Authors
Kiszka KA, Dullin C, Steffens H, Koenen T, Rothermel E, Alves F, Gregor C
Journal
Science Advances
Citation
Sci Adv. 2025 Jul 11;11(28):eads0463.
Abstract
The bacterial bioluminescence system can be applied to produce autonomous bioluminescence in mammalian cells. Until now, the system has only been stably inserted into cells cultured in vitro. Here, we report the generation of an autobioluminescent transgenic mouse line constitutively expressing the genes of the bacterial bioluminescence system, enabling substrate-free in vivo luminescence imaging of a living mammal.
