Fernandez-Busnadiego, Ruben

Authors Riera-Tur I, Schäfer T, Hornburg D, Mishra A, da Silva Padilha M, Fernández-Mosquera L, Feigenbutz D, Auer P, Mann M, Baumeister W, Klein R, Meissner F, Raimundo N, Fernández-Busnadiego R, Dudanova I Journal Life Science Alliance Citation Life Sci Alliance. 2021 Dec 21;5(3):e202101185. Abstract The autophagy-lysosomal pathway is impaired

Authors Eisenberg-Bord M, Zung N, Collado J, Drwesh L, Fenech EJ, Fadel A, Dezorella N, Bykov YS, Rapaport D, Fernandez-Busnadiego R, Schuldiner M Journal Journal of Cell Biology Citation J Cell Biol. 2021 Nov 1;220(11):e202104100. Abstract Mitochondrial functions are tightly regulated by nuclear activity, requiring extensive communication between these organelles.

Authors Huang B, Guo Q, Niedermeier ML, Cheng J, Engler T, Maurer M, Pautsch A, Baumeister W, Stengel F, Kochanek S, Fernández-Busnadiego R Journal Structure Citation Structure 2021 Apr 26:S0969-2126(21)00119-2 (in press). Abstract The abnormal amplification of a CAG repeat in the gene coding for huntingtin (HTT) leads to Huntington’s

Authors Baeuerlein FJB, Pastor-Pareja JC, Fernandez-Busnadiego R Journal bioRxiv Citation bioRxiv 2021.04.14.437159. Abstract Cryo-focused ion beam (cryo-FIB) milling allows thinning vitrified cells for high resolution imaging by cryo-electron tomography (cryo-ET). However, it remains challenging to apply this workflow to tissues, as they usually require high-pressure freezing for vitrification. Here we

Authors Trinkaus VA, Riera-Tur I, Martínez-Sánchez A, Bäuerlein FJB, Guo Q, Arzberger T, Baumeister W, Dudanova I, Hipp MS, Hartl FU, Fernández-Busnadiego R Journal Nature Communications Citation Nat Commun 12, 2110 (2021). Abstract The molecular architecture of α-Synuclein (α-Syn) inclusions, pathognomonic of various neurodegenerative disorders, remains unclear. α-Syn inclusions were

Authors Seefelder M, Alva V, Huang B, Engler T, Baumeister W, Guo Q, Fernández-Busnadiego R, Lupas AN, Kochanek S Journal BMC Evolutionary Biology Citation BMC Evol Biol. 2020 Dec 9;20(1):162. Abstract Background The huntingtin-associated protein 40 (HAP40) abundantly interacts with huntingtin (HTT), the protein that is altered in Huntington’s disease

Authors Bäuerlein FJB, Fernandez-Busnadiego R, Baumeister W Journal Trends in Cell Biology Citation Trends Cell Biol. 2020 Dec;30(12):951-966. Abstract Neurodegenerative diseases affect the lives of millions of people across the world, being particularly prevalent in the aging population. Despite huge research efforts, conclusive insights into the disease mechanisms are still

Authors Reshetniak S, Fernández-Busnadiego R, Müller M, Rizzoli SO, Tetzlaff C Journal International Journal of Molecular Sciences Citation Int J Mol Sci. 2020 Oct 2;21(19):E7298. Abstract Synapses play a central role for the processing of information in the brain and have been analyzed in countless biochemical, electrophysiological, imaging, and computational

Authors Salfer M, Collado JF, Baumeister W, Fernández-Busnadiego R, Martínez-Sánchez A Journal PLoS Computational Biology Citation PLoS Comput Biol. 2020 Aug 10;16(8):e1007962. Online ahead of print. Abstract Curvature is a fundamental morphological descriptor of cellular membranes. Cryo-electron tomography (cryo-ET) is particularly well-suited to visualize and analyze membrane morphology in a

Authors Yasuda S, Tsuchiya H, Kaiho A, Guo Q, Ikeuchi K, Endo A, Arai N, Ohtake F, Murata S, Inada T, Baumeister W, Fernandez-Busnadiego R, Tanaka K, Saeki Y Journal Nature Citation Nature. 2020 Feb;578(7794):296-300. Abstract The proteasome is a major proteolytic machine that regulates cellular proteostasis through selective degradation