Moser, Tobias

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15.09.2021

RIM-Binding Protein 2 Organizes Ca2+ Channel Topography and Regulates Release Probability and Vesicle Replenishment at a Fast Central Synapse

Authors Butola T, Alvanos T, Hintze A, Koppensteiner P, Kleindienst D, Shigemoto R, Wichmann C, Moser T Journal Journal of Neuroscience Citation J. Neurosci. 2021, 41 (37) 7742-7767 Abstract Rab-interacting molecule (RIM)-binding protein 2 (BP2) is a multidomain protein of the presynaptic active zone (AZ). By binding to RIM, bassoon
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20.08.2021

Cabp2-Gene Therapy Restores Inner Hair Cell Calcium Currents and Improves Hearing in a DFNB93 Mouse Model

Authors Oestreicher D, Picher MM, Rankovic V, Moser T, Pangrsic T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 2021, 14:689415. Abstract Clinical management of auditory synaptopathies like other genetic hearing disorders is currently limited to the use of hearing aids or cochlear implants. However, future gene therapy promises restoration of
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07.05.2021

Utility of red-light ultrafast optogenetic stimulation of the auditory pathway

Authors Bali B, Lopez de la Morena D, Mittring A, Mager T, Rankovic V, Huet AT, Moser T Journal EMBO Molecular Medicine Citation EMBO Mol Med. 2021 May 7:e13391. Abstract Optogenetic stimulation of spiral ganglion neurons (SGNs) in the ear provides a future alternative to electrical stimulation used in current
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23.03.2021

RIM-binding proteins are required for normal sound-encoding at afferent inner hair cell synapses

Authors Krinner S, Predoehl F, Burfeind D, Vogl C, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 14:651935. Abstract The afferent synapses between inner hair cells (IHC) and spiral ganglion neurons are specialized to faithfully encode sound with sub-millisecond precision over prolonged periods of time. Here, we
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23.03.2021

Multiscale photonic imaging of the native and implanted cochlea

Authors Keppeler D, Kampshoff C, Thirumalai A, Duque-Afonso CJ, Schaeper J, Quilitz T, Töpperwien M, Vogl C, Hessler R, Meyer A, Salditt T, Moser T Journal PNAS Citation PNAS May 4, 2021 118 (18) e2014472118. Abstract The cochlea of our auditory system is an intricate structure deeply embedded in the
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11.03.2021

Developing fast, red-light optogenetic stimulation of spiral ganglion neurons for future optical cochlear implants

Authors Huet AT, Dombrowsik T, Rankovic V, Thirumalai A, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 14:635897. Abstract Optogenetic stimulation of type I spiral ganglion neurons (SGNs) promises an alternative to the electrical stimulation by current cochlear implants (CIs) for improved hearing restoration by future optical
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07.01.2021

Understanding and treating paediatric hearing impairment

Authors Wrobel C, Zafeiriou MP, Moser T Journal EBioMedicine Citation EBioMedicine. 2021 Jan 7;63:103171. Abstract Sensorineural hearing impairment is the most frequent form of hearing impairment affecting 1–2 in 1000 newborns and another 1 in 1000 adolescents. More than 50% of congenital hearing impairment is of genetic origin and some
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07.01.2021

Overloaded Adeno-Associated Virus as a Novel Gene Therapeutic Tool for Otoferlin-Related Deafness

Authors Rankovic V, Vogl C, Dörje N M, Bahader I, Duque-Afonso C J, Thirumalai A, Weber T, Kusch K, Strenzke N, Moser T Journal Frontiers in Molecular Neuroscience Citation Front. Mol. Neurosci. 13:600051. Abstract Hearing impairment is the most common sensory disorder in humans. So far, rehabilitation of profoundly deaf
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05.01.2021

Electron Microscopic Reconstruction of Neural Circuitry in the Cochlea

Authors Hua Y, Ding X, Wang H, Wang F, Lu Y, Neef J, Gao Y, Moser T, Wu H Journal Cell Reports Citation Cell Rep. 2021 Jan 5;34(1):108551. Abstract Recent studies reveal great diversity in the structure, function, and efferent innervation of afferent synaptic connections between the cochlear inner hair
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21.12.2020

A sensory cell diversifies its output by varying Ca2+ influx-release coupling among active zones

Authors Özcete Ö, Moser T Journal EMBO Journal Citation EMBO J (2020)e106010. Abstract The cochlea encodes sound pressures varying over six orders of magnitude by collective operation of functionally diverse spiral ganglion neurons (SGNs). The mechanisms enabling this functional diversity remain elusive. Here, we asked whether the sound intensity information,
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