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15.02.2022

Statistical spatial analysis for cryo-electron tomography

Authors Martinez-Sanchez A, Baumeister W, Lučić V Journal Computer Methods and Programs in Biomedicine Citation Comput Methods Programs Biomed. 2022 Feb 15;218:106693.  Abstract Cryo-electron tomography (cryo-ET) is uniquely suited to precisely localize macromolecular complexes in situ, that is in a close-to-native state within their cellular compartments, in three-dimensions at high resolution.
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11.02.2022

Role of Mitochondrial Nucleic Acid Sensing Pathways in Health and Patho-Physiology

Authors Chowdhury A, Witte S, Aich A Journal Frontiers in Cell and Developmental Biology Citation Front Cell Dev Biol. 2022 Feb 11;10:796066.  Abstract Mitochondria, in symbiosis with the host cell, carry out a wide variety of functions from generating energy, regulating the metabolic processes, cell death to inflammation. The most prominent
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11.02.2022

Allosteric control of Ubp6 and the proteasome via a bidirectional switch

Authors Hung KYS, Klumpe S, Eisele MR, Elsasser S, Tian G, Sun S, Moroco JA, Cheng TC, Joshi T, Seibel T, Van Dalen D, Feng XH, Lu Y, Ovaa H, Engen JR, Lee BH, Rudack T, Sakata E, Finley D Journal Nature Communications Citation Nat Commun. 2022 Feb 11;13(1):838. Abstract
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11.02.2022

Mechanism of spindle pole organization and instability in human oocytes

Authors So C, Menelaou K, Uraji J, Harasimov K, Steyer AM, Seres KB, Bucevičius J, Lukinavičius G, Möbius W, Sibold C, Tandler-Schneider A, Eckel H, Moltrecht R, Blayney M, Elder K, Schuh M Journal Science Citation Science. 2022 Feb 11;375(6581):eabj3944. Abstract Human oocytes are prone to assembling meiotic spindles with
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10.02.2022

Rethinking opsins

Authors Feuda R, Menon AK, Göpfert MC Journal Molecular Biology and Evolution Citation Mol Biol Evol. 2022 Feb 10:msac033. Abstract Opsins, the protein moieties of animal visual photo-pigments, have emerged as moonlighting proteins with diverse, light-dependent and -independent physiological functions. This raises the need to revise some basic assumptions concerning
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31.01.2022

Single-cell transcription profiles in Bloom syndrome patients link BLM deficiency with altered condensin complex expression signatures

Authors Gönenc II, Wolff A, Schmidt J, Zibat A, Müller C, Cyganek L, Argyriou L, Räschle M, Yigit G, Wollnik B Journal Human Molecular Genetics Citation Hum Mol Genet. 2022 Jan 31:ddab373. Abstract Bloom syndrome (BS) is an autosomal recessive disease clinically characterized by primary microcephaly, growth deficiency, immunodeficiency, and
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27.01.2022

Structural basis for safe and efficient energy conversion in a respiratory supercomplex

Authors Kao WC, Ortmann de Percin Northumberland C, Cheng TC, Ortiz J, Durand A, von Loeffelholz O, Schilling O, Biniossek ML, Klaholz BP, Hunte C Journal Nature Communications Citation Nat Commun. 2022 Jan 27;13(1):545. Abstract Proton-translocating respiratory complexes assemble into supercomplexes that are proposed to increase the efficiency of energy
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27.01.2022

A Molecular Pump Facilitates Mechanical Adsorption Away from Equilibrium

Authors Simeth NA Journal Angewandte Chemie (International Edition) Citation Angew Chem Int Ed Engl. 2022 Jan 27:e202115145. Abstract Artificial molecular pumps that perform unidirectional motion on the molecular scale have been used to design systems operating away from equilibrium. Crafting such pumps onto a surface allows their unidirectional movement to
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26.01.2022

Ovarian carcinoma immunoreactive antigen-like protein 2 (OCIAD2) is a novel complex III specific assembly factor in mitochondria

Authors Chojnacka KJ, Elancheliyan P, Mussulini BHM, Mohanraj K, Callegari S, Gosk A, Banach T, Góral T, Szczepanowska K, Rehling P, Serwa RA, Chacińska A Journal Molecular Biology of the Cell Citation Mol Biol Cell. 2022 Jan 26:mbcE21030143. Abstract Assembly of the dimeric complex III (CIII2) in the mitochondrial inner
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26.01.2022

Real-time radial tagging for quantification of left ventricular torsion

Authors Mohammadi E, Nasiraei-Moghaddam A, Uecker M Journal Magnetic Resonance in Medicine Citation Magn Reson Med. 2022 Jan 26. Abstract Purpose: To develop a real-time radial tagging MRI for accurate measurement of rotational motion and twist of the left ventricle (LV). Methods: A FLASH-based radial tagging sequence with an undersampled
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