2025

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29.01.2025

Cortical population coding critically depends on fine-tuning of cell physiology

Authors Revah O, Wolf F, Gutnick MJ, Neef A Journal Biorxiv Citation bioRxiv 2024.02.15.580451. Abstract Cortical function reflects the activities of populations of neurons. How accurately they can encode information depends on the speed with which each neuron can respond to input, as revealed by dynamic gain analysis. Theory predicts
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The heart patch is produced from induced pluripotent stem cells derived heart muscle cells in a collagen hydrogel. Illustration: umg/eva meyer-besting

29.01.2025

Study results open door to heart failure treatment with ‘heart patch’

Results from rhesus macaques provide solid ground for a first-in-human investigation of heart repair with stem cell-derived engineered heart muscle. The study is a milestone for the clinical application of the ‘heart patch’ as an innovative treatment option for patients with advanced heart failure at the University Medical Center Göttingen
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The heart patch is produced from induced pluripotent stem cells derived heart muscle cells in a collagen hydrogel. Illustration: umg/eva meyer-besting

29.01.2025

Study results open door to heart failure treatment with ‘heart patch’

Results from rhesus macaques provide solid ground for a first-in-human investigation of heart repair with stem cell-derived engineered heart muscle. The study is a milestone for the clinical application of the ‘heart patch’ as an innovative treatment option for patients with advanced heart failure at the University Medical Center Göttingen
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28.01.2025

Computational functions of precisely balanced neuronal microcircuits in an olfactory memory network

Authors Meissner-Bernard C, Jenkins B, Rupprecht P, Bouldoires EA, Zenke F, Friedrich RW, Frank T Journal Cell Reports Citation Cell Reports 44, 115330, March 25, 2025. Abstract Models of balanced autoassociative memory networks predict that specific inhibition is critical to store information in connectivity. To explore these predictions, we characterized
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23.01.2025

Leonardo: A Toolset to Remove Sample-Induced Aberrations in Light Sheet Microscopy Images

Authors Liu Y, Müller G, Kowitz L, Chobola T, Weiss K, Maier P, Luo J, Roeßing M, Stenzel M, Grüneboom A, Paetzold J, Ertürk A, Navab N, Marr C, Chen J, Huisken J, Peng T Journal Research Square Citation Research Square 2025. Abstract Selective plane illumination microscopy (SPIM, also known
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22.01.2025

A Photoswitchable Tryptophan Zipper – (Un)folding Fibrils in Seconds

Authors Cotroneo ER, Cheng TC, Kaltschnee L, Maibach P, Engelke M, Schwegler N, Thomas F, Thiele CM, Simeth N Journal ChemRxiv Citation ChemRxiv. 2025. Abstract Peptides and proteins, that have the tendency to form aggregates, are often discussed in the context of Alz-heimer’s, Huntington’s, or Parkinson’s disease. However, studying aggregation
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22.01.2025

Structures of the 26S proteasome in complex with the Hsp70 cochaperone Bag1 reveal a novel mechanism of ubiquitin-independent proteasomal degradation

Authors Maestro-Lopez M, Cheng TC, Muntaner J, Menendez M, Alonso M, Schweitzer A, Cuellar J, Valpuesta JM, Sakata E Journal BioRxiv Citation bioRxiv 2025.01.22.633148. Abstract The 26S proteasome primarily degrades proteins marked by polyubiquitin chains. Although ubiquitin-independent pathways for proteasomal degradation exist, the mechanisms involved remain poorly understood. Bag1 links
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22.01.2025

Three-dimensional structure of entire hydrated murine hearts at histological resolution

Authors Frohn J, Böddeker F, Reichardt M, Bruns H, Czajka T, Khan A, Broche L, Krisch M, Bravin A, Alves F, Zschüntzsch J, Salditt T Journal Scientific Reports Citation Sci Rep. 2025 Jan 22;15(1):2766. Abstract Imaging the entire cardiomyocyte network in entire small animal hearts at single cell resolution is
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20.01.2025

Robust inference of cooperative behaviour of multiple ion channels in voltage-clamp recordings

Authors Requardt R, Fink M, Kubica P, Steinem C, Munk A, Li H   Journal IEEE Transactions on NanoBioScience (TNB)   Citation IEEE Transactions on NanoBioScience (TNB). 2025.   Abstract Recent experimental studies have shed light on the intriguing possibility that ion channels exhibit cooperative behaviour. However, a comprehensive understanding
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20.01.2025

MedicoSAM: Towards foundation models for medical image segmentation

Authors Archit A, Freckmann L, Pape C Journal Arxiv Citation arXiv:2501.11734. Abstract Medical image segmentation is an important analysis task in clinical practice and research. Deep learning has massively advanced the field, but current approaches are mostly based on models trained for a specific task. Training such models or adapting
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