Zimmermann, Wolfram-Hubertus

Authors Jebran AF, Tiburcy M, Biermann D, Balfanz P, Didié M, Karikkineth BC, Schöndube F, Kutschka I, Zimmermann WH Journal Journal of Molecular and Cellular Cardiology Citation J Mol Cell Cardiol. 2022 Apr 4;168:3-12. Abstract Engineered heart muscle (EHM) can be implanted epicardially to remuscularize the failing heart. In case

Authors Fomin A, Gärtner A, Cyganek L, Tiburcy M, Tuleta I, Wellers L, Folsche L, Hobbach AJ, von Frieling-Salewsky M, Unger A, Hucke A, Koser F, Kassner A, Sielemann K, Streckfuß-Bömeke K, Hasenfuss G, Goedel A, Laugwitz KL, Moretti A, Gummert JF, dos Remedios CG, Reinecke H, Knöll R, van

Authors Islam MR, Kaurani L, Berulava T, Heilbronner U, Budde M, Centeno TP, Elerdashvili V, Zafieriou MP, Benito E, Sertel SM, Goldberg M, Senner F, Kalman JL, Burkhardt S, Oepen AS, Sakib MS, Kerimolgu C, Wirths O, Bickeböller H, Bartels C, Brosseron F, Buerger K, Cosma NC, Fliessbach K, Heneka

Authors Schoger E, Zimmermann WH, Cyganek L, Zelarayán LC Journal Stem Cell Research Citation Stem Cell Res. 2021 Aug 26;56:102518. Abstract CRISPR/Cas9 technology based on nuclease inactive dCas9 and fused to the heterotrimeric VPR transcriptional activator is a powerful tool to enhance endogenous transcription by targeting defined genomic loci. We

Authors Santos GL, Meyer T, Tiburcy M, DeGrave A, Zimmermann WH, Lutz S Journal Journal of Visualized Experiments Citation J Vis Exp. 2021 Aug 20;(174). Abstract Fibroblasts are phenotypically highly dynamic cells, which quickly transdifferentiate into myofibroblasts in response to biochemical and biomechanical stimuli. The current understanding of fibrotic processes,

Authors Zimmermann WH Journal Cardiovascular Research Citation Cardiovasc Res. 2021 Aug 4:cvab229. Abstract No Abstract available. DOI 10.1093/cvr/cvab229 Pubmed Link  

Authors Schoger E, Zimmermann WH, Cyganek L, Zelarayán LC Journal Stem Cell Research Citation Stem Cell Res. 2021 Jul 27;55:102473. Abstract Using nuclease-deficient dead (d)Cas9 without enzymatic activity fused to transcriptional inhibitors (CRISPRi) allows for transcriptional interference and results in a powerful tool for the elucidation of developmental, homeostatic and

Authors Raad FS, Khan TA, Esser TU, Hudson JE, Seth BI, Fujita B, Gandamala R, Tietze LF, Zimmermann WH Journal EMBO Molecular Medicine Citation ChemMedChem. 2021 Jul 26. Abstract Human pluripotent stem cells (hPSCs) hold great promise for applications in cell therapy and drug screening in the cardiovascular field. Bone

Authors Hoffmann S, Schmitteckert S, Raedecke K, Rheinert D, Diebold S, Roeth R, Weiss B, Granzow M, Niesler B, Griesbeck A, Eckstein V, Zimmermann WH, Just S, Rappold GA Journal Biochimica et Biophysica Acta – Gene Regulatory Mechanisms Citation Biochim Biophys Acta Gene Regul Mech. 2021 Mar 8:194702. Abstract The

Authors Zheng X, Zhang L, Kuang Y, Venkataramani V, Jin F, Hein K, Zafeiriou MP, Lenz C, Moebius W, Kilic E, Hermann DM, Weber MS, Urlaub H, Zimmermann WH, Bähr M, Doeppner TR  Journal Translational Stroke Research Citation Transl. Stroke Res. 12, 185–203 (2021). Abstract Stem cells such as mesenchymal stem cells (MSCs) enhance neurological recovery in preclinical stroke models by secreting extracellular vesicles (EVs). Since previous reports have focused on the application of MSC-EVs