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19.04.2022

Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons

Authors Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, Haass C, Mann M, Hartl FU, Baumeister W, Hipp MS, Meissner F, Fernández-Busnadiego R, Edbauer D Journal EMBO Reports Citation EMBO Rep. 2022 Apr 19:e53890. Abstract Aggregation of the multifunctional RNA-binding protein TDP-43 defines large subgroups of
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15.02.2021

Monitoring mitochondrial translation in living cells

Authors Yousefi R, Fornasiero EF, Cyganek L, Montoya J, Jakobs S, Rizzoli SO, Rehling P, Pacheu-Grau D Journal EMBO Reports Citation EMBO Rep. 2021 Feb 15:e51635. Abstract Mitochondria possess a small genome that codes for core subunits of the oxidative phosphorylation system and whose expression is essential for energy production.
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07.01.2020

MITRAC15/COA1 promotes mitochondrial translation in a ND2 ribosome-nascent chain complex

Authors Wang C, Richter-Dennerlein R, Pacheu-Grau D, Liu F, Zhu Y, Dennerlein S, Rehling P Journal EMBO Reports Citation EMBO Rep. 2020 Jan 7;21(1):e48833. Abstract The mitochondrial genome encodes for thirteen core subunits of the oxidative phosphorylation system. These proteins assemble with imported proteins in a modular manner into stoichiometric
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