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05.07.2022

An iodine-containing probe as a tool for molecular detection in secondary ion mass spectrometry

Authors Kabatas Glowacki S, Agüi-Gonzalez P, Sograte-Idrissi S, Jähne S, Opazo F, Phan NTN, Rizzoli SO Journal Chemical Communications Citation Chem. Commun., 2022,58, 7558-7561. Abstract We developed here an iodine-containing probe that can be used to identify the molecules of interest in secondary ion mass spectrometry (SIMS) by simple immunolabelling
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01.07.2022

MemBrain: A deep learning-aided pipeline for detection of membrane proteins in Cryo-electron tomograms

Authors Lamm L, Righetto RD, Wietrzynski W, Pöge M, Martinez-Sanchez A, Peng T, Engel BD Journal Computer Methods and Programs in Biomedicine Citation Comput Methods Programs Biomed. 2022 Jul 1;224:106990. Abstract Background and objective: Cryo-electron tomography (cryo-ET) is an imaging technique that enables 3D visualization of the native cellular environment
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30.06.2022

Distinct roles of the meningeal layers in CNS autoimmunity

Authors Merlini A, Haberl M, Strauß J, Hildebrand L, Genc N, Franz J, Chilov D, Alitalo K, Flügel-Koch C, Stadelmann C, Flügel A, Odoardi F Journal Nature Neuroscience Citation Nat Neurosci. 2022 Jun 30. Abstract The meninges, comprising the leptomeninges (pia and arachnoid layers) and the pachymeninx (dura layer), participate
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27.06.2022

Aromaticity at position 39 in α-synuclein: A modulator of amyloid fibril assembly and membrane-bound conformations

Authors Buratti FA, Boeffinger N, Garro HA, Flores JS, Hita FJ, Gonçalves PDC, Copello FDR, Lizarraga L, Rossetti G, Carloni P, Zweckstetter M, Outeiro TF, Eimer S, Griesinger C, Fernández CO Journal Protein Science Citation Protein Sci. 2022 Jul;31(7):e4360. Abstract Recent studies revealed that molecular events related with the physiology
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22.06.2022

Adventures and Advances in Time Travel With Induced Pluripotent Stem Cells and Automated Patch Clamp

Authors Rosholm KR, Badone B, Karatsiompani S, Nagy D, Seibertz F, Voigt N, Bell DC Journal Frontiers in Molecular Neuroscience Citation Front Mol Neurosci. 2022 Jun 22;15:898717. Abstract In the Hollywood blockbuster “The Curious Case of Benjamin Button” a fantastical fable unfolds of a man’s life that travels through time
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22.06.2022

Not the classical serendipity: does doxapram treat atrial fibrillation?

Authors Liutkute, A, Brundel BJ, Voigt, N Journal Cardiovascular Research Citation Cardiovasc Res. 2022 Jun 22;118(7):1613-1614. Abstract No abstract available DOI 10.1093/cvr/cvac044   Pubmed Link  
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21.06.2022

Aging-Associated Changes in Cognition, Expression and Epigenetic Regulation of Chondroitin 6-Sulfotransferase Chst3

Authors Baidoe-Ansah D, Sakib S, Jia S, Mirzapourdelavar H, Strackeljan L Fischer A, Aleshin S, Kaushik R, Dityatev A Journal Cells Citation Cells 2022, 11(13), 2033. Abstract Understanding changes in the expression of genes involved in regulating various components of the neural extracellular matrix (ECM) during aging can provide an
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20.06.2022

Calpain cleavage of Junctophilin-2 generates a spectrum of calcium-dependent cleavage products and DNA-rich NT1-fragment domains in cardiomyocytes

Authors Weninger G, Pochechueva T, El Chami D, Luo X, Kohl T, Brandenburg S, Urlaub H, Guan K, Lenz C, Lehnart SE Journal Science Reports Citation Sci Rep. 2022 Jun 20;12(1):10387. Abstract Calpains are calcium-activated neutral proteases involved in the regulation of key signaling pathways. Junctophilin-2 (JP2) is a Calpain-specific
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18.06.2022

Structural and mechanistic basis of RNA processing by protein-only ribonuclease P enzymes

Authors Bhatta A, Hillen HS Journal Trends in Biochemical Sciences Citation Trends Biochem Sci. 2022 Jun 18:S0968-0004(22)00139-6. Abstract Ribonuclease P (RNase P) enzymes are responsible for the 5′ processing of tRNA precursors. In addition to the well-characterised ribozyme-based RNase P enzymes, an evolutionarily distinct group of protein-only RNase Ps exists.
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15.06.2022

Extracellular alpha-synuclein: Sensors, receptors, and responses

Authors Domingues R, Sant’Anna R, da Fonseca ACC, Robbs BK, Foguel D, Outeiro TF Journal Neurobiology of Disease Citation Neurobiol Dis. 2022 Jun 15;168:105696. Abstract Synucleinopathies are a group of progressive neurodegenerative diseases known for the accumulation of insoluble aggregates containing the protein alpha-synuclein (aSyn). Recently, it has been assumed
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