2023

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29.12.2023

Identification of TMEM126A as OXA1L-interacting protein reveals cotranslational quality control in mitochondria

Authors Poerschke S, Oeljeklaus S, Cruz-Zaragoza LD, Schenzielorz A, Dahal D, Hillen HS, Das H, Kremer LS, Valpadashi A, Breuer M, Sattmann J, Richter-Dennerlein R, Warscheid B, Dennerlein S, Rehling P Journal Molecular Cell Citation Mol Cell. 2023 Dec 29:S1097-2765(23)01031-6. Abstract Cellular proteostasis requires transport of polypeptides across membranes. Although
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28.12.2023

SparseProp: Efficient Event-Based Simulation and Training of Sparse Recurrent Spiking Neural Networks

Authors Engelken R Journal Arxiv Citation arXiv:2312.17216. Abstract Spiking Neural Networks (SNNs) are biologically-inspired models that are capable of processing information in streams of action potentials. However, simulating and training SNNs is computationally expensive due to the need to solve large systems of coupled differential equations. In this paper, we
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28.12.2023

Characteristics, Prevalence, and Clinical Relevance of Juxtacortical Paramagnetic Rims in Patients With Multiple Sclerosis

Authors Galbusera R, Bahn E, Weigel M, Cagol A, Lu PJ, Schaedelin SA, Franz J, Barakovic M, Rahmanzadeh R, Dechent P, Nair G, Brück W, Kuhle J, Kappos L, Stadelmann C, Granziera C Journal Neurology Citation Neurology. 2024 Feb 13;102(3):e207966. Abstract Background and Objectives: A subgroup of patients with multiple
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27.12.2023

Adaptive minimax optimality in statistical inverse problems via SOLIT — Sharp Optimal Lepskii-Inspired Tuning

Authors Li H, Werner F   Journal Inverse Problems   Citation Inverse Problems 40 (2024) 025005 (29pp).   Abstract We consider statistical linear inverse problems in separable Hilbert spaces and filter-based reconstruction methods of the form ^fα = qα (T∗T) T∗Y, where Y is the available data, T the forward
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27.12.2023

Structural and functional insights into tRNA recognition by human tRNA guanine transglycosylase

Authors Sievers K, Neumann P, Sušac L, Da Vela S, Graewert M, Trowitzsch S, Svergun D, Tampé R, Ficner R Journal Structure Citation Structure. 2023 Dec 27:S0969-2126(23)00447-1. Abstract Eukaryotic tRNA guanine transglycosylase (TGT) is an RNA-modifying enzyme which catalyzes the base exchange of the genetically encoded guanine 34 of tRNAsAsp,Asn,His,Tyr
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27.12.2023

Region-Specific Phosphorylation Determines Neuroligin-3 Localization to Excitatory Versus Inhibitory Synapses

Authors Altas B, Tuffy LP, Patrizi A, Dimova K, Soykan T, Brandenburg C, Romanowski AJ, Whitten JR, Robertson CD, Khim SN, Crutcher GW, Ambrozkiewicz MC, Yagensky O, Krueger-Burg D, Hammer M, Hsiao HH, Laskowski PR, Dyck L, Puche AC, Sassoè-Pognetto M, Chua JJE, Urlaub H, Jahn O, Brose N, Poulopoulos
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3D microscope image showing separation of actin isoforms in a cluster of cells. The uppermost layer (stained red) consists of gamma actin, whilst the base and edges display beta actin (green), which illustrates that gamma actin prefers to form rigid networks near the cell’s apex while beta actin preferentially forms parallel bundles with a distinct organizational pattern. Photo: Andreas Janshoff

21.12.2023

Big impacts from small changes in cell

Research at Göttingen and Warwick Universities reveals how filament interactions affect cellular networks   Tiny things matter – for instance, one amino acid can completely alter the architecture of the cell. Researchers at the Universities of Göttingen and Warwick investigated the structure and mechanics of the main component of the
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21.12.2023

Generation of a fluorescent oligodendrocyte reporter line in human induced pluripotent stem cells

Authors Schreiber MK, Zafeiriou MP Journal Stem Cell Research Citation Stem Cell Res, 21 December 2023, 103295. Abstract Human brain organoids can serve as models to study myelination, a process orchestrated by oligodendrocytes. Real-time imaging provides new insights on the communication of oligodendrocytes with neurons as well as demyelination processes
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21.12.2023

Visualization of deglutition and gastroesophageal reflux using real-time MRI: a standardized approach to image acquisition and assessment

Authors Biggemann L, Uhlig J, Streit U, Al-Bourini O, Wedi E, Amanzada A, Ellenrieder V, Rühlmann F, Ghadimi M, Frahm J, Uecker M, Seif Amir Hosseini A Journal Science Reports Citation Sci Rep. 2023 Dec 21;13(1):22854. Abstract This study aims to develop a standardized algorithm for gastroesophageal image acquisition and
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19.12.2023

GPATCH4 regulates rRNA and snRNA 2′-O-methylation in both DHX15-dependent and DHX15-independent manners

Authors Kanwal N, Krogh N, Memet I, Lemus-Diaz N, Thomé CC, Welp LM, Mizi A, Hackert P, Papantonis A, Urlaub H, Nielsen H, Bohnsack KE, Bohnsack MT Journal Nucleic Acids Research Citation Nucleic Acids Res. 2023 Dec 19:gkad1202. Abstract Regulation of RNA helicase activity, often accomplished by protein cofactors, is
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