling P, Feussner I, Urlaub H, Bonn S, Rizzoli SO, Fornasiero EF Journal Scientific Reports Citation Sci Rep. 2018
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