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20.04.2026

Labeling and imaging of neurons with a genetically encoded autonomous bioluminescence system

Authors Brinker T, Günther A, Kiszka KA, Rhee JS, Gregor C Journal Scientific Reports Citation Sci Rep. 2026 Apr 20;16(1):12892. Abstract The bacterial bioluminescence system, consisting of a luciferase and enzymes for intracellular luciferin synthesis, enables autonomous bioluminescence imaging of mammalian cells. Its continuous light emission without the need for
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26.03.2026

Dysferlin stabilizes membrane nanodomains of cardiomyocytes after myocardial infarction

Authors Wegener JB, Zühlke Y, Fleischhacker C, Marks J, Foo B, Bader N, Riedemann GC, Wedemeyer J, Vu KC, Vergel Leon AM, Paulke NJ, Kohl T, Urlaub H, Schmidt C, Hasenfuß G, Moser T, Rog-Zielinska EA, Lenz C, Lehnart SE, Brandenburg S Journal Scientific Reports Citation Sci Rep. 2026 Mar
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23.03.2026

Persistence of vestibular function in the absence of glutamatergic transmission from hair cells

Authors Mukhopadhyay M, Modgekar R, Yang-Hood A, Ohlemiller KK, Militchin V, Xiao M, Shen Z, Rensing NR, Wong M, Lee SJ, Seal RP, Holt JC, Warchol ME, Maloney SE, Yuede CM, Rutherford MA, Pangrsic T Journal Scientific Reports Citation Sci Rep. 2026 Mar 23. Abstract Quantal synaptic transmission in vestibular
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24.03.2025

PHluorin-conjugated secondary nanobodies as a tool for measuring synaptic vesicle exo- and endocytosis

Authors Georgiev SV, Rizzoli SO Journal Scientific Reports Citation Sci Rep 15, 10093 (2025). Abstract Neuronal communication relies on synaptic vesicle recycling, which has long been investigated by live imaging approaches. Synapto-pHluorins, genetically encoded reporters that incorporate a pH-sensitive variant of GFP within the lumen of the synaptic vesicle, have
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07.03.2025

3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography

Authors Schaeper JJ, Kampshoff CA, Wolf BJ, Roos L, Michanski S, Ruhwedel T, Eckermann M, Meyer A, Jeschke M, Wichmann C, Moser T, Salditt T Journal Scientific Reports Citation Sci Rep. 2025 Mar 7;15(1):7933. Abstract Multi-scale X-ray phase contrast tomography (XPCT) enables three-dimensional (3D), non-destructive imaging of intact small animal
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22.01.2025

Three-dimensional structure of entire hydrated murine hearts at histological resolution

Authors Frohn J, Böddeker F, Reichardt M, Bruns H, Czajka T, Khan A, Broche L, Krisch M, Bravin A, Alves F, Zschüntzsch J, Salditt T Journal Scientific Reports Citation Sci Rep. 2025 Jan 22;15(1):2766. Abstract Imaging the entire cardiomyocyte network in entire small animal hearts at single cell resolution is
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11.07.2024

Early mutational signatures and transmissibility of SARS-CoV-2 Gamma and Lambda variants in Chile

Authors Oróstica KY, Mohr SB, Dehning J, Bauer S, Medina-Ortiz D, Iftekhar EN, Mujica K, Covarrubias PC, Ulloa S, Castillo AE, Daza-Sánchez A, Verdugo RA, Fernández J, Olivera-Nappa Á, Priesemann V, Contreras S Journal Scientific Reports Citation Sci Rep. 2024 Jul 11;14(1):16000. Abstract Genomic surveillance (GS) programmes were crucial in
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29.05.2024

3D imaging of SARS-CoV-2 infected hamster lungs by X-ray phase contrast tomography enables drug testing

Authors Reichmann J, Sarrazin C, Schmale S, Blaurock C, Balkema-Buschmann A, Schmitzer B, Salditt T Journal Scientific Reports Citation Sci Rep 14, 12348 (2024). Abstract X-ray Phase Contrast Tomography (XPCT) based on wavefield propagation has been established as a high resolution three-dimensional (3D) imaging modality, suitable to reconstruct the intricate
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29.03.2024

Label-free quantification of imaging features in the extracellular matrix of left and right-sided colon cancer tissues

Authors Arora B, Kulkarni A, Markus MA, Ströbel P, Bohnenberger H, Alves F, Ramos-Gomes F Journal Scientific Reports Citation Sci Rep. 2024 Mar 29;14(1):7510. Abstract The molecular pathogenesis of colorectal cancer is known to differ between the right and left side of the colon. Several previous studies have focussed on
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21.12.2023

Visualization of deglutition and gastroesophageal reflux using real-time MRI: a standardized approach to image acquisition and assessment

Authors Biggemann L, Uhlig J, Streit U, Al-Bourini O, Wedi E, Amanzada A, Ellenrieder V, Rühlmann F, Ghadimi M, Frahm J, Uecker M, Seif Amir Hosseini A Journal Science Reports Citation Sci Rep. 2023 Dec 21;13(1):22854. Abstract This study aims to develop a standardized algorithm for gastroesophageal image acquisition and
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