Zimmermann, Wolfram-Hubertus

Authors Schoger E, Zimmermann WH, Cyganek L, Zelarayán LC Journal Stem Cell Research Citation Stem Cell Res. 2021 Jul 27;55:102473. Abstract Using nuclease-deficient dead (d)Cas9 without enzymatic activity fused to transcriptional inhibitors (CRISPRi) allows for transcriptional interference and results in a powerful tool for the elucidation of developmental, homeostatic and

Authors Raad FS, Khan TA, Esser TU, Hudson JE, Seth BI, Fujita B, Gandamala R, Tietze LF, Zimmermann WH Journal EMBO Molecular Medicine Citation ChemMedChem. 2021 Jul 26. Abstract Human pluripotent stem cells (hPSCs) hold great promise for applications in cell therapy and drug screening in the cardiovascular field. Bone

Authors Hoffmann S, Schmitteckert S, Raedecke K, Rheinert D, Diebold S, Roeth R, Weiss B, Granzow M, Niesler B, Griesbeck A, Eckstein V, Zimmermann WH, Just S, Rappold GA Journal Biochimica et Biophysica Acta – Gene Regulatory Mechanisms Citation Biochim Biophys Acta Gene Regul Mech. 2021 Mar 8:194702. Abstract The

Authors Zheng X, Zhang L, Kuang Y, Venkataramani V, Jin F, Hein K, Zafeiriou MP, Lenz C, Moebius W, Kilic E, Hermann DM, Weber MS, Urlaub H, Zimmermann WH, Bähr M, Doeppner TR  Journal Translational Stroke Research Citation Transl. Stroke Res. 12, 185–203 (2021). Abstract Stem cells such as mesenchymal stem cells (MSCs) enhance neurological recovery in preclinical stroke models by secreting extracellular vesicles (EVs). Since previous reports have focused on the application of MSC-EVs

Authors Zimmermann WH Journal Circulation Research Citation Circ Res. 2021 Jan 8;128(1):39-41. Abstract No abstract available. DOI 10.1161/CIRCRESAHA.120.318494 Pubmed Link  

Authors Montiel V, Bella R, Michel LYM, Esfahani H, De Mulder D, Robinson EL, Deglasse JP, Tiburcy M, Chow PH, Jonas JC, Gilon P, Steinhorn B, Michel T, Beauloye C, Bertrand L, Farah C, Dei Zotti F, Debaix H, Bouzin C, Brusa D, Horman S, Vanoverschelde JL, Bergmann O, Gilis

Authors Zafeiriou MP, Bao G, Hudson J, Halder R, Blenkle A, Schreiber MK, Fischer A, Schild D, Zimmermann WH Journal Nature Communications Citation Nat Commun 11, 3791 (2020). Abstract Brain organoids are promising tools for disease modeling and drug development. For proper neuronal network formation excitatory and inhibitory neurons as

Authors Hanses U, Kleinsorge M, Roos L, Yigit G, Li Y, Barbarics B, El-Battrawy I, Lan H, Tiburcy M, Hindmarsh R, Lenz C, Salinas G, Diecke S, Müller C, Adham I, Altmüller J, Nürnberg P, Paul T, Zimmermann WH, Hasenfuss G, Wollnik B, Cyganek L Journal Circulation Citation Circulation. 2020;10.1161/CIRCULATIONAHA.119.044794.

Authors Tiburcy M, Meyer T, Liaw NY, Zimmermann WH Journal STAR protocols Citation STAR Protoc. 2020 Jun 3;1(1):100032. Abstract This protocol describes a robust method for the generation of engineered human myocardium (EHM) from pluripotent stem cells (PSCs) in a multi-well plate under defined, serum-free conditions. By parallel culture of

Authors Cavero I, Seimetz D, Koziel D, Zimmermann WH, Holzgrefe HH Journal Expert Opinion Drug Safety Citation Expert Opin Drug Saf. 2020 May;19(5):553-558. Abstract This report summarizes and discusses talks delivered at an educational course offered during the 2019 Annual Meeting of the Safety Pharmacology Society on advanced therapy medicinal