Urlaub, Henning

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01.01.2020

Structure of the transcription coactivator SAGA

Authors Wang H, Dienemann C, Stutzer A, Urlaub H, Cheung ACM, Cramer P Journal Nature Citation Nature. 2020 Jan;577(7792):717-720. Abstract Gene transcription by RNA polymerase II is regulated by activator proteins that recruit the coactivator complexes SAGA (Spt-Ada-Gcn5-acetyltransferase)(1,2) and transcription factor IID (TFIID)(2-4). SAGA is required for all regulated transcription(5)
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12.12.2019

Structural Basis of Poxvirus Transcription: Vaccinia RNA Polymerase Complexes

Authors Grimm C, Hillen HS, Bedenk K, Bartuli J, Neyer S, Zhang Q, Huttenhofer A, Erlacher M, Dienemann C, Schlosser A, Urlaub H, Bottcher B, Szalay AA, Cramer P, Fischer U Journal Cell Citation Cell. 2019 Dec 12;179(7):1537-1550.e19. Abstract Poxviruses encode a multisubunit DNA-dependent RNA polymerase (vRNAP) that carries out
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08.12.2019

The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43

Authors Keihani S, Kluever V, Mandad S, Bansal V, Rahman R, Fritsch E, Gomes LC, Gartner A, Kugler S, Urlaub H, Wren JD, Bonn S, Rizzoli SO, Fornasiero EF Journal Science Advances Citation Sci Adv. 2019 Dec 18;5(12):eaay2670. Abstract The cellular and the molecular mechanisms by which long noncoding RNAs
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05.12.2019

A mass spectrometry workflow for measuring protein turnover rates in vivo

Authors Alevra M, Mandad S, Ischebeck T, Urlaub H, Rizzoli SO, Fornasiero EF Journal Nature Protocols Citation Nat Protoc. 2019 Dec;14(12):3333-3365. Abstract Proteins are continually produced and degraded, to avoid the accumulation of old or damaged molecules and to maintain the efficiency of physiological processes. Despite its importance, protein turnover
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20.08.2019

Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation

Authors Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L Jr, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHT Journal Circulation Citation Circulation. 2019 Aug 20;140(8):681-693. Abstract
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15.11.2018

The codon sequences predict protein lifetimes and other parameters of the protein life cycle in the mouse brain

Authors Mandad S, Rahman RU, Centeno TP, Vidal RO, Wildhagen H, Rammner B, Keihani S, Opazo F, Urban I, Ischebeck T, Kirli K, Benito E, Fischer A, Yousefi RY, Dennerlein S, Rehling P, Feussner I, Urlaub H, Bonn S, Rizzoli SO, Fornasiero EF Journal Scientific Reports Citation Sci Rep. 2018
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