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22.06.2020

MICOS assembly controls mitochondrial inner membrane remodeling and crista junction redistribution to mediate cristae formation

Authors Stephan T, Bruser C, Deckers M, Steyer M, Balzarotti F, Barbot M, Behr TS, Heim G, Hubner W, Ilgen P, Lange F, Pacheu-Grau D, Pape JK, Stoldt S, Huser T, Hell SW, Möbius W, Rehling P, Riedel D, Jakobs S Journal EMBO Journal Citation EMBO J 2020 Jun 22;e104105
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22.06.2020

Real-time cardiovascular magnetic resonance T1 and extracellular volume fraction mapping for tissue characterisation in aortic stenosis

Authors Backhaus SJ, Lange T, Beuthner BE, Topci R, Wang X, Kowallick JT, Lotz J, Seidler T, Toischer K, Zeisberg EM, Puls M, Jacobshagen C, Uecker M, Hasenfuß G, Schuster A Journal Journal of Cardiovascular Magnetic Resonance Citation J Cardiovasc Magn Reson. 2020;22(1):46. Published 2020 Jun 22. Abstract Background: Myocardial
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16.06.2020

Nucleosome-CHD4 chromatin remodeler structure maps human disease mutations

Authors Farnung L, Ochmann M, Cramer P Journal Elife Citation Elife. 2020;9:e56178. Published 2020 Jun 16. Abstract Chromatin remodeling plays important roles in gene regulation during development, differentiation and in disease. The chromatin remodeling enzyme CHD4 is a component of the NuRD and ChAHP complexes that are involved in gene
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16.06.2020

Large field-of-view scanning small-angle X-ray scattering of mammalian cells

Authors Cassini C, Wittmeier A, Brehm G, Denz M, Burghammer M, Köster S Journal Journal of Synchrotron Radiation Citation J. Synchrotron Rad. (2020). 27, 1059–1068. Abstract X-ray imaging is a complementary method to electron and fluorescence microscopy for studying biological cells. In particular, scanning small-angle X-ray scattering provides overview images of whole cells
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15.06.2020

Structure of complete Pol II-DSIF-PAF-SPT6 transcription complex reveals RTF1 allosteric activation

Authors Vos SM, Farnung L, Linden A, Urlaub H, Cramer P Journal Nature Structural & Molecular Biology Citation Nat Struct Mol Biol. 2020. Abstract Transcription by RNA polymerase II (Pol II) is carried out by an elongation complex. We previously reported an activated porcine Pol II elongation complex, EC*, encompassing
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08.06.2020

Bi-allelic Missense Disease-Causing Variants in RPL3L Associate Neonatal Dilated Cardiomyopathy With Muscle-Specific Ribosome Biogenesis

Authors Ganapathi M, Argyriou L, Martínez-Azorín F,  Morlot S, Yigit G, Lee TM,  Auber B, von Gise A, Petrey DS, Thiele H, Cyganek L, Sabater-Molina M, Ahimaz P, Cabezas-Herrera J, Sorlí-García M, Zibat A, Siegelin MD, Burfeind P, Buchovecky CM, Hasenfuss G, Honig B, Li Y, Iglesias AD, Wollnik B Journal Human Genetics Citation Hum Genet. 2020 Jun 8. Online ahead of print. Abstract Dilated cardiomyopathy (DCM) belongs to the most frequent forms of cardiomyopathy mainly characterized by
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08.06.2020

CTCF is dispensable for immune cell transdifferentiation but facilitates an acute inflammatory response

Authors Stik G, Vidal E, Barrero M, Cuartero S, Vila-Casadesús M, Mendieta-Esteban J, Tian TV, Choi J, Berenguer C, Abad A, Borsari B, le Dily F, Cramer P, Marti-Renom MA, Stadhouders R, Graf T Journal Nature Genetics Citation Nat Genet. 2020 Jul;52(7):655-661. Abstract Three-dimensional organization of the genome is important
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05.06.2020

Fluorescence polarization filtering for accurate single molecule localization

Authors Nevskyi O, Tsukanov R, Gregor I, Karedla N, Enderlein J Journal APL Photonics Citation APL Photonics 5, 061302 (2020). Abstract Single-Molecule Localization Microscopy (SMLM) has become one of the most important methods of super-resolution fluorescencemicroscopy. It is based on the precise localization of single molecules in wide-field microscopy images.
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03.06.2020

Generation of Engineered Human Myocardium in a Multi-well Format

Authors Tiburcy M, Meyer T, Liaw NY, Zimmermann WH Journal STAR protocols Citation STAR Protoc. 2020 Jun 3;1(1):100032. Abstract This protocol describes a robust method for the generation of engineered human myocardium (EHM) from pluripotent stem cells (PSCs) in a multi-well plate under defined, serum-free conditions. By parallel culture of
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02.06.2020

Empirical regularized optimal transport: Statistical theory and applications

Authors Klatt M, Tameling C, Munk A Journal SIAM Journal on Mathematics of Data Science Citation SIAM Journal on Mathematics of Data Science 2 (2), 419-443. Abstract We derive limit distributions for various empirical regularized optimal transport quantities between probability distributions supported on a finite metric space and show their
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