Salditt, Tim

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15.11.2021

Three-dimensional virtual histology of the cerebral cortex based on phase-contrast X-ray tomography

Authors Eckermann M, van der Meer F, Cloetens P, Ruhwedel T, Möbius W, Stadelmann C, Salditt T Journal Biomedical Optics Express Citation Biomed. Opt. Express 12, 7582-7598 (2021). Abstract In this work, we optimize the setups and experimental parameters of X-ray phase-contrast computed-tomography for the three-dimensional imaging of the cyto-
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23.03.2021

Multiscale photonic imaging of the native and implanted cochlea

Authors Keppeler D, Kampshoff C, Thirumalai A, Duque-Afonso CJ, Schaeper J, Quilitz T, Töpperwien M, Vogl C, Hessler R, Meyer A, Salditt T, Moser T Journal PNAS Citation PNAS May 4, 2021 118 (18) e2014472118. Abstract The cochlea of our auditory system is an intricate structure deeply embedded in the
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15.12.2020

Combined scanning small-angle X-ray scattering and holography probes multiple length scales in cell nuclei

Authors Wittmeier A, Cassini C, Töpperwien M, Denz M, Hagemann J, Osterhoff M, Salditt T, Köster S Journal Journal of Synchrotron Radiation Citation J Synchrotron Rad (2021) 28. Abstract X-rays are emerging as a complementary probe to visible-light photons and electrons for imaging biological cells. By exploiting their small wavelength
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09.11.2020

X-ray diffraction and second harmonic imaging reveal new insights into structural alterations caused by pressure-overload in murine hearts

Authors Nicolas JD, Khan A, Markus A, Mohamed BA, Toischer K, Alves F, Salditt T Journal Scientific Reports Citation Sci Rep. 2020 Nov 9;10(1):19317. Abstract We demonstrate a label-free imaging approach to study cardiac remodeling of fibrotic and hypertrophic hearts, bridging scales from the whole organ down to the molecular
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06.10.2020

3d phase-contrast nanotomography of unstained human skin biopsies may identify morphological differences in the dermis and epidermis between subjects

Authors Eckermann M, Peruzzi N, Frohn J, Bech M, Englund E, Veress B, Salditt T, Dahlin LB, Ohlsson B Journal Skin Research and Technology Citation Skin Res Technol. 2020 Oct 6. Abstract BACKGROUND: Enteric neuropathy is described in most patients with gastrointestinal dysmotility and may be found together with reduced
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06.10.2020

X-ray structural analysis of single adult cardiomyocytes: tomographic imaging and micro-diffraction

Authors Reichardt M, Neuhaus C, Nicolas JD, Bernhardt M, Toischer K, Salditt T Journal Biophysical Journal Citation Biophys J. 2020 Oct 6;119(7):1309-1323. Abstract We present a multi-scale imaging approach to characterize the structure of isolated adult murine cardiomyocytes based on a combination of full-field three-dimensional (3d) coherent x-ray imaging and
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09.09.2020

3D analysis of the myenteric plexus of the human bowel by X-ray phase-contrast tomography – a future method?

Authors Peruzzi N, Veress B, Dahlin LB, Salditt T, Andersson M, Eckermann M, Frohn J, Robisch AL, Bech M, Ohlsson B Journal Scandinavian Journal of Gastroenterology Citation Scand J Gastroenterol. 2020 Oct;55(10):1261-1267. Abstract Objectives: Light microscopical analysis in two dimensions, combined with immunohistochemistry, is presently the gold standard to describe
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20.08.2020

3d Virtual Pathohistology of Lung Tissue from Covid-19 Patients based on Phase Contrast X-ray Tomography

Authors Eckermann M, Frohn J, Reichardt M, Osterhoff M, Sprung M, Westermeier F, Tzankov A, Werlein C, Kuehnel M, Jonigk D, Salditt T Journal Elife Citation eLife 2020;9:e60408. Abstract We present a three-dimensional (3D) approach for virtual histology and histopathology based on multi-scale phase contrast x-ray tomography, and use this
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18.08.2020

3D virtual histology of human pancreatic tissue by multiscale phase-contrast X-ray tomography

Authors Frohn J, Pinkert-Leetsch D, Missbach-Güntner J, Reichardt M, Osterhoff M, Alves F, Salditt T Journal Journal of Synchrotron Radiation Citation J. Synchrotron Rad. (2020). 27, 1707-1719. Abstract A multiscale three-dimensional (3D) virtual histology approach is presented, based on two configurations of propagation phase-contrast X-ray tomography, which have been implemented
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06.05.2020

Vesicle adhesion in the electrostatic strong- coupling regime studied by time-resolved small-angle X-ray scattering

Authors Komorowski K, Schaeper J, Sztucki M, Sharpnack L, Brehm G, Köster S, Salditt T Journal Soft Matter Citation Soft Matter. 2020 May 6;16(17):4142-4154. Abstract We have used time-resolved small-angle X-ray scattering (SAXS) to study the adhesion of lipid vesicles in the electrostatic strong-coupling regime induced by divalent ions. The
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