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15.11.2024

Trials and tribulations of cell therapy for heart failure: an update on ongoing trials

Authors Zhang JJ, Pogwizd SM, Fukuda K, Zimmermann WH, Fan C, Hare JM, Bolli R, Menasché P Journal Nature Reviews. Cardiology Citation Nat Rev Cardiol. 2024 Nov 15. Abstract Heart failure (HF) remains a leading cause of mortality, responsible for 13% of all deaths worldwide. The prognosis for patients with
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06.11.2024

α-Synuclein plastic antibody applied to monitor monomeric structures and discriminate aggregated forms in human CSF

Authors da Silva IS, Cardoso AR, Reimer L, König A, van Riesen C, Outeiro TF, Jensen PH, Sales MGF Journal Biosensors and Bioelectronics Citation Biosensors and Bioelectronics 268 (2025) 116880. Abstract Aggregation of alpha-synuclein (aSyn) occurs in presynaptic neurons and constitutes a key factor for the progression of Parkinson’s disease,
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01.11.2024

A Unifying Approach to Distributional Limits for Empirical Optimal Transport

Authors Hundrieser S, Klatt M, Munk A, Staudt T Journal Bernoulli Citation Bernoulli 30 (4), 2846-2877. Abstract We provide a unifying approach to central limit type theorems for empirical optimal transport (OT). The limit distribution is given by a supremum of a centered Gaussian process, and we explicitly characterize when it
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30.10.2024

Identifiability of the Optimal Transport Cost on Finite Spaces

Authors Gonualez-Sanz A, Groppe M, Munk A Journal Arxiv Citation arXiv:2410.23146. Abstract The goal of optimal transport (OT) is to find optimal assignments or matchings between data sets which minimize the total cost for a given cost function. However, sometimes the cost function is unknown but we have access to
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30.10.2024

Stress Vulnerability Exposed by Mapping Brain Network States to Single-Cell Transcriptomes

Authors Fischer A, Radulovic J Journal Biological Psychiatry Citation Biol Psychiatry. 2024 Dec 1;96(11):832-834. Abstract No abstract available. DOI 10.1016/j.biopsych.2024.08.024   Pubmed Link
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27.10.2024

Impact of Phosphorylation on the Physiological Form of Human alpha-Synuclein in Aqueous Solution

Authors de Bruyn E, Dorn AE, Rossetti G, Fernandez C, Outeiro TF, Schulz JB, Carloni P Journal Journal of Chemical Information and Modeling Citation J Chem Inf Model. 2024 Oct 27. Abstract Serine 129 can be phosphorylated in pathological inclusions formed by the intrinsically disordered protein human α-synuclein (AS), a
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25.10.2024

Increased autonomous bioluminescence emission from mammalian cells by enhanced cofactor synthesis

Authors Brinker T, Gregor C Journal Chemosensors Citation Chemosensors 2024, 12, 223. Abstract The bacterial bioluminescence system has been successfully implemented in mammalian cell lines, enabling the substrate-free luminescence imaging of living cells. One of the major limitations of the system is its comparatively low brightness. To improve light emission,
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24.10.2024

Unbiased complexome profiling and global proteomics analysis reveals mitochondrial impairment and potential changes at the intercalated disk in presymptomatic R14Δ/+ mice hearts

Authors Foo B, Amedei H, Kaur S, Jaawan S, Boshnakovska A, Gall T, de Boer RA, Silljé HHW, Urlaub H, Rehling P, Lenz C, Lehnart SE Journal PLoS One Citation PLoS One. 2024 Oct 24;19(10):e0311203. Abstract Phospholamban (PLN) is a sarco-endoplasmic reticulum (SER) membrane protein that regulates cardiac contraction/relaxation by
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21.10.2024

Multiscale scanning with nuisance parameters

Authors König C, Munk A, Werner F Journal Journal of the Royal Statistical Society Series B: Statistical Methodology Citation J R Stat Soc Series B: Statistical Methodology, 2024, 00, 1–19. Abstract We develop a multiscale scanning method to find anomalies in a d-dimensional random field in the presence of nuisance
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21.10.2024

Changes in DNA repair compartments and cohesin loss promote DNA damage accumulation in aged oocytes

Authors Sharma N, Coticchio G, Borini A, Tachibana K, Nasmyth KA, Schuh M Journal Current Biology Citation Curr Biol. 2024 Oct 17:S0960-9822(24)01281-8. Abstract Oocyte loss, a natural process that accelerates as women approach their mid-30s, poses a significant challenge to female reproduction. Recent studies have identified DNA damage as a
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