Urlaub, Henning

Authors Weninger G, Pochechueva T, El Chami D, Luo X, Kohl T, Brandenburg S, Urlaub H, Guan K, Lenz C, Lehnart SE Journal Science Reports Citation Sci Rep. 2022 Jun 20;12(1):10387. Abstract Calpains are calcium-activated neutral proteases involved in the regulation of key signaling pathways. Junctophilin-2 (JP2) is a Calpain-specific

Authors Farkas Á, Urlaub H, Bohnsack KE, Schwappach B Journal Journal of Cell Biology Citation J Cell Biol. 2022 Jun 6;221(6):e202201036. Abstract The guided entry of tail-anchored proteins (GET) pathway targets C-terminally anchored transmembrane proteins and protects cells from lipotoxicity. Here, we reveal perturbed ergosterol production in ∆get3 cells and

Authors Upmanyu N, Jin J, Emde HV, Ganzella M, Bösche L, Malviya VN, Zhuleku E, Politi AZ, Ninov M, Silbern I, Leutenegger M, Urlaub H, Riedel D, Preobraschenski J, Milosevic I, Hell SW, Jahn R, Sambandan S Journal Neuron Citation Neuron. 2022 Mar 4:S0896-6273(22)00146-5. Abstract Vesicular transporters (VTs) define the

Authors Barbarics B, Eildermann K, Kaderali L, Cyganek L, Plessmann U, Bodemeyer J, Paul T, Ströbel P, Urlaub H, Tirilomis T, Lenz C, Bohnenberger H. Journal Scientific Reports Citation Sci Rep. 2021 Dec 22;11(1):24389. Abstract Aortic valve stenosis (AVS) is one of the most common valve diseases in the world.

Authors Fianu I, Chen Y, Dienemann Ch, Dybkov O, Linden A, Urlaub H, Cramer P Journal Science Citation Science. 2021 Nov 12;374(6569):883-887 Abstract Integrator and protein phosphatase 2A (PP2A) form a complex that dephosphorylates paused RNA polymerase II (Pol II), cleaves the nascent RNA, and terminates transcription. We report the

Authors Cruz-Zaragoza LD, Dennerlein S, Linden A, Yousefi R, Lavdovskaia E, Aich A, Falk RR, Gomkale R, Schöndorf T, Bohnsack MT, Richter-Dennerlein R, Urlaub H, Rehling P Journal Cell Citation Cell 2021 Oct 20. Abstract The human mitochondrial genome encodes thirteen core subunits of the oxidative phosphorylation system, and defects

Authors Gomkale R, Linden A, Neumann P, Schendzielorz AB, Stoldt S, Dybkov O, Kilisch M, Schulz C, Cruz-Zaragoza LD, Schwappach B, Ficner R, Jakobs S, Urlaub H, Rehling P Journal Nature Communications Citation Nat Commun 12, 5715 (2021) Abstract Nuclear-encoded mitochondrial proteins destined for the matrix have to be transported

Authors Kokic G, Wagner FR, Chernev A, Urlaub H, Cramer P Journal Nature Citation Nature 2021 Abstract Transcription-coupled DNA repair removes bulky DNA lesions from the genome and protects cells against ultraviolet (UV) irradiation. Transcription-coupled DNA repair begins when RNA polymerase II (Pol II) stalls at a DNA lesion and recruits

Authors Sievers K, Welp L, Urlaub H, Ficner R Journal RNA Biology Citation RNA Biol. 2021 Jul 31:1-15. Abstract The eukaryotic tRNA guanine transglycosylase (TGT) is an RNA modifying enzyme incorporating queuine, a hypermodified guanine derivative, into the tRNAsAsp,Asn,His,Tyr. While both subunits of the functional heterodimer have been crystallized individually,

Authors Chen Y, Vos SM, Dienemann C, Ninov M, Urlaub H, Cramer P Journal Molecular Cell Citation Molecular Cell (2021). In press. Abstract The super elongation complex (SEC) contains the positive transcription elongation factor b (P-TEFb) and the subcomplex ELL2-EAF1, which stimulates RNA polymerase II (RNA Pol II) elongation. Here,