2025

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22.03.2025

Number and relative abundance of synaptic vesicles in functionally distinct priming states determine synaptic strength and short-term plasticity

Authors Lin KH, Ranjan M, Lipstein N, Brose N, Neher E, Taschenberger H Journal The Journal of Physiology Citation J Physiol. 2025 Mar 22. Abstract Heterogeneity in synaptic strength and short-term plasticity (STP) was characterized in post-hearing rat calyx of Held synapses at near-physiological external [Ca2+] under control conditions and
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21.03.2025

In situ architecture of the human prohibitin complex

Authors Lange F, Ratz M, Dohrke JN, Wenzel D, Ilgen P, Riedel D, Jakobs S Journal Nature Cell Biology Citation Nat Cell Biol (2025). Abstract Prohibitins are a highly conserved family of proteins that have been implicated in a variety of functions including mitochondrial stress signalling and housekeeping, cell cycle
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18.03.2025

Improved optogenetic modification of the spiral ganglion neurons for future optical cochlear implants

Authors Thirumalai A, Henseler J, Enayati M, Kusch K, Hessler R, Moser T, Huet AT Journal Theranostics Citation Theranostics 2025; 15(10):4270-4286. Abstract Optogenetic stimulation has become a promising approach for restoring lost body function. For example, partial restoration of vision has been achieved in a blind patient and preclinical proof-of-concept
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13.03.2025

Ca2+-triggered (de)ubiquitination events in synapses

Authors Ainatzi S, Kaufmann SV, Silbern I, Georgiev SV, Lorenz S, Rizzoli SO, Urlaub H Journal Molecular & Cellular Proteomics Citation Mol Cell Proteomics. 2025 Mar 13:100946. Abstract Neuronal communication relies on neurotransmitter release from synaptic vesicles (SVs), whose dynamics are controlled by Ca2+-dependent pathways, as many thoroughly studied phosphorylation
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13.03.2025

On the Uniqueness of Kantorovich Potentials

Authors Staudt T, Hundrieser S, Munk A Journal SIAM Journal on Mathematics of Data Science Citation SIAM Journal on Mathematical Analysis 2025 57:2, 1452-1482. Abstract Kantorovich potentials denote the dual solutions of the renowned optimal transportation problem. Uniqueness of these solutions is relevant from both a theoretical and an algorithmic
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13.03.2025

Anle138b ameliorates pathological phenotypes in mouse and cellular models of Huntington’s disease

Authors da Silva Padilha M, Koyuncu S, Chabanis E, Ryazanov S, Leonov A, Vilchez S, Klein R, Giese A, Griesinger C, Dudanova I Journal BioRxiv Citation bioRxiv 2025.03.11.642540. Abstract Huntington′s disease (HD) is a debilitating hereditary movement disorder caused by a CAG repeat expansion in the huntingtin gene. HD is
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13.03.2025

A feedback circuitry involving γ-actin, β-actin and nonmuscle myosin-2 A controls tight junction and apical cortex mechanics

Authors Maupérin M, Sun Y, Glandorf T, Oswald TA, Klatt N, Geil B, Mutero-Maeda A, Méan I, Jond L, Janshoff A, Yan J, Citi S Journal Nature Communications Citation Nat Commun. 2025 Mar 13;16(1):2514. Abstract Cytoplasmic β- and γ-actin isoforms, along with non-muscle myosin 2 isoforms, are tightly regulated in
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Artistic depiction of the 3D structure of Nipah virus RNA polymerase in the active state. The structure of the Nipah virus RNA polymerase is shown as a transparent surface representation (L protein in green, P protein in orange). The viral RNA, which serves as a template for the RNA polymerase, is shown in blue, the newly produced product RNA in red. The nucleotide substrate is shown in yellow. © Fernanda Sala / UMG

10.03.2025

Molecular 3D structure of viral “copying machine” deciphered

Researchers at the University Medical Center Göttingen (UMG) and the Max Planck Institute (MPI) for Multidisciplinary Sciences have shown, for the first time, how the genetic material of the Nipah virus replicates in infected cells. The virus can cause fatal encephalitis in humans. Using cryo-electron microscopy, the team led by
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10.03.2025

Leaflet-specific Structure and Dynamics of Solid and Polymer Supported Lipid Bilayers

Authors Karedla N, Schneider F, Enderlein J, Chen T Journal Angewandte Chemie (International ed. in Engl.) Citation Angew Chem Int Ed Engl. 2025 Mar 10:e202423784. Abstract Polymer-supported or tethered lipid bilayers serve as versatile platforms for mimicking plasma membrane structure and dynamics, yet the impact of polymer supports on lipid
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07.03.2025

3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography

Authors Schaeper JJ, Kampshoff CA, Wolf BJ, Roos L, Michanski S, Ruhwedel T, Eckermann M, Meyer A, Jeschke M, Wichmann C, Moser T, Salditt T Journal Scientific Reports Citation Sci Rep. 2025 Mar 7;15(1):7933. Abstract Multi-scale X-ray phase contrast tomography (XPCT) enables three-dimensional (3D), non-destructive imaging of intact small animal
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