2026

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22.08.2026

Distinct mitochondrial DNA single-nucleotide variant signatures in TOP3A-deficient cardiomyocytes

Authors Gaubert M, Alachram H, Gönenç II, Domínguez I, Argyriou C, Schmidt J, Kaulfuß S, Pavez-Giani M, Schott CT, Munk A, Zibat A, Cyganek L, Yigit G, Wollnik B Journal BioRxiv Citation bioRxiv 2026.08.18.745450. Abstract The human heart has a continuous and exceptionally high demand for energy, which is met
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Prof. Dr. Peter Rehling, director of the Institute for Cell Biochemistry, UMG. Photo: MBExC

21.08.2026

Peter Rehling Elected to the Polish Academy of Sciences

The Polish Academy of Sciences has elected new foreign members. MBExC member Prof. Dr. Peter Rehling, director of the Institute for Cell Biochemistry at the University Medical Center Göttingen (UMG), will become a new member of Division II for Biological and Agricultural Sciences. Membership in the Polish Academy of Sciences
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18.08.2026

Dielectric Interfaces Reshape Dynamic Single-Molecule Optical Fingerprints in Nanoscopic Polymer Films

Authors Marx D, Malsbenden D, Gligonov I, Wöll D, Enderlein J, Nevskyi O Journal ChemRxiv Citation ChemRxiv. 18 August 2026. Abstract Fluorescence lifetimes near dielectric interfaces depend on molecular dipole orientation, but this relationship becomes more complex when emitters are confined within finite nanoscopic films. Here, we combine radially polarized
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14.08.2026

Adaptation of OXPHOS biogenesis to cellular requirements

Authors Dennerlein S, Rehling P Journal Protein Science Citation Protein Sci. 2026 Sep;35(9):e70763. Abstract Metabolic cues regulate the formation of the mitochondrial OXPHOS machinery. These regulatory processes are tightly linked to mitochondrial translation, proteolytic degradation of unassembled subunits, and the formation of supercomplexes, creating checkpoints at which nutrient availability, oxygen
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11.08.2026

Optimizing infectious disease mitigation under dynamic conditions

Authors Müller L, Sartori F, Dehning J, Eggl MF, Priesemann V Journal Proceedings of the National Academy of Sciences of the USA Citation Proc Natl Acad Sci U S A. 2026 Aug 11;123(32):e2527395123. Abstract Mitigation measures are essential for controlling the spread of infectious diseases during pandemics and epidemics, but
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11.08.2026

ONE microscopy

Authors Shaib AH, Alawieh MM, Rizzoli SO Journal Nature Protocols Citation Nat Protoc. 2026 Aug 11. Abstract The introduction of expansion microscopy (ExM), a decade ago, marked a shift in super-resolution imaging, by physically separating fluorophores to bypass the diffraction limit. Numerous ExM developments have extended the method’s reach since,
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Many snapshots of the cancer protein p53, superimposed on top of one another and color-coded, illustrate the complex motion patterns of this intrinsically disordered protein. Some of the transient structural elements appear as “helix-like structures”. © Dániel Szöllősi / MPI-NAT

10.08.2026

Cancer protein p53 observed in action: more order than expected

Cancer occurs when cells divide uncontrollably and displace healthy cells. Tumor suppressors provide an important defense against this. As molecular growth inhibitors, they prevent healthy cells from becoming cancerous. A key protein among them is p53, also known as the “guardian of the genome”. If p53 detects errors in a
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06.08.2026

“Heart-in-the-dish” models identify mechanisms of diastolic dysfunction

Authors Dittrich GM, Zimmermann WH. Journal Cell Stem Cell Citation Cell Stem Cell. 2026 Aug 6;33(8):1243-1245. Abstract Modeling of cardiac pathologies in tissue-engineered models is coming of age. Two independent studies by Reid et al.1 and Tani et al.2 present in-depth multi-phenomics data from a human cardiac organoid (hCO) model
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03.08.2026

A microfluidics platform for studying ion and solute transport by isolated synaptic vesicles

Authors Upmanyu N, Olsthoorn L, Leon S, Sambandan S, Perego E, Mimoso T, Socrier L, Cretich M, Chiari M, Steinem C, Köster S, Jahn R Journal Colloids and Surfaces B: Biointerfaces Citation Colloids Surf B Biointerfaces. 2026 Aug 3;268(Pt 2):116020. Abstract Loading of synaptic vesicles with neurotransmitters, an essential step
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31.07.2026

SGLT2 inhibition improves sarcomere contractile dysfunction in human models of dilated cardiomyopathy

Authors Plota D, Nosheen Saleem H, Lin KH, Wali R, Cheruiyot C, Münzel L, Hutschenreiter T, Tiburcy M, Meyer T, Habeck M, Wiedmann F, Schmidt C, Zimmermann WH, Ebert A Journal Journal of Translational Medicine Citation J Transl Med (2026). Abstract Background: Sodium–glucose cotransporter 2 inhibitors (SGLT2i) are now widely
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