Multiscale Strategy to Resolve Stroma-Cardiac Fibroblast Interactions
Authors Zimmermann WH Journal Circulation Research Citation Circ Res. 2021 Jan 8;128(1):39-41. Abstract No abstract available. DOI 10.1161/CIRCRESAHA.120.318494 Pubmed Link
08.01.2021
07.10.2020
Inhibition of aquaporin-1 prevents myocardial remodeling by blocking the transmembrane transport of hydrogen peroxide
Authors Montiel V, Bella R, Michel LYM, Esfahani H, De Mulder D, Robinson EL, Deglasse JP, Tiburcy M, Chow PH, Jonas JC, Gilon P, Steinhorn B, Michel T, Beauloye C, Bertrand L, Farah C, Dei Zotti F, Debaix H, Bouzin C, Brusa D, Horman S, Vanoverschelde JL, Bergmann O, Gilis
29.07.2020
Developmental GABA polarity switch and neuronal plasticity in Bioengineered Neuronal Organoids
Authors Zafeiriou MP, Bao G, Hudson J, Halder R, Blenkle A, Schreiber MK, Fischer A, Schild D, Zimmermann WH Journal Nature Communications Citation Nat Commun 11, 3791 (2020). Abstract Brain organoids are promising tools for disease modeling and drug development. For proper neuronal network formation excitatory and inhibitory neurons as
06.07.2020
Intronic CRISPR Repair in a Preclinical Model of Noonan Syndrome-Associated Cardiomyopathy
Authors Hanses U, Kleinsorge M, Roos L, Yigit G, Li Y, Barbarics B, El-Battrawy I, Lan H, Tiburcy M, Hindmarsh R, Lenz C, Salinas G, Diecke S, Müller C, Adham I, Altmüller J, Nürnberg P, Paul T, Zimmermann WH, Hasenfuss G, Wollnik B, Cyganek L Journal Circulation Citation Circulation. 2020;10.1161/CIRCULATIONAHA.119.044794.
03.06.2020
Generation of Engineered Human Myocardium in a Multi-well Format
Authors Tiburcy M, Meyer T, Liaw NY, Zimmermann WH Journal STAR protocols Citation STAR Protoc. 2020 Jun 3;1(1):100032. Abstract This protocol describes a robust method for the generation of engineered human myocardium (EHM) from pluripotent stem cells (PSCs) in a multi-well plate under defined, serum-free conditions. By parallel culture of
19.05.2020
19th Annual Meeting of the Safety Pharmacology Society: Regulatory and Safety Perspectives for Advanced Therapy Medicinal Products (Cellular and Gene Therapy Products)
Authors Cavero I, Seimetz D, Koziel D, Zimmermann WH, Holzgrefe HH Journal Expert Opinion Drug Safety Citation Expert Opin Drug Saf. 2020 May;19(5):553-558. Abstract This report summarizes and discusses talks delivered at an educational course offered during the 2019 Annual Meeting of the Safety Pharmacology Society on advanced therapy medicinal
08.04.2020
Challenges to heart repair with pluripotent stem cell-derived cardiomyocytes
Authors Zimmermann WH Journal Trends in Cardiovascular Medicine Citation Trends Cardiovasc Med 2020 Apr 8;S1050-1738(20)30049-9 Abstract no abstract available DOI 10.1016/j.tcm.2020.03.006 Pubmed Link
01.04.2020
Tissue engineered heart repair from preclinical models to first-in-patient studies
Authors Zimmermann WH Journal Current Opinion in Physiology Citation Current Opinion in Physiology 2020, 14:70–77. Abstract The lack of regenerative therapies for the treatment of degenerative diseases, such as heart failure, motivates the search for cell therapeutics. From a technical point of view, cell-based heart repair is approached from two
