Zimmermann, Wolfram-Hubertus

Authors Haertter D, Hauke L, Driehorst T, Nishi K, Long J, Tiburcy M, Berecic B, Primeßnig A, Bao G, Cyganek L, Schmidt CF, Zimmermann WH Journal BioRxiv Citation bioRxiv 2025.04.29.650605. Abstract Cardiomyocyte function critically depends on sarcomere dynamics and their organization in myofibrils. To uncover how cardiomyocyte function emerges from

Authors Tiper Y, Xie Z, Hofemeier AD, Lad H, Luber M, Krawetz R, Betz T, Zimmermann WH, Morton AB, Segal SS, Gilbert PM. Journal American Journal of Physiology. Cell Physiology Citation Am J Physiol Cell Physiol. 2025 Feb 28. Abstract Skeletal muscle microtissues are engineered to develop therapies for restoring

Authors Jebran AF, Seidler T, Tiburcy M, Daskalaki M, Kutschka I, Fujita B, Ensminger S, Bremmer F, Moussavi A, Yang H, Qin X, Mißbach S, Drummer C, Baraki H, Boretius S, Hasenauer C, Nette T, Kowallick J, Ritter CO, Lotz J, Didié M, Mietsch M, Meyer T, Kensah G, Krüger

Authors Zhang JJ, Pogwizd SM, Fukuda K, Zimmermann WH, Fan C, Hare JM, Bolli R, Menasché P Journal Nature Reviews. Cardiology Citation Nat Rev Cardiol. 2024 Nov 15. Abstract Heart failure (HF) remains a leading cause of mortality, responsible for 13% of all deaths worldwide. The prognosis for patients with

Authors Ruiz-Orera J, Miller DC, Greiner J, Genehr C, Grammatikaki A, Blachut S, Mbebi J, Patone G, Myronova A, Adami E, Dewani N, Liang N, Hummel O, Muecke MB, Hildebrandt TB, Fritsch G, Schrade L, Zimmermann WH, Kondova I, Diecke S, van Heesch S, Hübner N Journal Nature Cardiovascular Research

Authors Haertter D, Hauke L, Driehorst T, Nishi K, Zimmermann WH, Schmidt CF Journal eLife Citation eLife 13:RP97321. Abstract Cardiac muscle function emerges from the coordinated contraction of sarcomeres in cardiomyocytes. Sarcomere dynamics are usually inferred from whole-cell or myofibril observations, assuming synchronized, uniform behavior. Here, we investigated how different

Authors Kim R, Nagel SH, Liaw NY, Zimmermann WH, Zelarayan LC, Schoger E Journal Stem Cell Research Citation Stem Cell Research (2024). Abstract The fluorescence ubiquitination cell cycle inhibitor (FUCCI) has been introduced to monitor cell cycle activity in living cells, including human induced pluripotent stem cells (hiPSC) and derived

Authors Busley AV, Gutiérrez-Gutiérrez Ó, Hammer E, Koitka F, Mirzaiebadizi A, Steinegger M, Pape C, Böhmer L, Schroeder H, Kleinsorge M, Engler M, Cirstea IC, Gremer L, Willbold D, Altmüller J, Marbach F, Hasenfuss G, Zimmermann WH, Ahmadian MR, Wollnik B, Cyganek L Journal Cell Reports Citation Cell Rep. 2024

Authors Shahriyari M, Rinn M, Hofemeier AD, Babych A, Zimmermann WH, Tiburcy M Journal Star Protocols Citation STAR Protoc. 2024 Mar 15;5(1):102794. Abstract Force generation is an essential property of skeletal muscle models in vitro. We describe a versatile 1-step procedure to direct undifferentiated human pluripotent stem cells (PSCs) into

Authors Schmoll KA, Mager T, Tse TP, Alameldeen A, Zimmermann WH, Zafeiriou MP Journal Stem Cell Research Citation Stem Cell Res. 2024 Jan 28;75:103317. Abstract Control of neuronal activity by optogenetic tools is increasingly explored in disease modelling and optogenetics and holds great promise for regenerative therapy. To investigate neuronal