A small step towards an important goal: fragment screen of the c-di-AMP-synthesizing enzyme CdaA
Authors Neumann P, Heidemann JL, Wollenhaupt J, Dickmanns A, Agthe M, Weiss MS, Ficner R Journal Acta Crystallographica.Section D, Structural Biology Citation Acta Crystallogr D Struct Biol. 2024 May 1. Abstract CdaA is the most widespread diadenylate cyclase in many bacterial species, including several multidrug-resistant human pathogens. The enzymatic product