Moser, Tobias

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30.04.2025

Gating of hair cell Ca2+ channels governs the activity of cochlear neurons

Authors Karagulyan N, Thirumalai A, Michanski S, Qi Y, Fang Q, Wang H, Ortner NJ, Striessnig J, Strenzke N, Wichmann C, Hua Y, Moser T Journal Science Advances Citation Sci Adv. 2025. accepted manuscript. Abstract Our sense of hearing processes sound intensities spanning six orders of magnitude. In the ear,
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28.04.2025

3D imaging of the human temporal bone by X-ray phase-contrast tomography

Authors Schaeper JJ, Tafforeau P, Kampshoff CA, Thomas C, Meyer A, Stadelmann C, Liberman MC, Moser T, Salditt T Journal npj Imaging Citation npj Imaging, 2025, accepted manuscript Abstract No abstract available. DOI No DOI available.
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28.04.2025

Investigation of neuromodulation of the endbulb of Held synapse in the cochlear nucleus by serotonin and norepinephrine

Authors Groshkova MB, Alvanos T, Qi Y, Wang F, Wichmann C, Hua Y, Moser T Journal Frontiers in Cellular Neuroscience Citation Front. Cell. Neurosci., 28 April 2025 Abstract Introduction: Synapses vary greatly in synaptic strength and plasticity, even within the same circuitry or set of pre- and postsynaptic neurons. Neuromodulation
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25.04.2025

Charting the nanotopography of inner hair cell synapses using MINFLUX nanoscopy

Authors Kapoor R, Kim H, Garlick E, Lima MARBF, Ruhwedel T, Moebius W, Wolf F, Moser T Journal BioRxiv Citation bioRxiv 2025.04.22.649963. Abstract For us to hear, the cochlea encodes sounds into neural signals at synapses of inner hair cells (IHCs) and the auditory nerve with remarkable fidelity. To achieve
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25.04.2025

Structural Basis of Lipid Membrane Binding by Human Ferlins

Authors Cretu C, Chernev A, Szabo CZK, Pena V, Urlaub H, Moser T, Preobraschenski J Journal EMBO Journal Citation EMBO J. 2025. accepted manuscript. Abstract Ferlins, ancient membrane proteins with a unique architecture, are central to multiple essential, Ca2+-dependent vesicle fusion processes. Despite numerous functional studies and their link to
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18.03.2025

Improved optogenetic modification of the spiral ganglion neurons for future optical cochlear implants

Authors Thirumalai A, Henseler J, Enayati M, Kusch K, Hessler R, Moser T, Huet AT Journal Theranostics Citation Theranostics 2025; 15(10):4270-4286. Abstract Optogenetic stimulation has become a promising approach for restoring lost body function. For example, partial restoration of vision has been achieved in a blind patient and preclinical proof-of-concept
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07.03.2025

3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography

Authors Schaeper JJ, Kampshoff CA, Wolf BJ, Roos L, Michanski S, Ruhwedel T, Eckermann M, Meyer A, Jeschke M, Wichmann C, Moser T, Salditt T Journal Scientific Reports Citation Sci Rep. 2025 Mar 7;15(1):7933. Abstract Multi-scale X-ray phase contrast tomography (XPCT) enables three-dimensional (3D), non-destructive imaging of intact small animal
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21.02.2025

Isotropic, aberration-corrected light sheet microscopy for rapid high-resolution imaging of cleared tissue

Authors Aakhte M, Mueller GF, Li J, Weiss KR, Roos L, Diniz AM, Wenzel J, Schwaninger M, Moser T, Huisken J Journal BioRxiv Citation bioRxiv 2025.02.21.639411. Abstract Light sheet microscopy is the ideal technique for multiscale imaging of large and cleared tissues, and it is desirable to achieve the highest
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12.02.2025

Probing the role of synaptic adhesion molecule RTN4RL2 in setting up cochlear connectivity

Authors Karagulyan N, Überegger M, Qi Y, Babai N, Hofer F, Johnson Chacko L, Wang F, Luque M, Glueckert R, Schrott-Fischer A, Hua Y, Moser T, Bandtlow C Journal eLife Citation eLife14:RP103481. Abstract Sound encoding depends on the precise and reliable neurotransmission at the afferent synapses between the sensory inner
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24.12.2024

Bridging the gap between presynaptic hair cell function and neural sound encoding

Authors Jaime Tobón LM, Moser T Journal eLife Citation Elife. 2024 Dec 24;12:RP93749. Abstract Neural diversity can expand the encoding capacity of a circuitry. A striking example of diverse structure and function is presented by the afferent synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in the
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