Zimmermann, Wolfram-Hubertus

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28.01.2024

Genome engineering of a neuronal specific, optogenetic, induced pluripotent stem cell line

Authors Schmoll KA, Mager T, Tse TP, Alameldeen A, Zimmermann WH, Zafeiriou MP Journal Stem Cell Research Citation Stem Cell Res. 2024 Jan 28;75:103317. Abstract Control of neuronal activity by optogenetic tools is increasingly explored in disease modelling and optogenetics and holds great promise for regenerative therapy. To investigate neuronal
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22.01.2024

Preclinical evaluation of CRISPR-based therapies for Noonan syndrome caused by deep-intronic LZTR1 variants

Authors Knauer C, Haltern H, Schoger E, Kügler S, Roos L, Zelarayán LC, Hasenfuss G, Zimmermann WH, Wollnik B, Cyganek L Journal Molecular Therapy: Nucleic Acids Citation Mol Ther Nucleic Acids. 2024 Jan 23;35(1):102123. Abstract Gene variants in LZTR1 are implicated to cause Noonan syndrome associated with a severe and
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20.12.2023

Protocol to develop force-generating human skeletal muscle organoids

Authors Shahriyari M, Rinn M, Hofemeier AD, Babych A, Zimmermann WH, Tiburcy M Journal Star Protocols Citation STAR Protoc. 2023 Dec 20;5(1):102794. Abstract Force generation is an essential property of skeletal muscle models in vitro. We describe a versatile 1-step procedure to direct undifferentiated human pluripotent stem cells (PSCs) into
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07.12.2023

Therapeutic efficacy of AAV-mediated restoration of PKP2 in arrhythmogenic cardiomyopathy

Authors Kyriakopoulou E, Versteeg D, de Ruiter H, Perini I, Seibertz F, Döring Y, Zentilin L, Tsui H, van Kampen S, Tiburcy M, Meyer T, Voigt N, van Tintelen J, Zimmermann W, Giacca M, van Rooij E Journal Nature Cardiovascular Research Citation Nat Cardiovasc Res 2, 1262–1276 (2023 Dec 07)
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28.09.2023

4D-Printable Photocrosslinkable Polyurethane-Based Inks for Tissue Scaffold and Actuator Applications

Authors Goodarzi Hosseinabadi H, Biswas A, Bhusal A, Yousefinejad A, Lall A, Zimmermann WH, Miri AK, Ionov L Journal Small Citation Small. 2023 Sep 28:e2306387. Abstract 4D printing recently emerges as an exciting evolution of conventional 3D printing, where a printed construct can quickly transform in response to a specific
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07.09.2023

Atrial fibrillation-associated electrical remodelling in human induced pluripotent stem cell-derived atrial cardiomyocytes: a novel pathway for antiarrhythmic therapy development

Authors Seibertz F, Rubio T, Springer R, Popp F, Ritter M, Liutkute A, Bartelt L, Stelzer L, Haghighi F, Pietras J, Windel H, Díaz I Pedrosa N, Rapedius M, Döring Y, Solano R, Hindmarsh R, Shi R, Tiburcy M, Brügmann T, Kutschka I, Streckfuss-Bömeke K, Kensah G, Cyganek L, Zimmermann
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19.08.2023

Bioengineering of a human innervated cardiac muscle model

Authors Schneider LV, Bao G, Methi A, Jensen O, Schmoll KA, Setya MG, Sakib MS, Fahud AL, Brockmoeller J, Fischer A, Liaw NY, Zimmermann WH, Zafeiriou MP Journal BioRxiv Citation bioRxiv 2023.08.18.552653. Abstract Cardiac autonomic neurons control cardiac contractility. Dysregulation of the autonomic nervous system can lead to sympathetic overdrive
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10.01.2023

LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome

Authors Busley AV, Gutiérrez-Gutiérrez O, Hammer E, Steinegger M, Böhmer L, Schroeder H, Kleinsorge M, Altmüller J, Marbach F, Hasenfuss G, Zimmermann WH, Wollnik B, Cyganek L Journal BioRxiv Citation bioRxiv 2023.01.10.523203. Abstract Noonan syndrome patients harboring causative variants in LZTR1 are particularly at risk to develop severe and early-onset
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23.12.2022

Dystrophin is a mechanical tension modulator

Authors Hofemeier AD, Muenker TM, Herkenrath F, Ristau M, Brandt M, Shahriyari M, Tiburcy M, Zimmermann WH, Lenz C, Mamchaoui K, Bigot A, Gilbert PM, Betz T Journal BioRxiv Citation bioRxiv 2022.12.23.521750. Abstract Duchenne muscular dystrophy (DMD) represents the most common inherited muscular disease, where increasing muscle weakness leads to
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16.11.2022

Somatic mosaicism in STAG2-associated cohesinopathies: Expansion of the genotypic and phenotypic spectrum

Authors Schmidt J, Dreha-Kulaczewski S, Zafeiriou MP, Schreiber MK, Wilken B, Funke R, Neuhofer CM, Altmüller J, Thiele H, Nürnberg P, Biskup S, Li Y, Zimmermann WH, Kaulfuß S, Yigit G, Wollnik B. Journal Frontiers in Cell and Developmental Biology Citation Front Cell Dev Biol. 2022 Nov 16;10:1025332. Abstract STAG2
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