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Generation of bright autobioluminescent bacteria by chromosomal integration of the improved lux operon ilux2

Authors Gregor C Journal Scientific Reports Citation Sci Rep. 2022 Nov 9;12(1):19039. Abstract The bacterial bioluminescence system enables the generation of light by living cells without the requirement of an external luciferin. Due to the relatively low light emission, many applications of bioluminescence imaging would benefit from an increase in
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Simultaneous assessment of lung morphology and respiratory motion in retrospectively gated in-vivo microCT of free breathing anesthetized mice

Authors Dullin C, Svetlove A, Zschüntzsch J, Alves F Journal Scientific Reports Citation Sci Rep. 2022 Aug 2;12(1):13299. Abstract Retrospective gating (RG) is a well established technique in preclinical computed tomography (CT) to assess 3D morphology of the lung. In RG additional angular projections are recorded typically by performing multiple
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Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes

Authors Weninger G, Pochechueva T, El Chami D, Luo X, Kohl T, Brandenburg S, Urlaub H, Guan K, Lenz C, Lehnart SE Journal Science Reports Citation Sci Rep. 2022 Jun 20;12(1):10387. Abstract Calpains are calcium-activated neutral proteases involved in the regulation of key signaling pathways. Junctophilin-2 (JP2) is a Calpain-specific
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A novel single-cell RNA-sequencing approach and its applicability connecting genotype to phenotype in ageing disease

Authors Shomroni O, Sitte M, Schmidt J, Parbin S, Ludewig F, Yigit G, Zelarayan LC, Streckfuss-Bömeke K, Wollnik B, Salinas G Journal Scientific Reports Citation Sci Rep. 2022 Mar 8;12(1):4091. Abstract Single cell multi-omics analysis has the potential to yield a comprehensive understanding of the cellular events that underlie the
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Monitoring the interactions between alpha-synuclein and Tau in vitro and in vivo using bimolecular fluorescence complementation

Authors Torres-Garcia L, P Domingues JM, Brandi E, Haikal C, Mudannayake JM, Brás IC, Gerhardt E, Li W, Svanbergsson A, Outeiro TF, Gouras GK, Li JY Journal Science Reports Citation Sci Rep 12, 2987 (2022). Abstract Parkinson’s disease (PD) and Alzheimer’s disease (AD) are characterized by pathological accumulation and aggregation of different
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Proteomic mapping of atrial and ventricular heart tissue in patients with aortic valve stenosis

Authors Barbarics B, Eildermann K, Kaderali L, Cyganek L, Plessmann U, Bodemeyer J, Paul T, Ströbel P, Urlaub H, Tirilomis T, Lenz C, Bohnenberger H. Journal Scientific Reports Citation Sci Rep. 2021 Dec 22;11(1):24389. Abstract Aortic valve stenosis (AVS) is one of the most common valve diseases in the world.
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Differences in synaptic vesicle pool behavior between male and female hippocampal cultured neurons

Authors Sertel SM, Blumenstein W, Mandad S, Shomroni O, Salinas G, Rizzoli SO Journal Scientific Reports Citation Sci Rep. 2021 Aug 30;11(1):17374. Abstract A strong focus on sex-related differences has arisen recently in neurobiology, but most investigations focus on brain function in vivo, ignoring common experimental models like cultured neurons.
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A minimalist model to measure interactions between proteins and synaptic vesicles

Authors Perego E, Reshetniak S, Lorenz C, Hoffmann C, Milovanovic D, Rizzoli S, Köster S Journal Scientific Reports Citation Sci Rep 10, 21086 (2020). Abstract Protein dynamics in the synaptic bouton are still not well understood, despite many quantitative studies of synaptic structure and function. The complexity of the synaptic
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X-ray diffraction and second harmonic imaging reveal new insights into structural alterations caused by pressure-overload in murine hearts

Authors Nicolas JD, Khan A, Markus A, Mohamed BA, Toischer K, Alves F, Salditt T Journal Scientific Reports Citation Sci Rep. 2020 Nov 9;10(1):19317. Abstract We demonstrate a label-free imaging approach to study cardiac remodeling of fibrotic and hypertrophic hearts, bridging scales from the whole organ down to the molecular
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Effects of pharmacological modulators of α‐synuclein and tau aggregation and internalization

Authors Dominguez-Meijide A, Vasili E, König A, Cima-Omori MS, Ibáñez de Opakua A, Leonov A, Ryazanov S, Zweckstetter M, Griesinger C, Outeiro TF Journal Scientific Reports Citation Sci Rep 10, 12827 (2020). Abstract Parkinson’s disease (PD) and Alzheimer’s disease (AD) are common neurodegenerative disorders of the elderly and, therefore, affect
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