2025

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The 3D model helps researchers to better understand the structure and function of the mechanical spring on the ion channel. From left to right: Prof. Martin Göpfert, Dr. Thomas Effertz, Dr. Philip Hehlert. (Photo: Philip Hehlert)

03.03.2025

Hearing triggered by molecular “spring”

Göttingen research team gains new insights into the sense of hearing   Hearing begins with the stretching of elastic molecular “springs” that open ion channels in the sensory hair cells of the ear. For decades, researchers have known that these gating springs must exist, but they could not find them.
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03.03.2025

Induced Pluripotent Stem Cell Lines as a Model for Studying the Cellular Phase of Parkinson’s Disease

Authors Abdelrasol H, Outeiro TF Journal Journal of the Society of Medical Sciences of Lisbon Citation JSCMed 2025;169(1). Abstract Parkinson’s disease (PD) is a complex neurodegenerative disorder, characterized by the progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNpc) as a result of intraneural deposition of aggregated alpha-synuclein
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28.02.2025

Optimizing Electrical Field Stimulation Parameters Reveals the Maximum Contractile Function of Human Skeletal Muscle Microtissues

Authors Tiper Y, Xie Z, Hofemeier AD, Lad H, Luber M, Krawetz R, Betz T, Zimmermann WH, Morton AB, Segal SS, Gilbert PM. Journal American Journal of Physiology. Cell Physiology Citation Am J Physiol Cell Physiol. 2025 Feb 28. Abstract Skeletal muscle microtissues are engineered to develop therapies for restoring
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27.02.2025

The keratin cortex stabilizes cells at high strains

Authors Meyer R, Rölleke U, Schwarz N, Perez-Tirado A, Schepers AV, Janshoff A, Köster S Journal BioRxiv Citation bioRxiv 2025.02.24.639846. Abstract The eukaryotic cytoskeleton consists of three filament types: actin filaments, microtubules and intermediate filaments (IFs). IF proteins are expressed in a cell-type specific manner, and keratins are found in
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26.02.2025

Inhibition of the Parkinson’s Disease-Related Protein DJ-1 by Endogenous Neurotoxins of the 1,2,3,4-Tetrahydroisoquinoline Family

Authors Laurent C, Poncet G, Herskovits T, Alves de Sousa R, Le Corre L, Al-Azzani M, Koenig A, Birman S, Outeiro TF, Mansuy D, Dairou J   Journal ACS Chemical Neuroscience   Citation ACS Chem Neurosci. 2025 Feb 26.   Abstract The protein DJ-1 appears to play a protective role
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25.02.2025

The plastid-encoded RNA polymerase of plant chloroplasts

Authors Ahrens FM, do Prado PFV, Hillen HS, Pfannschmidt T   Journal Trends in Plant Science   Citation Trends Plant Sci. 2025 Feb 25:S1360-1385(25)00031-7.   Abstract Plant chloroplasts possess a dedicated genome (plastome) and a prokaryotic-type plastid-encoded RNA polymerase (PEP) that mediates its expression. PEP is composed of five bacteria-like
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25.02.2025

Expanding our understanding of synucleinopathies: proteinopathy, proteinopenia, and lipidopathy

Authors Flores-León M, Outeiro TF   Journal FEBS Journal   Citation FEBS J. 2025 Feb 25.   Abstract A possible consequence of the process of protein aggregation in neurodegenerative diseases is the depletion of soluble protein species (proteinopenia), which may, at least in some cases, reduce protein function/activity. This concept,
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23.02.2025

Astroglial modulation of synaptic function in the non-demyelinated cerebellar cortex is dependent on MyD88 signaling in a model of toxic demyelination

Authors Lohrberg M, Mortensen LS, Thomas C, Fries F, van der Meer F, Götz A, Landt C, Rhee HJ, Rhee J, Gómez-Varela D, Schmidt M, Möbius W, Ruhwedel T, Pardo LA, Remling L, Kramann N, Wrzos C, Bahn E, Stadelmann C, Barrantes-Freer A Journal Journal of Neuroinflammation Citation J Neuroinflammation.
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Image showing plant cells acquired with a fluorescence microscope that were segmented automatically with the model. The underlying data is three-dimensional and the image shows a rendering of the segmented cells, each represented by a different colour. Photo: Nature Methods: s41592-021-01249-6

20.02.2025

Segment Anything for Microscopy

International research team led by Göttingen University develops user-friendly software method   Identifying and delineating cell structures in microscopy images is crucial for understanding the complex processes of life. This task is called “segmentation” and it enables a range of applications, such as analysing the reaction of cells to drug
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14.02.2025

Molecular Level Super-Resolution Fluorescence Imaging

Authors Radmacher N, Chizhik AI, Nevskyi O, Gallea JI, Gregor I, Enderlein J Journal Annual Review of Biophysics Citation Annu Rev Biophys. 2025 Feb 14. Abstract Over the last 30 years, fluorescence microscopy, renowned for its sensitivity and specificity, has undergone a revolution in resolving ever-smaller details. This advancement began
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