International Journal of Molecular Sciences

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10.03.2024

3D Super-Resolution Nuclear Q-FISH Imaging Reveals Cell-Cycle-Related Telomere Changes

Authors Pochechueva TV, Schwenzer N, Kohl T, Brandenburg S, Kaltenecker G, Wollnik B, Lehnart SE Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2024 Mar 10;25(6):3183. Abstract We present novel workflows for Q-FISH nanoscopy with the potential for prognostic applications and resolving novel chromatin compaction changes. DNA-fluorescence
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09.09.2023

An Animal Model for Chronic Meningeal Inflammation and Inflammatory Demyelination of the Cerebral Cortex

Authors Enz LS, Winkler A, Wrzos C, Dasen B, Nessler S, Stadelmann C, Schaeren-Wiemers N Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2023 Sep 9;24(18):13893. Abstract Modeling chronic cortical demyelination allows the study of long-lasting pathological changes observed in multiple sclerosis such as failure of remyelination,
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30.08.2023

Changes in α-Synuclein Posttranslational Modifications in an AAV-Based Mouse Model of Parkinson’s Disease

Authors Brembati V, Faustini G, Longhena F, Outeiro TF, Bellucci A Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2023, 24(17) Abstract Parkinson’s disease (PD) pathology is characterized by the loss of dopaminergic neurons of the nigrostriatal system and accumulation of Lewy bodies (LB) and Lewy neurites
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09.08.2023

Beyond Motor Deficits: Environmental Enrichment Mitigates Huntington’s Disease Effects in YAC128 Mice

Authors Placido E, Gomes Welter P, Wink A, Karasiak GD, Outeiro TF, Dafre AL, Gil-Mohapel J, Brocardo PS Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2023, 24(16), 12607. Abstract Huntington’s disease (HD) is a neurodegenerative genetic disorder characterized by motor, psychiatric, cognitive, and peripheral symptoms without
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14.09.2022

Skeletal Class III Malocclusion Is Associated with ADAMTS2 Variants and Reduced Expression in a Familial Case

Authors Yao S, Zhou X, Vona B, Fan L, Zhang C, Li D, Yuan H, Du Y, Ma L, Pan Y Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2022 Sep 14;23(18):10673. Abstract Skeletal Class III malocclusion with maxillary deficiency is a severe maxillofacial disease with unclear
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21.04.2022

A Reliable Approach for Revealing Molecular Targets in Secondary Ion Mass Spectrometry

Authors Li F, Fornasiero EF, Dankovich TM, Kluever V, Rizzoli SO Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2022, 23, 4615. Abstract Nano secondary ion mass spectrometry (nanoSIMS) imaging is a rapidly growing field in biological sciences, which enables investigators to describe the chemical composition of
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02.10.2020

Quantitative Synaptic Biology: A Perspective on Techniques, Numbers and Expectations

Authors Reshetniak S, Fernández-Busnadiego R, Müller M, Rizzoli SO, Tetzlaff C Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2020 Oct 2;21(19):E7298. Abstract Synapses play a central role for the processing of information in the brain and have been analyzed in countless biochemical, electrophysiological, imaging, and computational
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10.08.2020

The Role of Alpha-Synuclein and Other Parkinson’s Genes in Neurodevelopmental and Neurodegenerative Disorders

Authors Morato Torres CA, Wassouf Z, Zafar F, Sastre D, Outeiro TF, Schüle B Journal International Journal of Molecular Sciences Citation Int. J. Mol. Sci. 2020, 21(16), 5724. Abstract Neurodevelopmental and late-onset neurodegenerative disorders present as separateentities that are clinically and neuropathologically quite distinct. However, recent evidence hashighlighted surprising commonalities
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