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23.05.2025

Photoactivatable and Photolabile Pharmacophores: Lessons Learned from Capsaicin

Authors Imse B, Rojas L, Herrero CG, Thallmair S, Rhee JS, Simeth N Journal ChemRxiv Citation ChemRxiv. 2025. Abstract Light-controlled molecules have become valuable tools for studying biological systems offering an unparalleled control in space and time. Specifically, the remote-controllable (de)activation of small molecules is attractive to both study molecular
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22.01.2025

A Photoswitchable Tryptophan Zipper – (Un)folding Fibrils in Seconds

Authors Cotroneo ER, Cheng TC, Kaltschnee L, Maibach P, Engelke M, Schwegler N, Thomas F, Thiele CM, Simeth N Journal ChemRxiv Citation ChemRxiv. 2025. Abstract Peptides and proteins, that have the tendency to form aggregates, are often discussed in the context of Alz-heimer’s, Huntington’s, or Parkinson’s disease. However, studying aggregation
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