Schwappach, Blanche

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01.09.2022

From guide to guard-activation mechanism of the stress-sensing chaperone Get3

Authors Ulrich K, Farkas Á, Chan O, Katamanin O, Schwappach B, Jakob U Journal Molecular Cell Citation Mol Cell. 2022 Sep 1;82(17):3226-3238.e7. Abstract Oxidative stress conditions can cause ATP depletion, oxidative protein unfolding, and potentially toxic protein aggregation. To alleviate this proteotoxic stress, the highly conserved yeast protein, Get3, switches
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06.06.2022

Regulated targeting of the monotopic hairpin membrane protein Erg1 requires the GET pathway

Authors Farkas Á, Urlaub H, Bohnsack KE, Schwappach B Journal Journal of Cell Biology Citation J Cell Biol. 2022 Jun 6;221(6):e202201036. Abstract The guided entry of tail-anchored proteins (GET) pathway targets C-terminally anchored transmembrane proteins and protects cells from lipotoxicity. Here, we reveal perturbed ergosterol production in ∆get3 cells and
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29.09.2021

Mapping protein interactions in the active TOM-TIM23 supercomplex

Authors Gomkale R, Linden A, Neumann P, Schendzielorz AB, Stoldt S, Dybkov O, Kilisch M, Schulz Ch, Cruz-Zaragoza LD, Schwappach B, Ficner R, Jakobs S, Henning Urlaub H, Rehling P Journal Nature Communications Citation Nat Commun 12, 5715 (2021) Abstract Nuclear-encoded mitochondrial proteins destined for the matrix have to be
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21.09.2021

Management of Metadata Types in Basic Cardiological Research

Authors Kusch H, Kossen R, Suhr M, Freckmann L, Weber L, Henke C, Lehmann C, Rheinländer S, Aschenbrandt G, Kühlborn LK, Marzec B, Menzel J, Schwappach B, Zelarayán LC, Cyganek L, Antonios G, Kohl T, Lehnart SE, Zoremba M, Sax U, Nussbeck SY Journal Studies in Health Technology and Informatics
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04.02.2021

Ribosome-bound Get4/5 facilitates the capture of tail-anchored proteins by Sgt2 in yeast

Authors Zhang Y, De Laurentiis E, Bohnsack KE, Wahlig M, Ranjan N, Gruseck S, Hackert P, Wölfle T, Rodnina MV, Schwappach B, Rospert S. Journal Nature Communications Citation Nat Commun. 2021 Feb 4;12(1):782. Abstract The guided entry of tail-anchored proteins (GET) pathway assists in the posttranslational delivery of tail-anchored proteins,
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09.12.2020

Post-Translational Modifications Soften Vimentin Intermediate Filaments

Authors Kraxner J, Lorenz C, Menzel J, Parfentev I, Silbern I, Denz M, Urlaub H, Schwappach B, Köster S Journal Nanoscale Citation Nanoscale. 2020 Dec 22. Abstract The mechanical properties of biological cells are determined by the cytoskeleton, a composite biopolymer network consisting of microtubules, actin filaments and intermediate filaments
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01.10.2020

Structural Basis of Tail-Anchored Membrane Protein Biogenesis by the GET Insertase Complex

Authors McDowell MA, Heimes M, Fiorentino F, Mehmood S, Farkas Á, Coy-Vergara J, Wu D, Bolla JR, Schmid V, Heinze R, Wild K, Flemming D, Pfeffer S, Schwappach B, Robinson CV, Sinning I Journal Molecular Cell Citation Mol Cell. 2020 Oct 1;80(1):72-86.e7. Abstract Membrane protein biogenesis faces the challenge of
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01.09.2020

14-3-3 binding creates a memory of kinase action by stabilizing the modified state of phospholamban

Authors Menzel J, Kownatzki-Danger D, Tokar S, Ballone A, Unthan-Fechner K, Kilisch M, Lenz C, Urlaub H, Mori M, Ottmann C, Shattock MJ, Lehnart SE, Schwappach B Journal Science Signaling Citation Sci Signal. 2020 Sep 1;13(647):eaaz1436. Abstract The cardiac membrane protein phospholamban (PLN) is targeted by protein kinase A (PKA)
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