Fernandez-Busnadiego, Ruben

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16.02.2024

A metabolically controlled contact site between vacuoles and lipid droplets in yeast

Authors Diep DTV, Collado J, Hugenroth M, Fausten RM, Percifull L, Wälte M, Schuberth C, Schmidt O, Fernández-Busnadiego R, Bohnert M   Journal Developmental Cell   Citation Dev Cell. 2024 Feb 16:S1534-5807(24)00036-4.   Abstract The lipid droplet (LD) organization proteins Ldo16 and Ldo45 affect multiple aspects of LD biology in
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25.01.2024

Vesicle condensation induced by synapsin: condensate size, geometry, and vesicle shape deformations

Authors Alfken J, Neuhaus C, Major A, Taskina A, Hoffmann C, Ganzella M, Petrovic A, Zwicker D, Fernández-Busnadiego R, Jahn R, Milovanovic D, Salditt T Journal European Physical Journey. E, Soft Matter Citation Eur Phys J E Soft Matter. 2024 Jan 25;47(1):8. Abstract We study the formation of vesicle condensates
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02.01.2024

Mechanism of human PINK1 activation at the TOM complex in a reconstituted system

Authors Raimi OG, Ojha H, Ehses K, Dederer V, Lange SM, Polo Rivera C, Deegan TD, Chen Y, Wightman M, Toth R, Labib KPM, Mathea S, Ranson N, Fernández-Busnadiego R, Muqit MMK Journal BioRxiv Citation bioRxiv 2023.12.23.573181. Abstract Loss of function mutations in PTEN-induced kinase 1 (PINK1) are a frequent
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20.11.2023

Helical superstructures between amyloid and collagen VI in heart-derived fibrils from a patient with Light Chain Amyloidosis

Authors Ricagno S, Schulte T, Chaves-Sanjuan A, Speranzini V, Sicking K, Mazzini G, Rognoni P, Caminito S, Milani P, Marabelli C, Corbelli A, Diomede L, Fiordaliso F, Anastasia L, Pappone C, Merlini G, Bolognesi M, Nuvolone M, Fernandez-Busnadiego R, Palladini G Journal Research Square Citation Research Square 2023. 20 Nov
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30.10.2023

Mammalian oocyes store proteins for the early embryo on cytoplasmic lattices

Authors Ida M.A. Jentoft, Felix J.B. Bäuerlein, Luisa M. Welp, Benjamin H. Cooper, Arsen Petrovic, Chun So, Sarah Mae Penir, Antonio Z. Politi, Yehor Horokhovskyi, Iina Takala, Heike Eckel, Rüdiger Moltrecht, Peter Lénárt, Tommaso Cavazza, Juliane Liepe, Nils Brose, Henning Urlaub, Rubén Fernández-Busnadiego, Melina Schuh Journal Cell Citation Cell, 2023,
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30.06.2023

Cryo-electron tomography of large biological specimens vitrified by plunge freezing

Authors Baeuerlein FJB, Renner M, El Chami D, Lehnart SE, Pastor-Pareja JC, Fernandez-Busnadiego R Journal BioRxiv Citation bioRxiv 2021.04.14.437159. Abstract Cryo-focused ion beam (cryo-FIB) milling allows thinning vitrified cells for high resolution imaging by cryo-electron tomography (cryo-ET). However, it remains challenging to apply this workflow to voluminous biological specimens such
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02.02.2023

The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system

Authors Saha I, Yuste-Checa P, Da Silva Padilha M, Guo Q, Körner R, Holthusen H, Trinkaus VA, Dudanova I, Fernández-Busnadiego R, Baumeister W, Sanders DW, Gautam S, Diamond MI, Hartl FU, Hipp MS Journal Nature Communications Citation Nat Commun. 2023 Feb 2;14(1):560. Abstract Amyloid-like aggregates of the microtubule-associated protein Tau
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16.07.2022

Huntingtin and Its Partner Huntingtin-Associated Protein 40: Structural and Functional Considerations in Health and Disease

Authors Seefelder M, Klein FAC, Landwehrmeyer B, Fernández-Busnadiego R, Kochanek S Journal Journal of Huntington’s Disease Citation J Huntingtons Dis. 2022 Jul 16. Abstract Since the discovery of the mutation causing Huntington’s disease (HD) in 1993, it has been debated whether an expanded polyglutamine (polyQ) stretch affects the properties of
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19.04.2022

Gel-like inclusions of C-terminal fragments of TDP-43 sequester stalled proteasomes in neurons

Authors Riemenschneider H, Guo Q, Bader J, Frottin F, Farny D, Kleinberger G, Haass C, Mann M, Hartl FU, Baumeister W, Hipp MS, Meissner F, Fernández-Busnadiego R, Edbauer D Journal EMBO Reports Citation EMBO Rep. 2022 Apr 19:e53890. Abstract Aggregation of the multifunctional RNA-binding protein TDP-43 defines large subgroups of
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21.12.2021

Amyloid-like aggregates cause lysosomal defects in neurons via gain-of-function toxicity

Authors Riera-Tur I, Schäfer T, Hornburg D, Mishra A, da Silva Padilha M, Fernández-Mosquera L, Feigenbutz D, Auer P, Mann M, Baumeister W, Klein R, Meissner F, Raimundo N, Fernández-Busnadiego R, Dudanova I Journal Life Science Alliance Citation Life Sci Alliance. 2021 Dec 21;5(3):e202101185. Abstract The autophagy-lysosomal pathway is impaired
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